Prospective surveillance of invasive group A streptococcal disease, fiji, 2005-2007

Andrew Steer, A JENNEY, Joseph Kado, M GOOD, M BATZLOFF, L WAQATAKIREWA, Edward (Kim) MULHOLLAND, Jonathan Carapetis

    Research output: Contribution to journalArticlepeer-review


    We undertook a prospective active surveillance study of invasive group A streptococcal (GAS) disease in Fiji over a 23-month period, 2005-2007. We identified 64 cases of invasive GAS disease, which represents an average annualized all-ages incidence of 9.9 cases/100,000 population per year (95% confidence interval [CI] 7.6-12.6). Rates were highest in those >65 years of age and in those <5 years, particularly in infants, for whom the incidence was 44.9/100,000 (95% CI 18.1-92.5). The case-fatality rate was 32% and was associated with increasing age and underlying coexisting disease, including diabetes and renal disease. Fifty-five of the GAS isolates underwent emm sequence typing; the types were highly diverse, with 38 different emm subtypes and no particular dominant type. Our data support the view that invasive GAS disease is common in developing countries and deserves increased public health attention.
    Original languageEnglish
    Pages (from-to)216-222
    Number of pages7
    JournalEmerging Infectious Diseases
    Issue number2
    Publication statusPublished - 2009


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