Short report: Therapeutic efficacy of artemether-lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in Bangladesh

Rashidul Haque; Kamala Thriemer; Zhuxi Wang; Kimi Sato; Yukiko Wagatsuma; Mohammed Abdus Salam; Selim Akther; Jasmin Akter; Mark Fukuda; R. Scott Miller; Harald Noedl

doi:10.4269/ajtmh.2007.76.39

Short report: Therapeutic efficacy of artemether-lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in Bangladesh

Rashidul Haque, Kamala Thriemer, Zhuxi Wang, Kimi Sato, Yukiko Wagatsuma, Mohammed Abdus Salam, Selim Akther, Jasmin Akter, Mark Fukuda, R. Scott Miller, Harald Noedl

Research output: Contribution to journal › Article › peer-review

Abstract

Bangladesh faces increasing levels of chloroquine resistance, and drug sensitivity to sulfadoxine-pyremethamine is already compromised. Therefore, the Ministry of Health recently changed the national treatment guidelines to artemisinin-based combination therapies. The purpose of this study was to determine the baseline therapeutic efficacy of artemether-lumefantrine used as a six-dose regimen for the treatment of uncomplicated Plasmodium falciparum malaria. Sixty-seven patients were enrolled in the study; the cure rate in a 42-day follow-up after an adjustment by polymerase chain reaction was 94.3%. The treatment led to rapid fever (mean ± SD ± 25.82 ± 12.14 hours) and parasite (30.36 ± 19.43 hours) clearance. These data suggest that artemether-lumefantrine is a highly efficacious and well-tolerated treatment for uncomplicated P. falciparum malaria in Bangladesh.

Original language	English
Pages (from-to)	39-41
Number of pages	3
Journal	American Journal of Tropical Medicine and Hygiene
Volume	76
Issue number	1
DOIs	https://doi.org/10.4269/ajtmh.2007.76.39
Publication status	Published - Jan 2007
Externally published	Yes

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Haque, R., Thriemer, K., Wang, Z., Sato, K., Wagatsuma, Y., Salam, M. A., Akther, S., Akter, J., Fukuda, M., Miller, R. S., & Noedl, H. (2007). Short report: Therapeutic efficacy of artemether-lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in Bangladesh. American Journal of Tropical Medicine and Hygiene, 76(1), 39-41. https://doi.org/10.4269/ajtmh.2007.76.39

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title = "Short report: Therapeutic efficacy of artemether-lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in Bangladesh",

abstract = "Bangladesh faces increasing levels of chloroquine resistance, and drug sensitivity to sulfadoxine-pyremethamine is already compromised. Therefore, the Ministry of Health recently changed the national treatment guidelines to artemisinin-based combination therapies. The purpose of this study was to determine the baseline therapeutic efficacy of artemether-lumefantrine used as a six-dose regimen for the treatment of uncomplicated Plasmodium falciparum malaria. Sixty-seven patients were enrolled in the study; the cure rate in a 42-day follow-up after an adjustment by polymerase chain reaction was 94.3%. The treatment led to rapid fever (mean ± SD ± 25.82 ± 12.14 hours) and parasite (30.36 ± 19.43 hours) clearance. These data suggest that artemether-lumefantrine is a highly efficacious and well-tolerated treatment for uncomplicated P. falciparum malaria in Bangladesh.",

author = "Rashidul Haque and Kamala Thriemer and Zhuxi Wang and Kimi Sato and Yukiko Wagatsuma and Salam, {Mohammed Abdus} and Selim Akther and Jasmin Akter and Mark Fukuda and Miller, {R. Scott} and Harald Noedl",

year = "2007",

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doi = "10.4269/ajtmh.2007.76.39",

language = "English",

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Haque, R, Thriemer, K, Wang, Z, Sato, K, Wagatsuma, Y, Salam, MA, Akther, S, Akter, J, Fukuda, M, Miller, RS & Noedl, H 2007, 'Short report: Therapeutic efficacy of artemether-lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in Bangladesh', American Journal of Tropical Medicine and Hygiene, vol. 76, no. 1, pp. 39-41. https://doi.org/10.4269/ajtmh.2007.76.39

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T2 - Therapeutic efficacy of artemether-lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in Bangladesh

AU - Haque, Rashidul

AU - Thriemer, Kamala

AU - Wang, Zhuxi

AU - Sato, Kimi

AU - Wagatsuma, Yukiko

AU - Salam, Mohammed Abdus

AU - Akther, Selim

AU - Akter, Jasmin

AU - Fukuda, Mark

AU - Miller, R. Scott

AU - Noedl, Harald

PY - 2007/1

Y1 - 2007/1

N2 - Bangladesh faces increasing levels of chloroquine resistance, and drug sensitivity to sulfadoxine-pyremethamine is already compromised. Therefore, the Ministry of Health recently changed the national treatment guidelines to artemisinin-based combination therapies. The purpose of this study was to determine the baseline therapeutic efficacy of artemether-lumefantrine used as a six-dose regimen for the treatment of uncomplicated Plasmodium falciparum malaria. Sixty-seven patients were enrolled in the study; the cure rate in a 42-day follow-up after an adjustment by polymerase chain reaction was 94.3%. The treatment led to rapid fever (mean ± SD ± 25.82 ± 12.14 hours) and parasite (30.36 ± 19.43 hours) clearance. These data suggest that artemether-lumefantrine is a highly efficacious and well-tolerated treatment for uncomplicated P. falciparum malaria in Bangladesh.

AB - Bangladesh faces increasing levels of chloroquine resistance, and drug sensitivity to sulfadoxine-pyremethamine is already compromised. Therefore, the Ministry of Health recently changed the national treatment guidelines to artemisinin-based combination therapies. The purpose of this study was to determine the baseline therapeutic efficacy of artemether-lumefantrine used as a six-dose regimen for the treatment of uncomplicated Plasmodium falciparum malaria. Sixty-seven patients were enrolled in the study; the cure rate in a 42-day follow-up after an adjustment by polymerase chain reaction was 94.3%. The treatment led to rapid fever (mean ± SD ± 25.82 ± 12.14 hours) and parasite (30.36 ± 19.43 hours) clearance. These data suggest that artemether-lumefantrine is a highly efficacious and well-tolerated treatment for uncomplicated P. falciparum malaria in Bangladesh.

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Short report: Therapeutic efficacy of artemether-lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in Bangladesh

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