@article{b9d34a873f174a8c993f34912eccb7a5,
title = "Reduced in vitro activity of ceftaroline by Etest among clonal complex 239 methicillin-resistant Staphylococcus aureus clinical strains from Australia",
abstract = "A total of 421 methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates were tested for ceftaroline susceptibility by Etest (bioMeux). A multidrug resistant phenotype was found in 40.9%, and clonal complex 239 (CC239) was found in 33.5%. Ceftaroline nonsusceptibility (MIC, > 1.0 ?g/ml) was 16.9% overall. Nonsusceptibility was significantly higher in CC239 (41.1%, 58/141) and in isolates with a multidrug resistant phenotype (35.5%, 61/172) compared with comparators (P<0.0001). Nonsusceptibility of common multidrug resistant MRSA clones limits the empirical use of ceftaroline for these infections. ",
keywords = "avibactam, ceftaroline, ciprofloxacin, clindamycin, cotrimoxazole, erythromycin, gentamicin, tetracycline, vancomycin, antibiotic resistance, antibiotic sensitivity, Article, Australia, bacterial strain, bacterium isolate, clonal species, controlled study, drug efficacy, epsilometer test, in vitro study, methicillin resistant Staphylococcus aureus, MIC50, MIC90, nonhuman, phenotype, priority journal",
author = "Abbott, {I. J.} and Jenney, {A. W. J.} and Cameron Jeremiah and M. Mir{\"A}eta and Kandiah, {J P} and Deborah Holt and Steven Tong and Denis Spelman",
year = "2015",
month = dec,
doi = "10.1128/AAC.02015-15",
language = "English",
volume = "59",
pages = "7837--7841",
journal = "Antimicrobial Agents and Chemotherapy",
issn = "0066-4804",
publisher = "American Society for Microbiology",
number = "12",
}