Short report: Therapeutic efficacy of artemether-lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in Bangladesh

Rashidul Haque, Kamala Thriemer, Zhuxi Wang, Kimi Sato, Yukiko Wagatsuma, Mohammed Abdus Salam, Selim Akther, Jasmin Akter, Mark Fukuda, R. Scott Miller, Harald Noedl

Research output: Contribution to journalArticlepeer-review

Abstract

Bangladesh faces increasing levels of chloroquine resistance, and drug sensitivity to sulfadoxine-pyremethamine is already compromised. Therefore, the Ministry of Health recently changed the national treatment guidelines to artemisinin-based combination therapies. The purpose of this study was to determine the baseline therapeutic efficacy of artemether-lumefantrine used as a six-dose regimen for the treatment of uncomplicated Plasmodium falciparum malaria. Sixty-seven patients were enrolled in the study; the cure rate in a 42-day follow-up after an adjustment by polymerase chain reaction was 94.3%. The treatment led to rapid fever (mean ± SD ± 25.82 ± 12.14 hours) and parasite (30.36 ± 19.43 hours) clearance. These data suggest that artemether-lumefantrine is a highly efficacious and well-tolerated treatment for uncomplicated P. falciparum malaria in Bangladesh.

Original languageEnglish
Pages (from-to)39-41
Number of pages3
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume76
Issue number1
DOIs
Publication statusPublished - Jan 2007
Externally publishedYes

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