Reduction in Staphylococcus aureus bacteraemia rates in patients receiving haemodialysis following alteration of skin antisepsis procedures

BJ Stewart; T Gardiner; Greg J Perry; Steven Tong

doi:10.1016/j.jhin.2015.10.022

Reduction in Staphylococcus aureus bacteraemia rates in patients receiving haemodialysis following alteration of skin antisepsis procedures

BJ Stewart, T Gardiner, Greg J Perry, Steven Tong

Research output: Contribution to journal › Article › peer-review

Abstract

This study examined all cases of Staphylococcus aureus bacteraemia (SAB) in the haemodialysis cohort at the Royal Darwin Hospital, Australia over a seven-year period. Midway through this period, antisepsis for arteriovenous fistulae (AVF) and central venous catheters (CVC) changed from 0.5% chlorhexidine solution to 2% chlorhexidine solution. Rates of SAB episodes were calculated using registry data. Trends in SAB over time were analysed using an interrupted regression analysis. Following the change to 2% chlorhexidine, average SAB rates decreased by 68%, and it is estimated that 0.111 cases of SAB/patient-year were prevented. CVC-related SAB rates remained low throughout. These results support the use of 2% chlorhexidine in skin antisepsis for patients with AVF. � 2015 The Healthcare Infection Society.

Original language	English
Pages (from-to)	191-193
Number of pages	3
Journal	Journal of Hospital Infection
Volume	92
Issue number	2
DOIs	https://doi.org/10.1016/j.jhin.2015.10.022
Publication status	Published - 2016

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10.1016/j.jhin.2015.10.022

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title = "Reduction in Staphylococcus aureus bacteraemia rates in patients receiving haemodialysis following alteration of skin antisepsis procedures",

abstract = "This study examined all cases of Staphylococcus aureus bacteraemia (SAB) in the haemodialysis cohort at the Royal Darwin Hospital, Australia over a seven-year period. Midway through this period, antisepsis for arteriovenous fistulae (AVF) and central venous catheters (CVC) changed from 0.5% chlorhexidine solution to 2% chlorhexidine solution. Rates of SAB episodes were calculated using registry data. Trends in SAB over time were analysed using an interrupted regression analysis. Following the change to 2% chlorhexidine, average SAB rates decreased by 68%, and it is estimated that 0.111 cases of SAB/patient-year were prevented. CVC-related SAB rates remained low throughout. These results support the use of 2% chlorhexidine in skin antisepsis for patients with AVF. � 2015 The Healthcare Infection Society.",

keywords = "chlorhexidine, antisepsis, arteriovenous fistula, Article, Australia, catheter infection, central venous catheter, chemical composition, cohort analysis, disease registry, hemodialysis, hemodialysis patient, hospital patient, human, incidence, major clinical study, retrospective study, skin decontamination, staphylococcal bacteremia",

author = "BJ Stewart and T Gardiner and Perry, {Greg J} and Steven Tong",

year = "2016",

doi = "10.1016/j.jhin.2015.10.022",

language = "English",

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AU - Stewart, BJ

AU - Gardiner, T

AU - Perry, Greg J

AU - Tong, Steven

PY - 2016

Y1 - 2016

N2 - This study examined all cases of Staphylococcus aureus bacteraemia (SAB) in the haemodialysis cohort at the Royal Darwin Hospital, Australia over a seven-year period. Midway through this period, antisepsis for arteriovenous fistulae (AVF) and central venous catheters (CVC) changed from 0.5% chlorhexidine solution to 2% chlorhexidine solution. Rates of SAB episodes were calculated using registry data. Trends in SAB over time were analysed using an interrupted regression analysis. Following the change to 2% chlorhexidine, average SAB rates decreased by 68%, and it is estimated that 0.111 cases of SAB/patient-year were prevented. CVC-related SAB rates remained low throughout. These results support the use of 2% chlorhexidine in skin antisepsis for patients with AVF. � 2015 The Healthcare Infection Society.

AB - This study examined all cases of Staphylococcus aureus bacteraemia (SAB) in the haemodialysis cohort at the Royal Darwin Hospital, Australia over a seven-year period. Midway through this period, antisepsis for arteriovenous fistulae (AVF) and central venous catheters (CVC) changed from 0.5% chlorhexidine solution to 2% chlorhexidine solution. Rates of SAB episodes were calculated using registry data. Trends in SAB over time were analysed using an interrupted regression analysis. Following the change to 2% chlorhexidine, average SAB rates decreased by 68%, and it is estimated that 0.111 cases of SAB/patient-year were prevented. CVC-related SAB rates remained low throughout. These results support the use of 2% chlorhexidine in skin antisepsis for patients with AVF. � 2015 The Healthcare Infection Society.

KW - chlorhexidine

KW - antisepsis

KW - arteriovenous fistula

KW - Article

KW - Australia

KW - catheter infection

KW - central venous catheter

KW - chemical composition

KW - cohort analysis

KW - disease registry

KW - hemodialysis

KW - hemodialysis patient

KW - hospital patient

KW - human

KW - incidence

KW - major clinical study

KW - retrospective study

KW - skin decontamination

KW - staphylococcal bacteremia

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DO - 10.1016/j.jhin.2015.10.022

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VL - 92

SP - 191

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JO - Journal of Hospital Infection

JF - Journal of Hospital Infection

SN - 0195-6701

IS - 2

ER -

Reduction in Staphylococcus aureus bacteraemia rates in patients receiving haemodialysis following alteration of skin antisepsis procedures

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