Serum uric acid and albumin levels and estimatedglomerular filtration rate: oxidative stress considerations

P Bwititi, Ezekiel (Uba) Nwose, Sharon Nielsen, Henk Ruven, Wouter Kalle, Ross Richards, E Butkowski

Research output: Contribution to journalArticlepeer-review

Abstract

Uric acid has both antioxidant and oxidant properties, is excreted by the kidney and is associated with development of kidney disease. Albumin, another antioxidant is also excreted by the kidney in some renal diseases. The association and correlation of serum uric acid, albumin and estimated glomerular filtration rate (eGFR) could indicate the potential of renal function testing in evaluation of oxidative stress. This preliminary retrospective study looked at data on eGFR and serum levels of uric acid and albumin in 274 patients (120 males and 154 females) with an average age of 60.1 years but did not take into account any existing conditions or medication. Serum albumin levels were reduced as eGFR decreased and an inverse relationship between eGFR and serum uric acid levels with a statistically significant but weak partial correlation was also observed after accounting for sex and age (r = -0.32; p < 0.001). A controlled study on oxidant/anti-oxidant capacity of uric acid and other metabolites and relate these to renal function could be performed and this could lead to an indication of oxidative damage to the kidneys.
Original languageEnglish
Pages (from-to)82-87
Number of pages6
JournalAustralian Journal of Medical Science
Volume33
Issue number3
Publication statusPublished - Aug 2012
Externally publishedYes

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