Prognostic utility of estimated albumin excretion rate in chronic kidney disease

results from the Study of Heart and Renal Protection

Marion M Mafham, Natalie D Staplin, Jonathan R Emberson, Richard Haynes, William Herrington, Christina Reith, Christoph Wanner, Robert Walker, Alan Cass, Adeera Levin, Bengt Fellstrom, Lixin Jiang, Hallvard Holdaas, Bertram Kasiske, David C. Wheeler, Martin J. Landray, Colin Baigent

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Abstract

BACKGROUND: Estimated albumin excretion rate (eAER) provides a better estimate of 24-h albuminuria than albumin:creatinine ratio (ACR). However, whether eAER is superior to ACR in predicting end-stage renal disease (ESRD), vascular events (VEs) or death is uncertain.

METHODS: The prognostic utility of ACR and eAER (estimated from ACR, sex, age and race) to predict mortality, ESRD and VEs was compared using Cox proportional hazards regression among 5552 participants with chronic kidney disease in the Study of Heart and Renal Protection, who were not on dialysis at baseline.

RESULTS: During a median follow-up of 4.8 years, 1959 participants developed ESRD, 1204 had a VE and 1130 died (641 from a non-vascular, 369 from a vascular and 120 from an unknown cause). After adjustment for age, sex and eGFR, both ACR and eAER were strongly and similarly associated with ESRD risk. The average relative risk (RR) per 10-fold higher level was 2.70 (95% confidence interval 2.45-2.98) for ACR and 2.67 (2.43-2.94) for eAER. Neither ACR nor eAER provided any additional prognostic information for ESRD risk over and above the other. For VEs, there were modest positive associations between both ACR and eAER and risk [adjusted RR per 10-fold higher level 1.37 (1.22-1.53) for ACR and 1.36 (1.22-1.52) for eAER]. Again, neither measure added prognostic information over and above the other. Similar results were observed when ACR and eAER were related to vascular mortality [RR per 10-fold higher level: 1.64 (1.33-2.03) and 1.62 (1.32-2.00), respectively] or to non-vascular mortality [1.53 (1.31-1.79) and 1.50 (1.29-1.76), respectively].

CONCLUSIONS: In this study, eAER did not improve risk prediction of ESRD, VEs or mortality.
Original languageEnglish
Pages (from-to)257-264
Number of pages8
JournalNephrology Dialysis Transplantation
Volume33
Issue number2
Early online date14 Jan 2017
DOIs
Publication statusPublished - 1 Feb 2018

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Chronic Renal Insufficiency
Albumins
Kidney
Creatinine
Blood Vessels
Chronic Kidney Failure
Mortality
Albuminuria
Sex Ratio

Cite this

Mafham, Marion M ; Staplin, Natalie D ; Emberson, Jonathan R ; Haynes, Richard ; Herrington, William ; Reith, Christina ; Wanner, Christoph ; Walker, Robert ; Cass, Alan ; Levin, Adeera ; Fellstrom, Bengt ; Jiang, Lixin ; Holdaas, Hallvard ; Kasiske, Bertram ; Wheeler, David C. ; Landray, Martin J. ; Baigent, Colin. / Prognostic utility of estimated albumin excretion rate in chronic kidney disease : results from the Study of Heart and Renal Protection. In: Nephrology Dialysis Transplantation. 2018 ; Vol. 33, No. 2. pp. 257-264.
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title = "Prognostic utility of estimated albumin excretion rate in chronic kidney disease: results from the Study of Heart and Renal Protection",
abstract = "BACKGROUND: Estimated albumin excretion rate (eAER) provides a better estimate of 24-h albuminuria than albumin:creatinine ratio (ACR). However, whether eAER is superior to ACR in predicting end-stage renal disease (ESRD), vascular events (VEs) or death is uncertain.METHODS: The prognostic utility of ACR and eAER (estimated from ACR, sex, age and race) to predict mortality, ESRD and VEs was compared using Cox proportional hazards regression among 5552 participants with chronic kidney disease in the Study of Heart and Renal Protection, who were not on dialysis at baseline.RESULTS: During a median follow-up of 4.8 years, 1959 participants developed ESRD, 1204 had a VE and 1130 died (641 from a non-vascular, 369 from a vascular and 120 from an unknown cause). After adjustment for age, sex and eGFR, both ACR and eAER were strongly and similarly associated with ESRD risk. The average relative risk (RR) per 10-fold higher level was 2.70 (95{\%} confidence interval 2.45-2.98) for ACR and 2.67 (2.43-2.94) for eAER. Neither ACR nor eAER provided any additional prognostic information for ESRD risk over and above the other. For VEs, there were modest positive associations between both ACR and eAER and risk [adjusted RR per 10-fold higher level 1.37 (1.22-1.53) for ACR and 1.36 (1.22-1.52) for eAER]. Again, neither measure added prognostic information over and above the other. Similar results were observed when ACR and eAER were related to vascular mortality [RR per 10-fold higher level: 1.64 (1.33-2.03) and 1.62 (1.32-2.00), respectively] or to non-vascular mortality [1.53 (1.31-1.79) and 1.50 (1.29-1.76), respectively].CONCLUSIONS: In this study, eAER did not improve risk prediction of ESRD, VEs or mortality.",
author = "Mafham, {Marion M} and Staplin, {Natalie D} and Emberson, {Jonathan R} and Richard Haynes and William Herrington and Christina Reith and Christoph Wanner and Robert Walker and Alan Cass and Adeera Levin and Bengt Fellstrom and Lixin Jiang and Hallvard Holdaas and Bertram Kasiske and Wheeler, {David C.} and Landray, {Martin J.} and Colin Baigent",
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pages = "257--264",
journal = "Nephrology Dialysis Transplantation",
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Mafham, MM, Staplin, ND, Emberson, JR, Haynes, R, Herrington, W, Reith, C, Wanner, C, Walker, R, Cass, A, Levin, A, Fellstrom, B, Jiang, L, Holdaas, H, Kasiske, B, Wheeler, DC, Landray, MJ & Baigent, C 2018, 'Prognostic utility of estimated albumin excretion rate in chronic kidney disease: results from the Study of Heart and Renal Protection', Nephrology Dialysis Transplantation, vol. 33, no. 2, pp. 257-264. https://doi.org/10.1093/ndt/gfw396

Prognostic utility of estimated albumin excretion rate in chronic kidney disease : results from the Study of Heart and Renal Protection. / Mafham, Marion M ; Staplin, Natalie D; Emberson, Jonathan R ; Haynes, Richard; Herrington, William; Reith, Christina; Wanner, Christoph; Walker, Robert; Cass, Alan; Levin, Adeera; Fellstrom, Bengt ; Jiang, Lixin; Holdaas, Hallvard; Kasiske, Bertram; Wheeler, David C.; Landray, Martin J. ; Baigent, Colin.

In: Nephrology Dialysis Transplantation, Vol. 33, No. 2, 01.02.2018, p. 257-264.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Prognostic utility of estimated albumin excretion rate in chronic kidney disease

T2 - results from the Study of Heart and Renal Protection

AU - Mafham, Marion M

AU - Staplin, Natalie D

AU - Emberson, Jonathan R

AU - Haynes, Richard

AU - Herrington, William

AU - Reith, Christina

AU - Wanner, Christoph

AU - Walker, Robert

AU - Cass, Alan

AU - Levin, Adeera

AU - Fellstrom, Bengt

AU - Jiang, Lixin

AU - Holdaas, Hallvard

AU - Kasiske, Bertram

AU - Wheeler, David C.

AU - Landray, Martin J.

AU - Baigent, Colin

PY - 2018/2/1

Y1 - 2018/2/1

N2 - BACKGROUND: Estimated albumin excretion rate (eAER) provides a better estimate of 24-h albuminuria than albumin:creatinine ratio (ACR). However, whether eAER is superior to ACR in predicting end-stage renal disease (ESRD), vascular events (VEs) or death is uncertain.METHODS: The prognostic utility of ACR and eAER (estimated from ACR, sex, age and race) to predict mortality, ESRD and VEs was compared using Cox proportional hazards regression among 5552 participants with chronic kidney disease in the Study of Heart and Renal Protection, who were not on dialysis at baseline.RESULTS: During a median follow-up of 4.8 years, 1959 participants developed ESRD, 1204 had a VE and 1130 died (641 from a non-vascular, 369 from a vascular and 120 from an unknown cause). After adjustment for age, sex and eGFR, both ACR and eAER were strongly and similarly associated with ESRD risk. The average relative risk (RR) per 10-fold higher level was 2.70 (95% confidence interval 2.45-2.98) for ACR and 2.67 (2.43-2.94) for eAER. Neither ACR nor eAER provided any additional prognostic information for ESRD risk over and above the other. For VEs, there were modest positive associations between both ACR and eAER and risk [adjusted RR per 10-fold higher level 1.37 (1.22-1.53) for ACR and 1.36 (1.22-1.52) for eAER]. Again, neither measure added prognostic information over and above the other. Similar results were observed when ACR and eAER were related to vascular mortality [RR per 10-fold higher level: 1.64 (1.33-2.03) and 1.62 (1.32-2.00), respectively] or to non-vascular mortality [1.53 (1.31-1.79) and 1.50 (1.29-1.76), respectively].CONCLUSIONS: In this study, eAER did not improve risk prediction of ESRD, VEs or mortality.

AB - BACKGROUND: Estimated albumin excretion rate (eAER) provides a better estimate of 24-h albuminuria than albumin:creatinine ratio (ACR). However, whether eAER is superior to ACR in predicting end-stage renal disease (ESRD), vascular events (VEs) or death is uncertain.METHODS: The prognostic utility of ACR and eAER (estimated from ACR, sex, age and race) to predict mortality, ESRD and VEs was compared using Cox proportional hazards regression among 5552 participants with chronic kidney disease in the Study of Heart and Renal Protection, who were not on dialysis at baseline.RESULTS: During a median follow-up of 4.8 years, 1959 participants developed ESRD, 1204 had a VE and 1130 died (641 from a non-vascular, 369 from a vascular and 120 from an unknown cause). After adjustment for age, sex and eGFR, both ACR and eAER were strongly and similarly associated with ESRD risk. The average relative risk (RR) per 10-fold higher level was 2.70 (95% confidence interval 2.45-2.98) for ACR and 2.67 (2.43-2.94) for eAER. Neither ACR nor eAER provided any additional prognostic information for ESRD risk over and above the other. For VEs, there were modest positive associations between both ACR and eAER and risk [adjusted RR per 10-fold higher level 1.37 (1.22-1.53) for ACR and 1.36 (1.22-1.52) for eAER]. Again, neither measure added prognostic information over and above the other. Similar results were observed when ACR and eAER were related to vascular mortality [RR per 10-fold higher level: 1.64 (1.33-2.03) and 1.62 (1.32-2.00), respectively] or to non-vascular mortality [1.53 (1.31-1.79) and 1.50 (1.29-1.76), respectively].CONCLUSIONS: In this study, eAER did not improve risk prediction of ESRD, VEs or mortality.

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U2 - 10.1093/ndt/gfw396

DO - 10.1093/ndt/gfw396

M3 - Article

VL - 33

SP - 257

EP - 264

JO - Nephrology Dialysis Transplantation

JF - Nephrology Dialysis Transplantation

SN - 0931-0509

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