Spotting sporotrichosis skin infection

The first Australian paediatric case series

Anna Schauer, Anita J. Campbell, Ian Arthur, Chris C. Blyth, Asha C. Bowen

    Research output: Contribution to journalArticleResearchpeer-review

    Abstract

    Aim: Sporotrichosis is a dermatomycosis caused by the dimorphic fungus, Sporothrix schenckii, with various outbreaks across Australia attributed to mouldy hay. Our objective was to investigate the clinical presentation and management of cutaneous sporotrichosis in a paediatric population of Western Australia. 

    Methods: A retrospective case review was performed for S. schenckii infections in children below 18 years, between January 2000 and November 2017. Cases were identified from the state-wide laboratory database and additional clinical data obtained from medical records. 

    Results: Thirty-two cases of microbiologically proven S. schenckii infection were identified, mostly from rural areas (n = 20, 63%). Complete clinical data were available for 11 cases (34%). The most common risk factors were exposure to farm animals and hay, arthropod bites and outdoor activities. The median duration from symptom onset to correct diagnosis was 6 weeks (interquartile range: 4–7 weeks). Most cases were initially treated with multiple, broad-spectrum antibacterial agents (n = 7, 64%). Targeted therapy (itraconazole) was used in all cases once the diagnosis was made, with a median treatment duration of 5 months (interquartile range: 4–6 months). Morbidity included scarring (n = 4, 31%), itraconazole associated diarrhoea (n = 1, 8%) and mild hepatotoxicity (n = 1, 8%). 

    Conclusion: Summarising the clinical experience of these cases is a useful guide for clinical recognition and may serve to shorten the interval between onset and diagnosis, and avoid the need for antibacterial therapy. These data highlight the importance of recognising Sporotrichosis in children outside an outbreak setting, leading to timely diagnosis and appropriate treatment with antifungal agents.

    Original languageEnglish
    Pages (from-to)1-3
    Number of pages3
    JournalJournal of Paediatrics and Child Health
    DOIs
    Publication statusE-pub ahead of print - 15 Oct 2019

    Fingerprint

    Sporotrichosis
    Metrorrhagia
    Pediatrics
    Skin
    Itraconazole
    Infection
    Disease Outbreaks
    Sporothrix
    Dermatomycoses
    Western Australia
    Arthropods
    Antifungal Agents
    Domestic Animals
    Bites and Stings
    Therapeutics
    Cicatrix
    Medical Records
    Diarrhea
    Fungi
    Databases

    Cite this

    Schauer, Anna ; Campbell, Anita J. ; Arthur, Ian ; Blyth, Chris C. ; Bowen, Asha C. / Spotting sporotrichosis skin infection : The first Australian paediatric case series. In: Journal of Paediatrics and Child Health. 2019 ; pp. 1-3.
    @article{31428b9faf314c668bd11e08351c0c10,
    title = "Spotting sporotrichosis skin infection: The first Australian paediatric case series",
    abstract = "Aim: Sporotrichosis is a dermatomycosis caused by the dimorphic fungus, Sporothrix schenckii, with various outbreaks across Australia attributed to mouldy hay. Our objective was to investigate the clinical presentation and management of cutaneous sporotrichosis in a paediatric population of Western Australia. Methods: A retrospective case review was performed for S. schenckii infections in children below 18 years, between January 2000 and November 2017. Cases were identified from the state-wide laboratory database and additional clinical data obtained from medical records. Results: Thirty-two cases of microbiologically proven S. schenckii infection were identified, mostly from rural areas (n = 20, 63{\%}). Complete clinical data were available for 11 cases (34{\%}). The most common risk factors were exposure to farm animals and hay, arthropod bites and outdoor activities. The median duration from symptom onset to correct diagnosis was 6 weeks (interquartile range: 4–7 weeks). Most cases were initially treated with multiple, broad-spectrum antibacterial agents (n = 7, 64{\%}). Targeted therapy (itraconazole) was used in all cases once the diagnosis was made, with a median treatment duration of 5 months (interquartile range: 4–6 months). Morbidity included scarring (n = 4, 31{\%}), itraconazole associated diarrhoea (n = 1, 8{\%}) and mild hepatotoxicity (n = 1, 8{\%}). Conclusion: Summarising the clinical experience of these cases is a useful guide for clinical recognition and may serve to shorten the interval between onset and diagnosis, and avoid the need for antibacterial therapy. These data highlight the importance of recognising Sporotrichosis in children outside an outbreak setting, leading to timely diagnosis and appropriate treatment with antifungal agents.",
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    Spotting sporotrichosis skin infection : The first Australian paediatric case series. / Schauer, Anna; Campbell, Anita J.; Arthur, Ian; Blyth, Chris C.; Bowen, Asha C.

    In: Journal of Paediatrics and Child Health, 15.10.2019, p. 1-3.

    Research output: Contribution to journalArticleResearchpeer-review

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    AU - Bowen, Asha C.

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    N2 - Aim: Sporotrichosis is a dermatomycosis caused by the dimorphic fungus, Sporothrix schenckii, with various outbreaks across Australia attributed to mouldy hay. Our objective was to investigate the clinical presentation and management of cutaneous sporotrichosis in a paediatric population of Western Australia. Methods: A retrospective case review was performed for S. schenckii infections in children below 18 years, between January 2000 and November 2017. Cases were identified from the state-wide laboratory database and additional clinical data obtained from medical records. Results: Thirty-two cases of microbiologically proven S. schenckii infection were identified, mostly from rural areas (n = 20, 63%). Complete clinical data were available for 11 cases (34%). The most common risk factors were exposure to farm animals and hay, arthropod bites and outdoor activities. The median duration from symptom onset to correct diagnosis was 6 weeks (interquartile range: 4–7 weeks). Most cases were initially treated with multiple, broad-spectrum antibacterial agents (n = 7, 64%). Targeted therapy (itraconazole) was used in all cases once the diagnosis was made, with a median treatment duration of 5 months (interquartile range: 4–6 months). Morbidity included scarring (n = 4, 31%), itraconazole associated diarrhoea (n = 1, 8%) and mild hepatotoxicity (n = 1, 8%). Conclusion: Summarising the clinical experience of these cases is a useful guide for clinical recognition and may serve to shorten the interval between onset and diagnosis, and avoid the need for antibacterial therapy. These data highlight the importance of recognising Sporotrichosis in children outside an outbreak setting, leading to timely diagnosis and appropriate treatment with antifungal agents.

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