Some of the people, some of the time susceptibility to acute rheumatic fever

P BRYANT, Roy Robins-Browne, Jonathan Carapetis, Nigel Curtis

    Research output: Contribution to journalArticle

    Abstract

    Acute rheumatic fever is a major cause of heart disease in large parts of the world, but it remains unknown why only a small fraction of those who are infected with rheumatogenic group A streptococci develop an abnormal immune response that leads to acute rheumatic fever. An understanding of the mechanisms underlying host susceptibility can provide important insights into pathogenesis that in turn can inform new treatments. Extensive searches for susceptibility factors have been undertaken, including human leukocyte antigens, B-cell alloantigens, and cytokine genes. Although significant associations have been found between genetic factors and acute rheumatic fever, study results often conflict with each other. This review explores current understanding about host susceptibility to acute rheumatic fever and provides an overall perspective to the number of studies that have recently addressed this subject. � 2009 American Heart Association, Inc.
    Original languageEnglish
    Pages (from-to)742-753
    Number of pages12
    JournalCirculation
    Volume119
    Issue number5
    Publication statusPublished - 2009

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