Reduced Red Blood Cell Deformability in Vivax Malaria

Jeyamalar T.Thurai Rathnam; Matthew J. Grigg; Arjen M. Dondorp; Timothy William; Megha Rajasekhar; Giri Rajahram; Julie A. Simpson; Bridget E. Barber; Nicholas M. Anstey

doi:10.1093/infdis/jiae490

Reduced Red Blood Cell Deformability in Vivax Malaria

Jeyamalar T.Thurai Rathnam, Matthew J. Grigg, Arjen M. Dondorp, Timothy William, Megha Rajasekhar, Giri Rajahram, Julie A. Simpson, Bridget E. Barber, Nicholas M. Anstey

Global and Tropical Health

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Abstract

Reduced deformability of both infected and uninfected red blood cells (RBCs) contributes to pathogenesis in Plasmodium falciparum malaria. Whole-blood RBC deformability (RBC-D) is not well characterized in Plasmodium vivax malaria. We used a laser-assisted optical rotational cell analyzer to measure the RBC-D in fresh whole-blood samples from Malaysian patients with vivax malaria (n = 25). Deformability of whole-blood RBCs, the vast majority of which were uninfected, was reduced in vivax malaria compared with controls (n = 15), though not to the same degree as in falciparum malaria (n = 90). Reduced RBC-D may contribute to the pathogenesis of vivax malaria, including splenic retention of uninfected RBCs.

Original language	English
Pages (from-to)	e566-e569
Number of pages	4
Journal	Journal of Infectious Diseases
Volume	231
Issue number	3
DOIs	https://doi.org/10.1093/infdis/jiae490
Publication status	Published - 15 Mar 2025

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Publisher Copyright:
© The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

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title = "Reduced Red Blood Cell Deformability in Vivax Malaria",

abstract = "Reduced deformability of both infected and uninfected red blood cells (RBCs) contributes to pathogenesis in Plasmodium falciparum malaria. Whole-blood RBC deformability (RBC-D) is not well characterized in Plasmodium vivax malaria. We used a laser-assisted optical rotational cell analyzer to measure the RBC-D in fresh whole-blood samples from Malaysian patients with vivax malaria (n = 25). Deformability of whole-blood RBCs, the vast majority of which were uninfected, was reduced in vivax malaria compared with controls (n = 15), though not to the same degree as in falciparum malaria (n = 90). Reduced RBC-D may contribute to the pathogenesis of vivax malaria, including splenic retention of uninfected RBCs.",

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AU - Rathnam, Jeyamalar T.Thurai

AU - Grigg, Matthew J.

AU - Dondorp, Arjen M.

AU - William, Timothy

AU - Rajasekhar, Megha

AU - Rajahram, Giri

AU - Simpson, Julie A.

AU - Barber, Bridget E.

AU - Anstey, Nicholas M.

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AB - Reduced deformability of both infected and uninfected red blood cells (RBCs) contributes to pathogenesis in Plasmodium falciparum malaria. Whole-blood RBC deformability (RBC-D) is not well characterized in Plasmodium vivax malaria. We used a laser-assisted optical rotational cell analyzer to measure the RBC-D in fresh whole-blood samples from Malaysian patients with vivax malaria (n = 25). Deformability of whole-blood RBCs, the vast majority of which were uninfected, was reduced in vivax malaria compared with controls (n = 15), though not to the same degree as in falciparum malaria (n = 90). Reduced RBC-D may contribute to the pathogenesis of vivax malaria, including splenic retention of uninfected RBCs.

KW - pathogenesis

KW - Plasmodium falciparum

KW - Plasmodium vivax

KW - red blood cell deformability

KW - spleen

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ER -

Reduced Red Blood Cell Deformability in Vivax Malaria

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