Quantifying primaquine effectiveness and improving adherence

A round table discussion of the APMEN Vivax Working Group

Kamala Thriemer, Albino Bobogare, Benedikt Ley, Clarice Samo Gudo, Mohammad Shafiul Alam, Nick M. Anstey, Elizabeth Ashley, J. Kevin Baird, Charlotte Gryseels, Elodie Jambert, Marcus Lacerda, Ferdinand Laihad, Jutta Marfurt, Ayodhia Pitaloka Pasaribu, Jeanne Rini Poespoprodjo, Inge Sutanto, Walter R. Taylor, Christel Van Den Boogaard, Katherine E. Battle, Lek Dysoley & 78 others Prakash Ghimire, Bill Hawley, Jimee Hwang, Wasif Ali Khan, Rose Nani Binti Mudin, Maria Endang Sumiwi, Rukhsana Ahmed, M. M. Aktaruzzaman, Kiran Raj Awasthi, Azucena Bardaji, David Bell, Leonard Boaz, Faustina Helen Burdam, Daniel Chandramohan, Qin Cheng, Keobouphaphone Chindawongsa, Janice Culpepper, Santasabuj Das, Raffy Deray, Meghna Desai, Gonzalo Domingo, Wang Duoquan, Stephan Duparc, Rustini Floranita, Emily Gerth-Guyette, Rosalind E. Howes, Cecilia Hugo, George Jagoe, Elvieda Sariwati, Sanya Tahmina Jhora, Wu Jinwei, Harin Karunajeewa, Enny Kenangalem, Bibek Kumar Lal, Chandra Landuwulang, Emmanuel Le Perru, Sang Eun Lee, Leo Sora Makita, James McCarthy, Asrat Mekuria, Neelima Mishra, Esau Naket, Simone Nambanya, Johnny Nausien, Thang Ngo Duc, Thuan Nguyen Thi, Rinitis Noviyanti, Daniel Pfeffer, Gao Qi, Annisa Rahmalia, Stephen Rogerson, Iriani Samad, Jetsumon Sattabongkot, Ari Satyagraha, Dennis Shanks, Surender Nath Sharma, Carol Hopkins Sibley, Ali Sungkar, Din Syafruddin, Arunansu Talukdar, Joel Tarning, Feiko Ter Kuile, Suman Thapa, Minerva Theodora, Tho Tran Huy, Edward Waramin, Govert Waramori, Adugna Woyessa, Chansuda Wongsrichanalai, Nguyen Xuan Xa, Joon Sup Yeom, Lukas Hermawan, Angela Devine, Spike Nowak, Indra Jaya, Supargiyono Supargiyono, Koen Peeters Grietens, Ric N. Price

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    Abstract

    The goal to eliminate malaria from the Asia-Pacific by 2030 will require the safe and widespread delivery of effective radical cure of malaria. In October 2017, the Asia Pacific Malaria Elimination Network Vivax Working Group met to discuss the impediments to primaquine (PQ) radical cure, how these can be overcome and the methodological difficulties in assessing clinical effectiveness of radical cure. The salient discussions of this meeting which involved 110 representatives from 18 partner countries and 21 institutional partner organizations are reported. Context specific strategies to improve adherence are needed to increase understanding and awareness of PQ within affected communities; these must include education and health promotion programs. Lessons learned from other disease programs highlight that a package of approaches has the greatest potential to change patient and prescriber habits, however optimizing the components of this approach and quantifying their effectiveness is challenging. In a trial setting, the reactivity of participants results in patients altering their behaviour and creates inherent bias. Although bias can be reduced by integrating data collection into the routine health care and surveillance systems, this comes at a cost of decreasing the detection of clinical outcomes. Measuring adherence and the factors that relate to it, also requires an in-depth understanding of the context and the underlying sociocultural logic that supports it. Reaching the elimination goal will require innovative approaches to improve radical cure for vivax malaria, as well as the methods to evaluate its effectiveness.

    Original languageEnglish
    Article number241
    Pages (from-to)1-7
    Number of pages7
    JournalMalaria Journal
    Volume17
    DOIs
    Publication statusPublished - 20 Jun 2018

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    Primaquine
    Malaria
    Vivax Malaria
    Health Promotion
    Habits
    Organizations
    Delivery of Health Care
    Education
    Costs and Cost Analysis

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    Thriemer, Kamala ; Bobogare, Albino ; Ley, Benedikt ; Gudo, Clarice Samo ; Alam, Mohammad Shafiul ; Anstey, Nick M. ; Ashley, Elizabeth ; Baird, J. Kevin ; Gryseels, Charlotte ; Jambert, Elodie ; Lacerda, Marcus ; Laihad, Ferdinand ; Marfurt, Jutta ; Pasaribu, Ayodhia Pitaloka ; Poespoprodjo, Jeanne Rini ; Sutanto, Inge ; Taylor, Walter R. ; Van Den Boogaard, Christel ; Battle, Katherine E. ; Dysoley, Lek ; Ghimire, Prakash ; Hawley, Bill ; Hwang, Jimee ; Khan, Wasif Ali ; Mudin, Rose Nani Binti ; Sumiwi, Maria Endang ; Ahmed, Rukhsana ; Aktaruzzaman, M. M. ; Awasthi, Kiran Raj ; Bardaji, Azucena ; Bell, David ; Boaz, Leonard ; Burdam, Faustina Helen ; Chandramohan, Daniel ; Cheng, Qin ; Chindawongsa, Keobouphaphone ; Culpepper, Janice ; Das, Santasabuj ; Deray, Raffy ; Desai, Meghna ; Domingo, Gonzalo ; Duoquan, Wang ; Duparc, Stephan ; Floranita, Rustini ; Gerth-Guyette, Emily ; Howes, Rosalind E. ; Hugo, Cecilia ; Jagoe, George ; Sariwati, Elvieda ; Jhora, Sanya Tahmina ; Jinwei, Wu ; Karunajeewa, Harin ; Kenangalem, Enny ; Lal, Bibek Kumar ; Landuwulang, Chandra ; Le Perru, Emmanuel ; Lee, Sang Eun ; Makita, Leo Sora ; McCarthy, James ; Mekuria, Asrat ; Mishra, Neelima ; Naket, Esau ; Nambanya, Simone ; Nausien, Johnny ; Duc, Thang Ngo ; Thi, Thuan Nguyen ; Noviyanti, Rinitis ; Pfeffer, Daniel ; Qi, Gao ; Rahmalia, Annisa ; Rogerson, Stephen ; Samad, Iriani ; Sattabongkot, Jetsumon ; Satyagraha, Ari ; Shanks, Dennis ; Sharma, Surender Nath ; Sibley, Carol Hopkins ; Sungkar, Ali ; Syafruddin, Din ; Talukdar, Arunansu ; Tarning, Joel ; Ter Kuile, Feiko ; Thapa, Suman ; Theodora, Minerva ; Huy, Tho Tran ; Waramin, Edward ; Waramori, Govert ; Woyessa, Adugna ; Wongsrichanalai, Chansuda ; Xa, Nguyen Xuan ; Yeom, Joon Sup ; Hermawan, Lukas ; Devine, Angela ; Nowak, Spike ; Jaya, Indra ; Supargiyono, Supargiyono ; Grietens, Koen Peeters ; Price, Ric N. / Quantifying primaquine effectiveness and improving adherence : A round table discussion of the APMEN Vivax Working Group. In: Malaria Journal. 2018 ; Vol. 17. pp. 1-7.
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    abstract = "The goal to eliminate malaria from the Asia-Pacific by 2030 will require the safe and widespread delivery of effective radical cure of malaria. In October 2017, the Asia Pacific Malaria Elimination Network Vivax Working Group met to discuss the impediments to primaquine (PQ) radical cure, how these can be overcome and the methodological difficulties in assessing clinical effectiveness of radical cure. The salient discussions of this meeting which involved 110 representatives from 18 partner countries and 21 institutional partner organizations are reported. Context specific strategies to improve adherence are needed to increase understanding and awareness of PQ within affected communities; these must include education and health promotion programs. Lessons learned from other disease programs highlight that a package of approaches has the greatest potential to change patient and prescriber habits, however optimizing the components of this approach and quantifying their effectiveness is challenging. In a trial setting, the reactivity of participants results in patients altering their behaviour and creates inherent bias. Although bias can be reduced by integrating data collection into the routine health care and surveillance systems, this comes at a cost of decreasing the detection of clinical outcomes. Measuring adherence and the factors that relate to it, also requires an in-depth understanding of the context and the underlying sociocultural logic that supports it. Reaching the elimination goal will require innovative approaches to improve radical cure for vivax malaria, as well as the methods to evaluate its effectiveness.",
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    author = "Kamala Thriemer and Albino Bobogare and Benedikt Ley and Gudo, {Clarice Samo} and Alam, {Mohammad Shafiul} and Anstey, {Nick M.} and Elizabeth Ashley and Baird, {J. Kevin} and Charlotte Gryseels and Elodie Jambert and Marcus Lacerda and Ferdinand Laihad and Jutta Marfurt and Pasaribu, {Ayodhia Pitaloka} and Poespoprodjo, {Jeanne Rini} and Inge Sutanto and Taylor, {Walter R.} and {Van Den Boogaard}, Christel and Battle, {Katherine E.} and Lek Dysoley and Prakash Ghimire and Bill Hawley and Jimee Hwang and Khan, {Wasif Ali} and Mudin, {Rose Nani Binti} and Sumiwi, {Maria Endang} and Rukhsana Ahmed and Aktaruzzaman, {M. M.} and Awasthi, {Kiran Raj} and Azucena Bardaji and David Bell and Leonard Boaz and Burdam, {Faustina Helen} and Daniel Chandramohan and Qin Cheng and Keobouphaphone Chindawongsa and Janice Culpepper and Santasabuj Das and Raffy Deray and Meghna Desai and Gonzalo Domingo and Wang Duoquan and Stephan Duparc and Rustini Floranita and Emily Gerth-Guyette and Howes, {Rosalind E.} and Cecilia Hugo and George Jagoe and Elvieda Sariwati and Jhora, {Sanya Tahmina} and Wu Jinwei and Harin Karunajeewa and Enny Kenangalem and Lal, {Bibek Kumar} and Chandra Landuwulang and {Le Perru}, Emmanuel and Lee, {Sang Eun} and Makita, {Leo Sora} and James McCarthy and Asrat Mekuria and Neelima Mishra and Esau Naket and Simone Nambanya and Johnny Nausien and Duc, {Thang Ngo} and Thi, {Thuan Nguyen} and Rinitis Noviyanti and Daniel Pfeffer and Gao Qi and Annisa Rahmalia and Stephen Rogerson and Iriani Samad and Jetsumon Sattabongkot and Ari Satyagraha and Dennis Shanks and Sharma, {Surender Nath} and Sibley, {Carol Hopkins} and Ali Sungkar and Din Syafruddin and Arunansu Talukdar and Joel Tarning and {Ter Kuile}, Feiko and Suman Thapa and Minerva Theodora and Huy, {Tho Tran} and Edward Waramin and Govert Waramori and Adugna Woyessa and Chansuda Wongsrichanalai and Xa, {Nguyen Xuan} and Yeom, {Joon Sup} and Lukas Hermawan and Angela Devine and Spike Nowak and Indra Jaya and Supargiyono Supargiyono and Grietens, {Koen Peeters} and Price, {Ric N.}",
    year = "2018",
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    doi = "10.1186/s12936-018-2380-8",
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    pages = "1--7",
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    Thriemer, K, Bobogare, A, Ley, B, Gudo, CS, Alam, MS, Anstey, NM, Ashley, E, Baird, JK, Gryseels, C, Jambert, E, Lacerda, M, Laihad, F, Marfurt, J, Pasaribu, AP, Poespoprodjo, JR, Sutanto, I, Taylor, WR, Van Den Boogaard, C, Battle, KE, Dysoley, L, Ghimire, P, Hawley, B, Hwang, J, Khan, WA, Mudin, RNB, Sumiwi, ME, Ahmed, R, Aktaruzzaman, MM, Awasthi, KR, Bardaji, A, Bell, D, Boaz, L, Burdam, FH, Chandramohan, D, Cheng, Q, Chindawongsa, K, Culpepper, J, Das, S, Deray, R, Desai, M, Domingo, G, Duoquan, W, Duparc, S, Floranita, R, Gerth-Guyette, E, Howes, RE, Hugo, C, Jagoe, G, Sariwati, E, Jhora, ST, Jinwei, W, Karunajeewa, H, Kenangalem, E, Lal, BK, Landuwulang, C, Le Perru, E, Lee, SE, Makita, LS, McCarthy, J, Mekuria, A, Mishra, N, Naket, E, Nambanya, S, Nausien, J, Duc, TN, Thi, TN, Noviyanti, R, Pfeffer, D, Qi, G, Rahmalia, A, Rogerson, S, Samad, I, Sattabongkot, J, Satyagraha, A, Shanks, D, Sharma, SN, Sibley, CH, Sungkar, A, Syafruddin, D, Talukdar, A, Tarning, J, Ter Kuile, F, Thapa, S, Theodora, M, Huy, TT, Waramin, E, Waramori, G, Woyessa, A, Wongsrichanalai, C, Xa, NX, Yeom, JS, Hermawan, L, Devine, A, Nowak, S, Jaya, I, Supargiyono, S, Grietens, KP & Price, RN 2018, 'Quantifying primaquine effectiveness and improving adherence: A round table discussion of the APMEN Vivax Working Group', Malaria Journal, vol. 17, 241, pp. 1-7. https://doi.org/10.1186/s12936-018-2380-8

    Quantifying primaquine effectiveness and improving adherence : A round table discussion of the APMEN Vivax Working Group. / Thriemer, Kamala; Bobogare, Albino; Ley, Benedikt; Gudo, Clarice Samo; Alam, Mohammad Shafiul; Anstey, Nick M.; Ashley, Elizabeth; Baird, J. Kevin; Gryseels, Charlotte; Jambert, Elodie; Lacerda, Marcus; Laihad, Ferdinand; Marfurt, Jutta; Pasaribu, Ayodhia Pitaloka; Poespoprodjo, Jeanne Rini; Sutanto, Inge; Taylor, Walter R.; Van Den Boogaard, Christel; Battle, Katherine E.; Dysoley, Lek; Ghimire, Prakash; Hawley, Bill; Hwang, Jimee; Khan, Wasif Ali; Mudin, Rose Nani Binti; Sumiwi, Maria Endang; Ahmed, Rukhsana; Aktaruzzaman, M. M.; Awasthi, Kiran Raj; Bardaji, Azucena; Bell, David; Boaz, Leonard; Burdam, Faustina Helen; Chandramohan, Daniel; Cheng, Qin; Chindawongsa, Keobouphaphone; Culpepper, Janice; Das, Santasabuj; Deray, Raffy; Desai, Meghna; Domingo, Gonzalo; Duoquan, Wang; Duparc, Stephan; Floranita, Rustini; Gerth-Guyette, Emily; Howes, Rosalind E.; Hugo, Cecilia; Jagoe, George; Sariwati, Elvieda; Jhora, Sanya Tahmina; Jinwei, Wu; Karunajeewa, Harin; Kenangalem, Enny; Lal, Bibek Kumar; Landuwulang, Chandra; Le Perru, Emmanuel; Lee, Sang Eun; Makita, Leo Sora; McCarthy, James; Mekuria, Asrat; Mishra, Neelima; Naket, Esau; Nambanya, Simone; Nausien, Johnny; Duc, Thang Ngo; Thi, Thuan Nguyen; Noviyanti, Rinitis; Pfeffer, Daniel; Qi, Gao; Rahmalia, Annisa; Rogerson, Stephen; Samad, Iriani; Sattabongkot, Jetsumon; Satyagraha, Ari; Shanks, Dennis; Sharma, Surender Nath; Sibley, Carol Hopkins; Sungkar, Ali; Syafruddin, Din; Talukdar, Arunansu; Tarning, Joel; Ter Kuile, Feiko; Thapa, Suman; Theodora, Minerva; Huy, Tho Tran; Waramin, Edward; Waramori, Govert; Woyessa, Adugna; Wongsrichanalai, Chansuda; Xa, Nguyen Xuan; Yeom, Joon Sup; Hermawan, Lukas; Devine, Angela; Nowak, Spike; Jaya, Indra; Supargiyono, Supargiyono; Grietens, Koen Peeters; Price, Ric N.

    In: Malaria Journal, Vol. 17, 241, 20.06.2018, p. 1-7.

    Research output: Contribution to journalMeeting AbstractResearchpeer-review

    TY - JOUR

    T1 - Quantifying primaquine effectiveness and improving adherence

    T2 - A round table discussion of the APMEN Vivax Working Group

    AU - Thriemer, Kamala

    AU - Bobogare, Albino

    AU - Ley, Benedikt

    AU - Gudo, Clarice Samo

    AU - Alam, Mohammad Shafiul

    AU - Anstey, Nick M.

    AU - Ashley, Elizabeth

    AU - Baird, J. Kevin

    AU - Gryseels, Charlotte

    AU - Jambert, Elodie

    AU - Lacerda, Marcus

    AU - Laihad, Ferdinand

    AU - Marfurt, Jutta

    AU - Pasaribu, Ayodhia Pitaloka

    AU - Poespoprodjo, Jeanne Rini

    AU - Sutanto, Inge

    AU - Taylor, Walter R.

    AU - Van Den Boogaard, Christel

    AU - Battle, Katherine E.

    AU - Dysoley, Lek

    AU - Ghimire, Prakash

    AU - Hawley, Bill

    AU - Hwang, Jimee

    AU - Khan, Wasif Ali

    AU - Mudin, Rose Nani Binti

    AU - Sumiwi, Maria Endang

    AU - Ahmed, Rukhsana

    AU - Aktaruzzaman, M. M.

    AU - Awasthi, Kiran Raj

    AU - Bardaji, Azucena

    AU - Bell, David

    AU - Boaz, Leonard

    AU - Burdam, Faustina Helen

    AU - Chandramohan, Daniel

    AU - Cheng, Qin

    AU - Chindawongsa, Keobouphaphone

    AU - Culpepper, Janice

    AU - Das, Santasabuj

    AU - Deray, Raffy

    AU - Desai, Meghna

    AU - Domingo, Gonzalo

    AU - Duoquan, Wang

    AU - Duparc, Stephan

    AU - Floranita, Rustini

    AU - Gerth-Guyette, Emily

    AU - Howes, Rosalind E.

    AU - Hugo, Cecilia

    AU - Jagoe, George

    AU - Sariwati, Elvieda

    AU - Jhora, Sanya Tahmina

    AU - Jinwei, Wu

    AU - Karunajeewa, Harin

    AU - Kenangalem, Enny

    AU - Lal, Bibek Kumar

    AU - Landuwulang, Chandra

    AU - Le Perru, Emmanuel

    AU - Lee, Sang Eun

    AU - Makita, Leo Sora

    AU - McCarthy, James

    AU - Mekuria, Asrat

    AU - Mishra, Neelima

    AU - Naket, Esau

    AU - Nambanya, Simone

    AU - Nausien, Johnny

    AU - Duc, Thang Ngo

    AU - Thi, Thuan Nguyen

    AU - Noviyanti, Rinitis

    AU - Pfeffer, Daniel

    AU - Qi, Gao

    AU - Rahmalia, Annisa

    AU - Rogerson, Stephen

    AU - Samad, Iriani

    AU - Sattabongkot, Jetsumon

    AU - Satyagraha, Ari

    AU - Shanks, Dennis

    AU - Sharma, Surender Nath

    AU - Sibley, Carol Hopkins

    AU - Sungkar, Ali

    AU - Syafruddin, Din

    AU - Talukdar, Arunansu

    AU - Tarning, Joel

    AU - Ter Kuile, Feiko

    AU - Thapa, Suman

    AU - Theodora, Minerva

    AU - Huy, Tho Tran

    AU - Waramin, Edward

    AU - Waramori, Govert

    AU - Woyessa, Adugna

    AU - Wongsrichanalai, Chansuda

    AU - Xa, Nguyen Xuan

    AU - Yeom, Joon Sup

    AU - Hermawan, Lukas

    AU - Devine, Angela

    AU - Nowak, Spike

    AU - Jaya, Indra

    AU - Supargiyono, Supargiyono

    AU - Grietens, Koen Peeters

    AU - Price, Ric N.

    PY - 2018/6/20

    Y1 - 2018/6/20

    N2 - The goal to eliminate malaria from the Asia-Pacific by 2030 will require the safe and widespread delivery of effective radical cure of malaria. In October 2017, the Asia Pacific Malaria Elimination Network Vivax Working Group met to discuss the impediments to primaquine (PQ) radical cure, how these can be overcome and the methodological difficulties in assessing clinical effectiveness of radical cure. The salient discussions of this meeting which involved 110 representatives from 18 partner countries and 21 institutional partner organizations are reported. Context specific strategies to improve adherence are needed to increase understanding and awareness of PQ within affected communities; these must include education and health promotion programs. Lessons learned from other disease programs highlight that a package of approaches has the greatest potential to change patient and prescriber habits, however optimizing the components of this approach and quantifying their effectiveness is challenging. In a trial setting, the reactivity of participants results in patients altering their behaviour and creates inherent bias. Although bias can be reduced by integrating data collection into the routine health care and surveillance systems, this comes at a cost of decreasing the detection of clinical outcomes. Measuring adherence and the factors that relate to it, also requires an in-depth understanding of the context and the underlying sociocultural logic that supports it. Reaching the elimination goal will require innovative approaches to improve radical cure for vivax malaria, as well as the methods to evaluate its effectiveness.

    AB - The goal to eliminate malaria from the Asia-Pacific by 2030 will require the safe and widespread delivery of effective radical cure of malaria. In October 2017, the Asia Pacific Malaria Elimination Network Vivax Working Group met to discuss the impediments to primaquine (PQ) radical cure, how these can be overcome and the methodological difficulties in assessing clinical effectiveness of radical cure. The salient discussions of this meeting which involved 110 representatives from 18 partner countries and 21 institutional partner organizations are reported. Context specific strategies to improve adherence are needed to increase understanding and awareness of PQ within affected communities; these must include education and health promotion programs. Lessons learned from other disease programs highlight that a package of approaches has the greatest potential to change patient and prescriber habits, however optimizing the components of this approach and quantifying their effectiveness is challenging. In a trial setting, the reactivity of participants results in patients altering their behaviour and creates inherent bias. Although bias can be reduced by integrating data collection into the routine health care and surveillance systems, this comes at a cost of decreasing the detection of clinical outcomes. Measuring adherence and the factors that relate to it, also requires an in-depth understanding of the context and the underlying sociocultural logic that supports it. Reaching the elimination goal will require innovative approaches to improve radical cure for vivax malaria, as well as the methods to evaluate its effectiveness.

    KW - Adherence

    KW - APMEN

    KW - Effectiveness

    KW - Efficacy

    KW - Plasmodium vivax

    KW - Primaquine

    KW - Radical cure

    KW - Vivax malaria

    UR - http://www.scopus.com/inward/record.url?scp=85048745928&partnerID=8YFLogxK

    U2 - 10.1186/s12936-018-2380-8

    DO - 10.1186/s12936-018-2380-8

    M3 - Meeting Abstract

    VL - 17

    SP - 1

    EP - 7

    JO - Malaria Journal

    JF - Malaria Journal

    SN - 1475-2875

    M1 - 241

    ER -