Room Temperature, Transition-Metal-Free Arylation of Alcohols with Aryl Bromides

Da Liang Zhu, Jie Li, Qi Wu, Yanqing Wang, David Young, Hong Xi Li

Research output: Contribution to journalArticlepeer-review

Abstract

Sodium t-butoxide promotes the efficient etherification of alcohols with aryl bromides at room temperature. This simple procedure has a broad substrate scope, providing a practical pathway to aryl alkyl ethers in good yields without the addition of any transition metal species.

Original languageEnglish
Pages (from-to)637-646
Number of pages10
JournalSynthesis (Germany)
Volume55
DOIs
Publication statusE-pub ahead of print - 2022

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