Spectrum of renal disease in diabetes

Jessie Teng, Karen Dwyer, Prue Hill, Emily See, Elif Ekinci, George Jerums, Richard MacIsaac

    Research output: Contribution to journalArticleResearchpeer-review

    Abstract

    The spectrum of renal disease in patients with diabetes encompasses both diabetic kidney disease (including albuminuric and non-albuminuric phenotypes) and non-diabetic kidney disease. Diabetic kidney disease can manifest as varying degrees of renal insufficiency and albuminuria, with heterogeneity in histology reported on renal biopsy. For patients with diabetes and proteinuria, the finding of non-diabetic kidney disease alone or superimposed on the changes of diabetic nephropathy is increasingly reported. It is important to identify non-diabetic kidney disease as some forms are treatable, sometimes leading to remission. Clinical indications for a heightened suspicion of non-diabetic kidney disease and hence consideration for renal biopsy in patients with diabetes and nephropathy include absence of diabetic retinopathy, short duration of diabetes, atypical chronology, presence of haematuria or other systemic disease, and the nephrotic syndrome. Summary at a Glance This review article highlights the heterogeneity of renal disease in patients with diabetes. The spectrum of renal disease in patients with diabetes encompasses both diabetic kidney disease (including albuminuric and non-albuminuric phenotypes) and non-diabetic kidney disease which can be independent or superimposed on albuminuric diabetic kidney disease. It is important to identifying non-diabetic kidney disease because it is potentially reversible. The clinical features suggestive of non-diabetic kidney disease, which should prompt consideration of renal biopsy, are discussed.
    Original languageEnglish
    Pages (from-to)528-536
    Number of pages9
    JournalNephrology
    Volume19
    Issue number9
    DOIs
    Publication statusPublished - Sep 2014

    Fingerprint

    Kidney Diseases
    Diabetic Nephropathies
    Kidney
    Biopsy
    Phenotype
    Chronology
    Albuminuria
    Nephrotic Syndrome
    Diabetic Retinopathy
    Hematuria
    Proteinuria
    Renal Insufficiency
    Histology

    Cite this

    Teng, J., Dwyer, K., Hill, P., See, E., Ekinci, E., Jerums, G., & MacIsaac, R. (2014). Spectrum of renal disease in diabetes. Nephrology, 19(9), 528-536. https://doi.org/10.1111/nep.12288
    Teng, Jessie ; Dwyer, Karen ; Hill, Prue ; See, Emily ; Ekinci, Elif ; Jerums, George ; MacIsaac, Richard. / Spectrum of renal disease in diabetes. In: Nephrology. 2014 ; Vol. 19, No. 9. pp. 528-536.
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    Teng, J, Dwyer, K, Hill, P, See, E, Ekinci, E, Jerums, G & MacIsaac, R 2014, 'Spectrum of renal disease in diabetes', Nephrology, vol. 19, no. 9, pp. 528-536. https://doi.org/10.1111/nep.12288

    Spectrum of renal disease in diabetes. / Teng, Jessie; Dwyer, Karen; Hill, Prue; See, Emily; Ekinci, Elif; Jerums, George; MacIsaac, Richard.

    In: Nephrology, Vol. 19, No. 9, 09.2014, p. 528-536.

    Research output: Contribution to journalArticleResearchpeer-review

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    Teng J, Dwyer K, Hill P, See E, Ekinci E, Jerums G et al. Spectrum of renal disease in diabetes. Nephrology. 2014 Sep;19(9):528-536. https://doi.org/10.1111/nep.12288