Reduced in vitro activity of ceftaroline by Etest among clonal complex 239 methicillin-resistant Staphylococcus aureus clinical strains from Australia

I. J. Abbott; A. W. J. Jenney; Cameron Jeremiah; M. MirÄeta; J P Kandiah; Deborah Holt; Steven Tong; Denis Spelman

doi:10.1128/AAC.02015-15

Reduced in vitro activity of ceftaroline by Etest among clonal complex 239 methicillin-resistant Staphylococcus aureus clinical strains from Australia

I. J. Abbott, A. W. J. Jenney, Cameron Jeremiah, M. MirÄeta, J P Kandiah, Deborah Holt, Steven Tong, Denis Spelman

Global and Tropical Health

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Abstract

A total of 421 methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates were tested for ceftaroline susceptibility by Etest (bioMeux). A multidrug resistant phenotype was found in 40.9%, and clonal complex 239 (CC239) was found in 33.5%. Ceftaroline nonsusceptibility (MIC, > 1.0 ?g/ml) was 16.9% overall. Nonsusceptibility was significantly higher in CC239 (41.1%, 58/141) and in isolates with a multidrug resistant phenotype (35.5%, 61/172) compared with comparators (P<0.0001). Nonsusceptibility of common multidrug resistant MRSA clones limits the empirical use of ceftaroline for these infections.

Original language	English
Pages (from-to)	7837-7841
Number of pages	5
Journal	Antimicrobial Agents and Chemotherapy
Volume	59
Issue number	12
DOIs	https://doi.org/10.1128/AAC.02015-15
Publication status	Published - Dec 2015

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title = "Reduced in vitro activity of ceftaroline by Etest among clonal complex 239 methicillin-resistant Staphylococcus aureus clinical strains from Australia",

abstract = "A total of 421 methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates were tested for ceftaroline susceptibility by Etest (bioMeux). A multidrug resistant phenotype was found in 40.9\%, and clonal complex 239 (CC239) was found in 33.5\%. Ceftaroline nonsusceptibility (MIC, > 1.0 ?g/ml) was 16.9\% overall. Nonsusceptibility was significantly higher in CC239 (41.1\%, 58/141) and in isolates with a multidrug resistant phenotype (35.5\%, 61/172) compared with comparators (P<0.0001). Nonsusceptibility of common multidrug resistant MRSA clones limits the empirical use of ceftaroline for these infections. ",

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author = "Abbott, \{I. J.\} and Jenney, \{A. W. J.\} and Cameron Jeremiah and M. Mir{\"A}eta and Kandiah, \{J P\} and Deborah Holt and Steven Tong and Denis Spelman",

year = "2015",

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doi = "10.1128/AAC.02015-15",

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T1 - Reduced in vitro activity of ceftaroline by Etest among clonal complex 239 methicillin-resistant Staphylococcus aureus clinical strains from Australia

AU - Abbott, I. J.

AU - Jenney, A. W. J.

AU - Jeremiah, Cameron

AU - MirÄeta, M.

AU - Kandiah, J P

AU - Holt, Deborah

AU - Tong, Steven

AU - Spelman, Denis

PY - 2015/12

Y1 - 2015/12

N2 - A total of 421 methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates were tested for ceftaroline susceptibility by Etest (bioMeux). A multidrug resistant phenotype was found in 40.9%, and clonal complex 239 (CC239) was found in 33.5%. Ceftaroline nonsusceptibility (MIC, > 1.0 ?g/ml) was 16.9% overall. Nonsusceptibility was significantly higher in CC239 (41.1%, 58/141) and in isolates with a multidrug resistant phenotype (35.5%, 61/172) compared with comparators (P<0.0001). Nonsusceptibility of common multidrug resistant MRSA clones limits the empirical use of ceftaroline for these infections.

AB - A total of 421 methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates were tested for ceftaroline susceptibility by Etest (bioMeux). A multidrug resistant phenotype was found in 40.9%, and clonal complex 239 (CC239) was found in 33.5%. Ceftaroline nonsusceptibility (MIC, > 1.0 ?g/ml) was 16.9% overall. Nonsusceptibility was significantly higher in CC239 (41.1%, 58/141) and in isolates with a multidrug resistant phenotype (35.5%, 61/172) compared with comparators (P<0.0001). Nonsusceptibility of common multidrug resistant MRSA clones limits the empirical use of ceftaroline for these infections.

KW - avibactam

KW - ceftaroline

KW - ciprofloxacin

KW - clindamycin

KW - cotrimoxazole

KW - erythromycin

KW - gentamicin

KW - tetracycline

KW - vancomycin

KW - antibiotic resistance

KW - antibiotic sensitivity

KW - Article

KW - Australia

KW - bacterial strain

KW - bacterium isolate

KW - clonal species

KW - controlled study

KW - drug efficacy

KW - epsilometer test

KW - in vitro study

KW - methicillin resistant Staphylococcus aureus

KW - MIC50

KW - MIC90

KW - nonhuman

KW - phenotype

KW - priority journal

UR - https://www.scopus.com/pages/publications/84954475513

U2 - 10.1128/AAC.02015-15

DO - 10.1128/AAC.02015-15

M3 - Article

C2 - PubMed:26392488

SN - 0066-4804

VL - 59

SP - 7837

EP - 7841

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 12

ER -

Reduced in vitro activity of ceftaroline by Etest among clonal complex 239 methicillin-resistant Staphylococcus aureus clinical strains from Australia

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