Short Report: Reversibility of Retinal Microvascular Changes in Severe Falciparum Malaria

Richard Maude; Hugh William Fluellen Kingston; Sonia Joshi; Sanjib Mohanty; Saroj Mishra; Nicholas J White; Arjen Dondorp

doi:10.4269/ajtmh.14-0116

Short Report: Reversibility of Retinal Microvascular Changes in Severe Falciparum Malaria

Richard Maude, Hugh William Fluellen Kingston, Sonia Joshi, Sanjib Mohanty, Saroj Mishra, Nicholas J White, Arjen Dondorp

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Abstract

Malarial retinopathy allows detailed study of central nervous system vascular pathology in living patients with severe malaria. An adult with cerebral malaria is described who had prominent retinal whitening with corresponding retinal microvascular obstruction, vessel dilatation, increased vascular tortuosity, and blood retinal barrier leakage with decreased visual acuity, all of which resolved on recovery. Additional study of these features and their potential role in elucidating the pathogenesis of cerebral malaria is warranted.

Original language	English
Pages (from-to)	493-495
Number of pages	3
Journal	American Journal of Tropical Medicine and Hygiene
Volume	91
Issue number	3
DOIs	https://doi.org/10.4269/ajtmh.14-0116
Publication status	Published - 3 Sep 2014

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title = "Short Report: Reversibility of Retinal Microvascular Changes in Severe Falciparum Malaria",

abstract = "Malarial retinopathy allows detailed study of central nervous system vascular pathology in living patients with severe malaria. An adult with cerebral malaria is described who had prominent retinal whitening with corresponding retinal microvascular obstruction, vessel dilatation, increased vascular tortuosity, and blood retinal barrier leakage with decreased visual acuity, all of which resolved on recovery. Additional study of these features and their potential role in elucidating the pathogenesis of cerebral malaria is warranted.",

author = "Richard Maude and Kingston, {Hugh William Fluellen} and Sonia Joshi and Sanjib Mohanty and Saroj Mishra and White, {Nicholas J} and Arjen Dondorp",

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T2 - Reversibility of Retinal Microvascular Changes in Severe Falciparum Malaria

AU - Maude, Richard

AU - Kingston, Hugh William Fluellen

AU - Joshi, Sonia

AU - Mohanty, Sanjib

AU - Mishra, Saroj

AU - White, Nicholas J

AU - Dondorp, Arjen

PY - 2014/9/3

Y1 - 2014/9/3

N2 - Malarial retinopathy allows detailed study of central nervous system vascular pathology in living patients with severe malaria. An adult with cerebral malaria is described who had prominent retinal whitening with corresponding retinal microvascular obstruction, vessel dilatation, increased vascular tortuosity, and blood retinal barrier leakage with decreased visual acuity, all of which resolved on recovery. Additional study of these features and their potential role in elucidating the pathogenesis of cerebral malaria is warranted.

AB - Malarial retinopathy allows detailed study of central nervous system vascular pathology in living patients with severe malaria. An adult with cerebral malaria is described who had prominent retinal whitening with corresponding retinal microvascular obstruction, vessel dilatation, increased vascular tortuosity, and blood retinal barrier leakage with decreased visual acuity, all of which resolved on recovery. Additional study of these features and their potential role in elucidating the pathogenesis of cerebral malaria is warranted.

U2 - 10.4269/ajtmh.14-0116

DO - 10.4269/ajtmh.14-0116

M3 - Article

C2 - PubMed:24935949

VL - 91

SP - 493

EP - 495

JO - The American Journal of Tropical Medicine and Hygiene

JF - The American Journal of Tropical Medicine and Hygiene

SN - 0002-9637

IS - 3

ER -

Short Report: Reversibility of Retinal Microvascular Changes in Severe Falciparum Malaria

Abstract

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