Respiratory microbiota: Addressing clinical questions, informing clinical practice

Geraint B. Rogers, Dominick Shaw, Robyn L. Marsh, Mary P. Carroll, David J. Serisier, Kenneth D. Bruce

    Research output: Contribution to journalReview article

    Abstract

    Over the last decade, technological advances have revolutionised efforts to understand the role played by microbes in airways disease. With the application of ever more sophisticated techniques, the literature has become increasingly inaccessible to the non-specialist reader, potentially hampering the translation of these gains into improvements in patient care. In this article, we set out the key principles underpinning microbiota research in respiratory contexts and provide practical guidance on how best such studies can be designed, executed and interpreted. We examine how an understanding of the respiratory microbiota both challenges fundamental assumptions and provides novel clinical insights into lung disease, and we set out a number of important targets for ongoing research.

    Original languageEnglish
    Pages (from-to)74-81
    Number of pages8
    JournalThorax
    Volume70
    Issue number1
    DOIs
    Publication statusPublished - 2015

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  • Cite this

    Rogers, G. B., Shaw, D., Marsh, R. L., Carroll, M. P., Serisier, D. J., & Bruce, K. D. (2015). Respiratory microbiota: Addressing clinical questions, informing clinical practice. Thorax, 70(1), 74-81. https://doi.org/10.1136/thoraxjnl-2014-205826