Proposed empiric antibiotic therapy for prosthetic joint infections: An analysis of the Prosthetic Joint Infection in Australia and New Zealand, Observational (PIANO) cohort

Joshua S. Davis; Sarah Metcalf; David L. Paterson; James O. Robinson; Benjamin Clarke; Laurens Manning

doi:10.1111/imj.15677

Proposed empiric antibiotic therapy for prosthetic joint infections: An analysis of the Prosthetic Joint Infection in Australia and New Zealand, Observational (PIANO) cohort

Joshua S. Davis, Sarah Metcalf, David L. Paterson, James O. Robinson, Benjamin Clarke, Laurens Manning

Global and Tropical Health

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Empiric antibiotic therapy in suspected prosthetic joint infection should cover likely pathogens while avoiding overly broad-spectrum antibiotics. We analysed individual patient data from a large prospective cohort study (Prosthetic Joint Infection in Australia and New Zealand, Observational (PIANO)) and found that causative organisms vary with the presentation type, with early post-operative infections more likely to be polymicrobial (41%) compared with late acute infections (10%). We thus propose empirical regimens tailored to the presentation type and presence or absence of sepsis.

Original language	English
Pages (from-to)	322-325
Number of pages	4
Journal	Internal Medicine Journal
Volume	52
Issue number	2
DOIs	https://doi.org/10.1111/imj.15677
Publication status	Published - Feb 2022

Bibliographical note

Funding Information:
The original PIANO paper on which this paper was based received an educational grant from Heraeus Medical and the John Hunter Hospital Charitable Trust Fund.

Publisher Copyright:
© 2022 Royal Australasian College of Physicians.

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10.1111/imj.15677

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abstract = "Empiric antibiotic therapy in suspected prosthetic joint infection should cover likely pathogens while avoiding overly broad-spectrum antibiotics. We analysed individual patient data from a large prospective cohort study (Prosthetic Joint Infection in Australia and New Zealand, Observational (PIANO)) and found that causative organisms vary with the presentation type, with early post-operative infections more likely to be polymicrobial (41%) compared with late acute infections (10%). We thus propose empirical regimens tailored to the presentation type and presence or absence of sepsis.",

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Proposed empiric antibiotic therapy for prosthetic joint infections: An analysis of the Prosthetic Joint Infection in Australia and New Zealand, Observational (PIANO) cohort. / Davis, Joshua S.; Metcalf, Sarah; Paterson, David L. et al.
In: Internal Medicine Journal, Vol. 52, No. 2, 02.2022, p. 322-325.

Research output: Contribution to journal › Article › peer-review

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Proposed empiric antibiotic therapy for prosthetic joint infections: An analysis of the Prosthetic Joint Infection in Australia and New Zealand, Observational (PIANO) cohort

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