Research connecting the 'Global South' and 'Global North' is not new to HCI. However, over the last few years we have seen a prominent shift in the ways we understand, represent and engage in North-South collaborations. Central to these discussions is the need to re-frame the nature of collaboration between and across geographies in which power dynamics, coloniality and the handling of differences are at the fore. In this panel, we will discuss experiences of HCI collaboration across the 'Global South' and 'Global North'. The panel will unpack the joys, fluidity and tensions within such collaborations from various geographical perspectives, in an effort to de-homogenize the Global South, and provide ways forward for an HCI flavored re-articulation of collaboration across geo-politically established and epistemic borders.