Scabies mite inactivated protease paralogues

K FISCHER, Deborah Holt, Bart Currie, Shelley Faye Walton, D KEMP

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

Abstract

Scabies is a disease of considerable importance in the developing world and among disadvantaged people such as the Aborigines in Australia, as it underlies streptococcal skin infections. It has been neglected at the molecular level until very recently. However, 43,776 expressed sequence tags have now been generated at the Australian Genome Research Facility from a cDNA library we constructed. Unexpectedly, in a search for homologues of house dust mite allergens among these sequences, we discovered large families of serine and cysteine protease genes with genetically inactivated catalytic sites. These are strong candidates for parasite defences against host immunity as we did not find them in a house dust mite cDNA library. Some possible modes of action are discussed. Crown Copyright � 2005.
Original languageEnglish
Title of host publicationStreptococci
Subtitle of host publicationNew Insights into an Old Enemy
EditorsKS Sriprakash
Place of PublicationAmsterdam
PublisherElsevier
Pages85-88
Number of pages4
ISBN (Print)444522050
Publication statusPublished - 2006

Fingerprint

dust mites
scabies
cDNA libraries
mites
proteinases
research facilities
indigenous peoples
cysteine proteinases
serine proteinases
allergens
expressed sequence tags
skin (animal)
active sites
mechanism of action
immunity
parasites
genome
infection
genes

Cite this

FISCHER, K., Holt, D., Currie, B., Walton, S. F., & KEMP, D. (2006). Scabies mite inactivated protease paralogues. In KS. Sriprakash (Ed.), Streptococci: New Insights into an Old Enemy (pp. 85-88). Amsterdam: Elsevier.
FISCHER, K ; Holt, Deborah ; Currie, Bart ; Walton, Shelley Faye ; KEMP, D. / Scabies mite inactivated protease paralogues. Streptococci: New Insights into an Old Enemy. editor / KS Sriprakash. Amsterdam : Elsevier, 2006. pp. 85-88
@inbook{8c34de4386804849b9a88535f57f5387,
title = "Scabies mite inactivated protease paralogues",
abstract = "Scabies is a disease of considerable importance in the developing world and among disadvantaged people such as the Aborigines in Australia, as it underlies streptococcal skin infections. It has been neglected at the molecular level until very recently. However, 43,776 expressed sequence tags have now been generated at the Australian Genome Research Facility from a cDNA library we constructed. Unexpectedly, in a search for homologues of house dust mite allergens among these sequences, we discovered large families of serine and cysteine protease genes with genetically inactivated catalytic sites. These are strong candidates for parasite defences against host immunity as we did not find them in a house dust mite cDNA library. Some possible modes of action are discussed. Crown Copyright � 2005.",
author = "K FISCHER and Deborah Holt and Bart Currie and Walton, {Shelley Faye} and D KEMP",
year = "2006",
language = "English",
isbn = "444522050",
pages = "85--88",
editor = "KS Sriprakash",
booktitle = "Streptococci",
publisher = "Elsevier",
address = "United Kingdom",

}

FISCHER, K, Holt, D, Currie, B, Walton, SF & KEMP, D 2006, Scabies mite inactivated protease paralogues. in KS Sriprakash (ed.), Streptococci: New Insights into an Old Enemy. Elsevier, Amsterdam, pp. 85-88.

Scabies mite inactivated protease paralogues. / FISCHER, K; Holt, Deborah; Currie, Bart; Walton, Shelley Faye; KEMP, D.

Streptococci: New Insights into an Old Enemy. ed. / KS Sriprakash. Amsterdam : Elsevier, 2006. p. 85-88.

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

TY - CHAP

T1 - Scabies mite inactivated protease paralogues

AU - FISCHER, K

AU - Holt, Deborah

AU - Currie, Bart

AU - Walton, Shelley Faye

AU - KEMP, D

PY - 2006

Y1 - 2006

N2 - Scabies is a disease of considerable importance in the developing world and among disadvantaged people such as the Aborigines in Australia, as it underlies streptococcal skin infections. It has been neglected at the molecular level until very recently. However, 43,776 expressed sequence tags have now been generated at the Australian Genome Research Facility from a cDNA library we constructed. Unexpectedly, in a search for homologues of house dust mite allergens among these sequences, we discovered large families of serine and cysteine protease genes with genetically inactivated catalytic sites. These are strong candidates for parasite defences against host immunity as we did not find them in a house dust mite cDNA library. Some possible modes of action are discussed. Crown Copyright � 2005.

AB - Scabies is a disease of considerable importance in the developing world and among disadvantaged people such as the Aborigines in Australia, as it underlies streptococcal skin infections. It has been neglected at the molecular level until very recently. However, 43,776 expressed sequence tags have now been generated at the Australian Genome Research Facility from a cDNA library we constructed. Unexpectedly, in a search for homologues of house dust mite allergens among these sequences, we discovered large families of serine and cysteine protease genes with genetically inactivated catalytic sites. These are strong candidates for parasite defences against host immunity as we did not find them in a house dust mite cDNA library. Some possible modes of action are discussed. Crown Copyright � 2005.

M3 - Chapter

SN - 444522050

SP - 85

EP - 88

BT - Streptococci

A2 - Sriprakash, KS

PB - Elsevier

CY - Amsterdam

ER -

FISCHER K, Holt D, Currie B, Walton SF, KEMP D. Scabies mite inactivated protease paralogues. In Sriprakash KS, editor, Streptococci: New Insights into an Old Enemy. Amsterdam: Elsevier. 2006. p. 85-88