Relationship of circulating Plasmodium falciparum lifecycle stage to circulating parasitemia and total parasite biomass

Michael F. Duffy; Gerry Q. Tonkin-Hill; Leily Trianty; Rintis Noviyanti; Hanh H.T. Nguyen; Janavi S. Rambhatla; Malcolm J. McConville; Stephen J. Rogerson; Graham V. Brown; Ric N. Price; Nicholas M. Anstey; Karen P. Day; Anthony T. Papenfuss

doi:10.1038/s41467-022-32996-5

Relationship of circulating Plasmodium falciparum lifecycle stage to circulating parasitemia and total parasite biomass

Michael F. Duffy, Gerry Q. Tonkin-Hill, Leily Trianty, Rintis Noviyanti, Hanh H.T. Nguyen, Janavi S. Rambhatla, Malcolm J. McConville, Stephen J. Rogerson, Graham V. Brown, Ric N. Price, Nicholas M. Anstey, Karen P. Day, Anthony T. Papenfuss

Global and Tropical Health

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Abstract

We previously showed in Papua that circulating Plasmodium falciparum causing severe malaria are younger than those causing uncomplicated malaria. Thomson-Luque et al. subsequently claimed that in ours, and other datasets, circulating parasitemia inversely correlated with estimated parasite age and that this was because the P. falciparum that cause severe malaria express PfEMP1s that are more cytoadherent, leading to earlier parasite sequestration in the microvasculature and reduced splenic clearance. Here, we show that in our dataset circulating parasitemia and the proportion of total parasites that are circulating do not correlate with circulating parasite age, hence our data do not support their hypothesis.

Original language	English
Article number	5557
Pages (from-to)	1-3
Number of pages	3
Journal	Nature Communications
Volume	13
Issue number	1
DOIs	https://doi.org/10.1038/s41467-022-32996-5
Publication status	Published - 23 Sept 2022

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Duffy, M. F., Tonkin-Hill, G. Q., Trianty, L., Noviyanti, R., Nguyen, H. H. T., Rambhatla, J. S., McConville, M. J., Rogerson, S. J., Brown, G. V., Price, R. N., Anstey, N. M., Day, K. P., & Papenfuss, A. T. (2022). Relationship of circulating Plasmodium falciparum lifecycle stage to circulating parasitemia and total parasite biomass. Nature Communications, 13(1), 1-3. Article 5557. https://doi.org/10.1038/s41467-022-32996-5

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title = "Relationship of circulating Plasmodium falciparum lifecycle stage to circulating parasitemia and total parasite biomass",

abstract = "We previously showed in Papua that circulating Plasmodium falciparum causing severe malaria are younger than those causing uncomplicated malaria. Thomson-Luque et al. subsequently claimed that in ours, and other datasets, circulating parasitemia inversely correlated with estimated parasite age and that this was because the P. falciparum that cause severe malaria express PfEMP1s that are more cytoadherent, leading to earlier parasite sequestration in the microvasculature and reduced splenic clearance. Here, we show that in our dataset circulating parasitemia and the proportion of total parasites that are circulating do not correlate with circulating parasite age, hence our data do not support their hypothesis.",

author = "Duffy, \{Michael F.\} and Tonkin-Hill, \{Gerry Q.\} and Leily Trianty and Rintis Noviyanti and Nguyen, \{Hanh H.T.\} and Rambhatla, \{Janavi S.\} and McConville, \{Malcolm J.\} and Rogerson, \{Stephen J.\} and Brown, \{Graham V.\} and Price, \{Ric N.\} and Anstey, \{Nicholas M.\} and Day, \{Karen P.\} and Papenfuss, \{Anthony T.\}",

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doi = "10.1038/s41467-022-32996-5",

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Duffy, MF, Tonkin-Hill, GQ, Trianty, L, Noviyanti, R, Nguyen, HHT, Rambhatla, JS, McConville, MJ, Rogerson, SJ, Brown, GV, Price, RN , Anstey, NM, Day, KP & Papenfuss, AT 2022, 'Relationship of circulating Plasmodium falciparum lifecycle stage to circulating parasitemia and total parasite biomass', Nature Communications, vol. 13, no. 1, 5557, pp. 1-3. https://doi.org/10.1038/s41467-022-32996-5

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T1 - Relationship of circulating Plasmodium falciparum lifecycle stage to circulating parasitemia and total parasite biomass

AU - Duffy, Michael F.

AU - Tonkin-Hill, Gerry Q.

AU - Trianty, Leily

AU - Noviyanti, Rintis

AU - Nguyen, Hanh H.T.

AU - Rambhatla, Janavi S.

AU - McConville, Malcolm J.

AU - Rogerson, Stephen J.

AU - Brown, Graham V.

AU - Price, Ric N.

AU - Anstey, Nicholas M.

AU - Day, Karen P.

AU - Papenfuss, Anthony T.

PY - 2022/9/23

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N2 - We previously showed in Papua that circulating Plasmodium falciparum causing severe malaria are younger than those causing uncomplicated malaria. Thomson-Luque et al. subsequently claimed that in ours, and other datasets, circulating parasitemia inversely correlated with estimated parasite age and that this was because the P. falciparum that cause severe malaria express PfEMP1s that are more cytoadherent, leading to earlier parasite sequestration in the microvasculature and reduced splenic clearance. Here, we show that in our dataset circulating parasitemia and the proportion of total parasites that are circulating do not correlate with circulating parasite age, hence our data do not support their hypothesis.

AB - We previously showed in Papua that circulating Plasmodium falciparum causing severe malaria are younger than those causing uncomplicated malaria. Thomson-Luque et al. subsequently claimed that in ours, and other datasets, circulating parasitemia inversely correlated with estimated parasite age and that this was because the P. falciparum that cause severe malaria express PfEMP1s that are more cytoadherent, leading to earlier parasite sequestration in the microvasculature and reduced splenic clearance. Here, we show that in our dataset circulating parasitemia and the proportion of total parasites that are circulating do not correlate with circulating parasite age, hence our data do not support their hypothesis.

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JO - Nature Communications

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Relationship of circulating Plasmodium falciparum lifecycle stage to circulating parasitemia and total parasite biomass

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