Scabies mite inactivated protease paralogues

K FISCHER, Deborah Holt, Bart Currie, Shelley Faye Walton, D KEMP

    Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

    Abstract

    Scabies is a disease of considerable importance in the developing world and among disadvantaged people such as the Aborigines in Australia, as it underlies streptococcal skin infections. It has been neglected at the molecular level until very recently. However, 43,776 expressed sequence tags have now been generated at the Australian Genome Research Facility from a cDNA library we constructed. Unexpectedly, in a search for homologues of house dust mite allergens among these sequences, we discovered large families of serine and cysteine protease genes with genetically inactivated catalytic sites. These are strong candidates for parasite defences against host immunity as we did not find them in a house dust mite cDNA library. Some possible modes of action are discussed. Crown Copyright � 2005.
    Original languageEnglish
    Title of host publicationStreptococci
    Subtitle of host publicationNew Insights into an Old Enemy
    EditorsKS Sriprakash
    Place of PublicationAmsterdam
    PublisherElsevier
    Pages85-88
    Number of pages4
    ISBN (Print)444522050
    Publication statusPublished - 2006

    Fingerprint

    dust mites
    scabies
    cDNA libraries
    mites
    proteinases
    research facilities
    indigenous peoples
    cysteine proteinases
    serine proteinases
    allergens
    expressed sequence tags
    skin (animal)
    active sites
    mechanism of action
    immunity
    parasites
    genome
    infection
    genes

    Cite this

    FISCHER, K., Holt, D., Currie, B., Walton, S. F., & KEMP, D. (2006). Scabies mite inactivated protease paralogues. In KS. Sriprakash (Ed.), Streptococci: New Insights into an Old Enemy (pp. 85-88). Amsterdam: Elsevier.
    FISCHER, K ; Holt, Deborah ; Currie, Bart ; Walton, Shelley Faye ; KEMP, D. / Scabies mite inactivated protease paralogues. Streptococci: New Insights into an Old Enemy. editor / KS Sriprakash. Amsterdam : Elsevier, 2006. pp. 85-88
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    title = "Scabies mite inactivated protease paralogues",
    abstract = "Scabies is a disease of considerable importance in the developing world and among disadvantaged people such as the Aborigines in Australia, as it underlies streptococcal skin infections. It has been neglected at the molecular level until very recently. However, 43,776 expressed sequence tags have now been generated at the Australian Genome Research Facility from a cDNA library we constructed. Unexpectedly, in a search for homologues of house dust mite allergens among these sequences, we discovered large families of serine and cysteine protease genes with genetically inactivated catalytic sites. These are strong candidates for parasite defences against host immunity as we did not find them in a house dust mite cDNA library. Some possible modes of action are discussed. Crown Copyright � 2005.",
    author = "K FISCHER and Deborah Holt and Bart Currie and Walton, {Shelley Faye} and D KEMP",
    year = "2006",
    language = "English",
    isbn = "444522050",
    pages = "85--88",
    editor = "KS Sriprakash",
    booktitle = "Streptococci",
    publisher = "Elsevier",
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    FISCHER, K, Holt, D, Currie, B, Walton, SF & KEMP, D 2006, Scabies mite inactivated protease paralogues. in KS Sriprakash (ed.), Streptococci: New Insights into an Old Enemy. Elsevier, Amsterdam, pp. 85-88.

    Scabies mite inactivated protease paralogues. / FISCHER, K; Holt, Deborah; Currie, Bart; Walton, Shelley Faye; KEMP, D.

    Streptococci: New Insights into an Old Enemy. ed. / KS Sriprakash. Amsterdam : Elsevier, 2006. p. 85-88.

    Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

    TY - CHAP

    T1 - Scabies mite inactivated protease paralogues

    AU - FISCHER, K

    AU - Holt, Deborah

    AU - Currie, Bart

    AU - Walton, Shelley Faye

    AU - KEMP, D

    PY - 2006

    Y1 - 2006

    N2 - Scabies is a disease of considerable importance in the developing world and among disadvantaged people such as the Aborigines in Australia, as it underlies streptococcal skin infections. It has been neglected at the molecular level until very recently. However, 43,776 expressed sequence tags have now been generated at the Australian Genome Research Facility from a cDNA library we constructed. Unexpectedly, in a search for homologues of house dust mite allergens among these sequences, we discovered large families of serine and cysteine protease genes with genetically inactivated catalytic sites. These are strong candidates for parasite defences against host immunity as we did not find them in a house dust mite cDNA library. Some possible modes of action are discussed. Crown Copyright � 2005.

    AB - Scabies is a disease of considerable importance in the developing world and among disadvantaged people such as the Aborigines in Australia, as it underlies streptococcal skin infections. It has been neglected at the molecular level until very recently. However, 43,776 expressed sequence tags have now been generated at the Australian Genome Research Facility from a cDNA library we constructed. Unexpectedly, in a search for homologues of house dust mite allergens among these sequences, we discovered large families of serine and cysteine protease genes with genetically inactivated catalytic sites. These are strong candidates for parasite defences against host immunity as we did not find them in a house dust mite cDNA library. Some possible modes of action are discussed. Crown Copyright � 2005.

    M3 - Chapter

    SN - 444522050

    SP - 85

    EP - 88

    BT - Streptococci

    A2 - Sriprakash, KS

    PB - Elsevier

    CY - Amsterdam

    ER -

    FISCHER K, Holt D, Currie B, Walton SF, KEMP D. Scabies mite inactivated protease paralogues. In Sriprakash KS, editor, Streptococci: New Insights into an Old Enemy. Amsterdam: Elsevier. 2006. p. 85-88