Scabies mite inactivated protease paralogues

K FISCHER, Deborah Holt, Bart Currie, Shelley Faye Walton, D KEMP

    Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


    Scabies is a disease of considerable importance in the developing world and among disadvantaged people such as the Aborigines in Australia, as it underlies streptococcal skin infections. It has been neglected at the molecular level until very recently. However, 43,776 expressed sequence tags have now been generated at the Australian Genome Research Facility from a cDNA library we constructed. Unexpectedly, in a search for homologues of house dust mite allergens among these sequences, we discovered large families of serine and cysteine protease genes with genetically inactivated catalytic sites. These are strong candidates for parasite defences against host immunity as we did not find them in a house dust mite cDNA library. Some possible modes of action are discussed. Crown Copyright � 2005.
    Original languageEnglish
    Title of host publicationStreptococci
    Subtitle of host publicationNew Insights into an Old Enemy
    EditorsKS Sriprakash
    Place of PublicationAmsterdam
    Number of pages4
    ISBN (Print)444522050
    Publication statusPublished - 2006


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