Abstract
Aims: To assess prevalence of severe hypoglycemia, awareness and symptoms of hypoglycemia, and their associations with self-monitoring of blood glucose.
Methods: Diabetes MILES-Australia Study participants completed validated questionnaires and study-specific items.
Results: Of 642 adults with type 1 diabetes, 21% reported ≥. 1 severe hypoglycemic event in the past six months, and 21% reported impaired awareness of hypoglycemia (IAH). Severe hypoglycemia was increased four-fold for those with IAH compared with intact awareness (1.4. ±. 3.9 versus 0.3. ±. 1.0). Of those with IAH, 92% perceived autonomic and 88% neuroglycopenic symptoms, albeit at lower glucose thresholds compared to people with intact awareness. Those with IAH were more likely to perceive both symptom types at the same glucose level or to perceive neuroglycopenic symptoms first (all p. <. 0.001). Eighteen percent with IAH treated hypoglycemia only when they perceived symptoms and another 18% only when their capillary glucose was <. 3.0. mmol/L.
Conclusions: One in five adults with type 1 diabetes had IAH or experienced severe hypoglycemia in the past six. months. Total loss of hypoglycemia symptoms was rare; most people with IAH retained autonomic symptoms, perceived at relatively low glucose levels. Frequent self-monitoring of blood glucose prompted early recognition and treatment of hypoglycemia, suggesting severe hypoglycemia risk can be minimized.
| Original language | English |
|---|---|
| Pages (from-to) | 577-582 |
| Number of pages | 6 |
| Journal | Journal of Diabetes and Its Complications |
| Volume | 31 |
| Issue number | 3 |
| Early online date | 27 Nov 2016 |
| DOIs | |
| Publication status | Published - 2017 |
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Severe hypoglycemia, impaired awareness of hypoglycemia, and self-monitoring in adults with type 1 diabetes : Results from Diabetes MILES-Australia. / Hendrieckx, Christel; Hagger, Virginia; Jenkins, Alicia; Skinner, Timothy Chas; Pouwer, Frans; Speight, Jane.
In: Journal of Diabetes and Its Complications, Vol. 31, No. 3, 2017, p. 577-582.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Severe hypoglycemia, impaired awareness of hypoglycemia, and self-monitoring in adults with type 1 diabetes
T2 - Results from Diabetes MILES-Australia
AU - Hendrieckx, Christel
AU - Hagger, Virginia
AU - Jenkins, Alicia
AU - Skinner, Timothy Chas
AU - Pouwer, Frans
AU - Speight, Jane
PY - 2017
Y1 - 2017
N2 - Aims: To assess prevalence of severe hypoglycemia, awareness and symptoms of hypoglycemia, and their associations with self-monitoring of blood glucose. Methods: Diabetes MILES-Australia Study participants completed validated questionnaires and study-specific items. Results: Of 642 adults with type 1 diabetes, 21% reported ≥. 1 severe hypoglycemic event in the past six months, and 21% reported impaired awareness of hypoglycemia (IAH). Severe hypoglycemia was increased four-fold for those with IAH compared with intact awareness (1.4. ±. 3.9 versus 0.3. ±. 1.0). Of those with IAH, 92% perceived autonomic and 88% neuroglycopenic symptoms, albeit at lower glucose thresholds compared to people with intact awareness. Those with IAH were more likely to perceive both symptom types at the same glucose level or to perceive neuroglycopenic symptoms first (all p. <. 0.001). Eighteen percent with IAH treated hypoglycemia only when they perceived symptoms and another 18% only when their capillary glucose was <. 3.0. mmol/L. Conclusions: One in five adults with type 1 diabetes had IAH or experienced severe hypoglycemia in the past six. months. Total loss of hypoglycemia symptoms was rare; most people with IAH retained autonomic symptoms, perceived at relatively low glucose levels. Frequent self-monitoring of blood glucose prompted early recognition and treatment of hypoglycemia, suggesting severe hypoglycemia risk can be minimized.
AB - Aims: To assess prevalence of severe hypoglycemia, awareness and symptoms of hypoglycemia, and their associations with self-monitoring of blood glucose. Methods: Diabetes MILES-Australia Study participants completed validated questionnaires and study-specific items. Results: Of 642 adults with type 1 diabetes, 21% reported ≥. 1 severe hypoglycemic event in the past six months, and 21% reported impaired awareness of hypoglycemia (IAH). Severe hypoglycemia was increased four-fold for those with IAH compared with intact awareness (1.4. ±. 3.9 versus 0.3. ±. 1.0). Of those with IAH, 92% perceived autonomic and 88% neuroglycopenic symptoms, albeit at lower glucose thresholds compared to people with intact awareness. Those with IAH were more likely to perceive both symptom types at the same glucose level or to perceive neuroglycopenic symptoms first (all p. <. 0.001). Eighteen percent with IAH treated hypoglycemia only when they perceived symptoms and another 18% only when their capillary glucose was <. 3.0. mmol/L. Conclusions: One in five adults with type 1 diabetes had IAH or experienced severe hypoglycemia in the past six. months. Total loss of hypoglycemia symptoms was rare; most people with IAH retained autonomic symptoms, perceived at relatively low glucose levels. Frequent self-monitoring of blood glucose prompted early recognition and treatment of hypoglycemia, suggesting severe hypoglycemia risk can be minimized.
KW - Impaired awareness of hypoglycemia
KW - Self-monitoring of blood glucose
KW - Severe hypoglycemia
KW - Symptom recognition
KW - Type 1 diabetes
UR - http://www.scopus.com/inward/record.url?scp=85008210332&partnerID=8YFLogxK
U2 - 10.1016/j.jdiacomp.2016.11.013
DO - 10.1016/j.jdiacomp.2016.11.013
M3 - Article
VL - 31
SP - 577
EP - 582
JO - Journal of Diabetes and Its Complications
JF - Journal of Diabetes and Its Complications
SN - 1056-8727
IS - 3
ER -