Abstract
Previous studies investigating the relationship between sodium intake and blood pressure have mostly relied on dietary recall and clinic blood pressure measurement. In this cross-sectional study, we aimed to investigate the relationship between 24 hour urinary sodium and potassium excretion, and their ratio, with 24 hour ambulatory blood pressure parameters including nocturnal blood pressure dipping in patients with type 1 and 2 diabetes. We report that in 116 patients with diabetes, systolic blood pressure was significantly predicted by the time of day, age, the interaction between dipping status with time, and 24 hour urinary sodium-to-potassium ratio (R2 = 0.83) with a relative contribution of 53%, 21%, 20% and 6%, respectively. However, there was no interaction between urinary sodium-to-potassium ratio and dipping status.
| Original language | English |
|---|---|
| Pages (from-to) | 94-97 |
| Number of pages | 4 |
| Journal | Clinical and Experimental Pharmacology and Physiology |
| Volume | 45 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1 Jan 2018 |
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Relationship between urinary sodium-to-potassium ratio and ambulatory blood pressure in patients with diabetes mellitus. / Libianto, Renata; Moran, John; O'Callaghan, Christopher; Baqar, Sara; Chen, Angela X.; Baker, Scott T.; Clarke, Michelle; MacIsaac, Richard J.; Jerums, George; Ekinci, Elif I.
In: Clinical and Experimental Pharmacology and Physiology, Vol. 45, No. 1, 01.01.2018, p. 94-97.Research output: Contribution to journal › Letter › Research › peer-review
TY - JOUR
T1 - Relationship between urinary sodium-to-potassium ratio and ambulatory blood pressure in patients with diabetes mellitus
AU - Libianto, Renata
AU - Moran, John
AU - O'Callaghan, Christopher
AU - Baqar, Sara
AU - Chen, Angela X.
AU - Baker, Scott T.
AU - Clarke, Michelle
AU - MacIsaac, Richard J.
AU - Jerums, George
AU - Ekinci, Elif I.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Previous studies investigating the relationship between sodium intake and blood pressure have mostly relied on dietary recall and clinic blood pressure measurement. In this cross-sectional study, we aimed to investigate the relationship between 24 hour urinary sodium and potassium excretion, and their ratio, with 24 hour ambulatory blood pressure parameters including nocturnal blood pressure dipping in patients with type 1 and 2 diabetes. We report that in 116 patients with diabetes, systolic blood pressure was significantly predicted by the time of day, age, the interaction between dipping status with time, and 24 hour urinary sodium-to-potassium ratio (R2 = 0.83) with a relative contribution of 53%, 21%, 20% and 6%, respectively. However, there was no interaction between urinary sodium-to-potassium ratio and dipping status.
AB - Previous studies investigating the relationship between sodium intake and blood pressure have mostly relied on dietary recall and clinic blood pressure measurement. In this cross-sectional study, we aimed to investigate the relationship between 24 hour urinary sodium and potassium excretion, and their ratio, with 24 hour ambulatory blood pressure parameters including nocturnal blood pressure dipping in patients with type 1 and 2 diabetes. We report that in 116 patients with diabetes, systolic blood pressure was significantly predicted by the time of day, age, the interaction between dipping status with time, and 24 hour urinary sodium-to-potassium ratio (R2 = 0.83) with a relative contribution of 53%, 21%, 20% and 6%, respectively. However, there was no interaction between urinary sodium-to-potassium ratio and dipping status.
KW - ambulatory blood pressure
KW - diabetes
KW - potassium
KW - sodium
KW - urinary electrolytes
UR - http://www.scopus.com/inward/record.url?scp=85037707140&partnerID=8YFLogxK
U2 - 10.1111/1440-1681.12852
DO - 10.1111/1440-1681.12852
M3 - Letter
VL - 45
SP - 94
EP - 97
JO - Clinical and Experimental Pharmacology and Physiology
JF - Clinical and Experimental Pharmacology and Physiology
SN - 0305-1870
IS - 1
ER -