Prevalence, distribution and clinical correlates of myocardial fibrosis in systemic lupus erythematosus: A cardiac magnetic resonance study

Martin G. Seneviratne, S. M. Grieve, G. A. Figtree, R. Garsia, D. S. Celermajer, S. Adelstein, Rajesh Puranik

Research output: Contribution to journalArticle

Abstract

Objectives: To assess the prevalence, distribution and clinical correlates of myocardial fibrosis, as detected by cardiac magnetic resonance (CMR), in systemic lupus erythematosus (SLE). 

Methods: Forty-one subjects (average age 39 ± 12 years and 80% female) with SLE underwent CMR imaging at 1.5T, using late gadolinium enhancement (LGE) to quantify the area of myocardial fibrosis in the left ventricle (LV). Subjects also underwent transthoracic echocardiography (TTE) and exercise testing. 

Results: LGE was detected in 15/41 subjects, 11 with localized LGE (<15% LV mass) and four with extensive LGE (>15% LV mass). The commonest site of LGE was the interventricular septum, with all but one case demonstrating an intramural or inflammatory pattern. The mean age of the >15% LGE group (55 ± 15 years) was significantly higher than the <15% or absent LGE subgroups. Based on both CMR and TTE measurements, subjects with LGE > 15% demonstrated a reduced E/A ratio of 0.9 ± 0.4 relative to the <15% and absent LGE subgroups. LV end-systolic volume (ESVi), end-diastolic volume (EDVi) and maximum exercise capacity were also reduced in the >15% LGE group. 

Conclusions: Mid-wall myocardial fibrosis occurs frequently in SLE and is strongly associated with advancing subject age, but not with SLE duration or severity. Extensive LGE may be associated with diastolic dysfunction and impaired exercise capacity, although this may be an epiphenomenon of age. Cardiac magnetic resonance with quantitative assessment of LGE may provide a basis for cardiac risk stratification in SLE.

Original languageEnglish
Pages (from-to)573-581
Number of pages9
JournalLupus
Volume25
Issue number6
DOIs
Publication statusPublished - 2016
Externally publishedYes

    Fingerprint

Cite this

Seneviratne, M. G., Grieve, S. M., Figtree, G. A., Garsia, R., Celermajer, D. S., Adelstein, S., & Puranik, R. (2016). Prevalence, distribution and clinical correlates of myocardial fibrosis in systemic lupus erythematosus: A cardiac magnetic resonance study. Lupus, 25(6), 573-581. https://doi.org/10.1177/0961203315622275