Quinolines as chemotherapeutic agents for leishmaniasis

Kristie A. Reynolds, Wendy A. Loughlin, David J. Young

Research output: Contribution to journalReview articlepeer-review

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Abstract

The development of leishmanicidal quinolines and their in vitro (promastigote and amastigote) and, where applicable, in vivo activities are reviewed. This survey provides a direct comparison of bioactivity across different species (e.g. L. donovani, L. amazonensis, L. chagasi, L infantum), and in different animal models (e.g. L. donovani Balb/c mice and L. donovani infected hamsters). The progress of selected quinolines through pre-clinical development and phase I/II trials, and the lead quinoline drugs sitamaquinine and Imiquimod, are discussed in conjunction with delivery systems and combination therapies.

Original languageEnglish
Pages (from-to)730-743
Number of pages14
JournalMini-Reviews in Medicinal Chemistry
Volume13
Issue number5
DOIs
Publication statusPublished - 21 May 2013
Externally publishedYes

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