TY - JOUR
T1 - Short-term DAPT after coronary stenting has similar ischemic and bleeding outcomes as long-term DAPT
T2 - A 5-year population-based cohort study
AU - Balaji Srinivasan, Sriraag
AU - Sehly, Amro
AU - Jaltotage, Biyanka
AU - Qin, Simon
AU - Ihdayhid, Abdul Rahman
AU - Marangou, James
AU - Rankin, James M.
AU - Sanfilippo, Frank M.
AU - Dwivedi, Girish
N1 - Funding Information:
Open Access funding enabled and organized by CAUL and its Member Institutions.
PY - 2023/8
Y1 - 2023/8
N2 - Background: Optimal duration of dual antiplatelet therapy (DAPT) following percutaneous coronary intervention (PCI) remains controversial. Aim: We investigated the relationship between DAPT duration following PCI and long-term ischemic and bleeding outcomes under real-world conditions. Methods: Patients aged ≥ 65 years who underwent PCI with stenting in Western Australian hospitals between 2003 and 2008 and survived 2 years were identified from linked hospital admissions data. The primary outcome was major adverse cardiovascular and cerebrovascular events (MACCE) defined as a composite of all-cause death and admissions for acute coronary syndrome (ACS), coronary artery revascularization procedure, stroke, and major bleeding. Secondary outcomes were ACS admissions, all-cause death, and major bleeding admissions. Patients were followed up for 5 years from initial PCI. Results: A total of 3963 patients were included in the final analysis. The mean age of the cohort was 74.5 ± 6.1 years with 67.3% males. No significant difference was seen with 6–12, 12–18, or 18–24 months DAPT, compared to 0–6 months DAPT duration for MACCE and all secondary outcomes at 3- and 5-year post-PCI. Conclusion: There is no significant difference in both bleeding and ischemic outcomes in long-term DAPT as compared to short-term DAPT for first- and second-generation drug-eluting stents in a real-world population.
AB - Background: Optimal duration of dual antiplatelet therapy (DAPT) following percutaneous coronary intervention (PCI) remains controversial. Aim: We investigated the relationship between DAPT duration following PCI and long-term ischemic and bleeding outcomes under real-world conditions. Methods: Patients aged ≥ 65 years who underwent PCI with stenting in Western Australian hospitals between 2003 and 2008 and survived 2 years were identified from linked hospital admissions data. The primary outcome was major adverse cardiovascular and cerebrovascular events (MACCE) defined as a composite of all-cause death and admissions for acute coronary syndrome (ACS), coronary artery revascularization procedure, stroke, and major bleeding. Secondary outcomes were ACS admissions, all-cause death, and major bleeding admissions. Patients were followed up for 5 years from initial PCI. Results: A total of 3963 patients were included in the final analysis. The mean age of the cohort was 74.5 ± 6.1 years with 67.3% males. No significant difference was seen with 6–12, 12–18, or 18–24 months DAPT, compared to 0–6 months DAPT duration for MACCE and all secondary outcomes at 3- and 5-year post-PCI. Conclusion: There is no significant difference in both bleeding and ischemic outcomes in long-term DAPT as compared to short-term DAPT for first- and second-generation drug-eluting stents in a real-world population.
KW - Bleeding
KW - DAPT
KW - Stenting
KW - Thrombosis
UR - http://www.scopus.com/inward/record.url?scp=85139148684&partnerID=8YFLogxK
U2 - 10.1007/s11845-022-03171-y
DO - 10.1007/s11845-022-03171-y
M3 - Article
C2 - 36173545
AN - SCOPUS:85139148684
SN - 0021-1265
VL - 192
SP - 1645
EP - 1647
JO - Irish Journal of Medical Science
JF - Irish Journal of Medical Science
IS - 4
ER -
