@article{5bfd052c6dd3471bb62d0de6adeac447,
title = "Scabies: molecular perspectives and therapeutic implications in the face of emerging drug resistance",
abstract = "Limited effective treatments, coupled with recent observations of emerging drug resistance to oral ivermectin and 5% permethrin, raise concerns regarding the future control of scabies, especially in severe cases and in endemic areas where repeated community treatment programs are in place. There is consequently an urgent need to define molecular mechanisms of drug resistance in scabies mites and to develop and assess alternative therapeutic options, such as tea tree oil, in the event of increasing treatment failure. Molecular studies on scabies mites have, until recently, been restricted; however; recent advances are providing new insights into scabies mite biology and genetic mechanisms underlying drug resistance. These may assist in overcoming many of the current difficulties in monitoring treatment efficacy and allow the development of more sensitive tools for monitoring emerging resistance. � 2008 Future Medicine Ltd.",
keywords = "acaricide, benzyl benzoate, camphor, complementary DNA, crotamiton, essential oil, genomic DNA, ivermectin, lindane, Lippia multiflora extract, messenger RNA, neem oil, permethrin, petroleum, plant extract, sulfur, tea tree oil, topical agent, turmeric, unclassified drug, insecticide, antibacterial activity, childhood disease, clinical trial, cream, dizziness, DNA sequence, drug absorption, drug approval, drug choice, drug contraindication, drug dose regimen, drug efficacy, drug potency, drug safety, drug substitution, drug tolerability, drug treatment failure, drug withdrawal, genetic analysis, genetic association, genetic variability, health care cost, host resistance, human, infestation, lippia multiflora, medicinal plant, molecular mechanics, muscle cramp, neurotoxicity, newborn infection, nonhuman, paresthesia, pathogenesis, pregnancy, priority journal, recurrence risk, retreatment, review, Sarcoptes scabiei, scabies, seizure, single drug dose, skin irritation, symptomatology, animal, drug effect, drug resistance, Melaleuca alternifolia, Psoroptes cervinus, Animals, Drug Resistance, Humans, Insecticides, Ivermectin, Permethrin, Scabies, Tea Tree Oil",
author = "Kate Mounsey and Deborah Holt and James McCarthy and Bart Currie and Shelley Walton",
year = "2008",
language = "English",
volume = "3",
pages = "57--66",
journal = "Future Microbiology",
issn = "1746-0913",
publisher = "Taylor & Francis",
number = "1",
}