Proposed empiric antibiotic therapy for prosthetic joint infections: an analysis of the Prosthetic Joint Infection in Australia and New Zealand, Observational (PIANO) cohort

Joshua S. Davis, Sarah Metcalf, David L. Paterson, James O. Robinson, Benjamin Clarke, Laurens Manning

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Empiric antibiotic therapy in suspected prosthetic joint infection should cover likely pathogens while avoiding overly broad-spectrum antibiotics. We analysed individual patient data from a large prospective cohort study (Prosthetic Joint Infection in Australia and New Zealand, Observational (PIANO)) and found that causative organisms vary with the presentation type, with early post-operative infections more likely to be polymicrobial (41%) compared with late acute infections (10%). We thus propose empirical regimens tailored to the presentation type and presence or absence of sepsis.

    Original languageEnglish
    Pages (from-to)322-325
    Number of pages4
    JournalInternal Medicine Journal
    Volume52
    Issue number2
    DOIs
    Publication statusPublished - Feb 2022

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