TY - JOUR
T1 - Status of research and development of vaccines for Streptococcus pyogenes
AU - Steer, Andrew C.
AU - Carapetis, Jonathan R.
AU - Dale, James B.
AU - Fraser, John D.
AU - Good, Michael F.
AU - Guilherme, Luiza
AU - Moreland, Nicole J.
AU - Mulholland, Edward Kim
AU - Schodel, Florian
AU - Smeesters, Pierre R.
PY - 2016/6/3
Y1 - 2016/6/3
N2 - Streptococcus pyogenes is an important global pathogen, causing considerable morbidity and mortality, especially in low and middle income countries where rheumatic heart disease and invasive infections are common. There is a number of promising vaccine candidates, most notably those based on the M protein, the key virulence factor for the bacterium. Vaccines against Streptococcus pyogenes are considered as impeded vaccines because of a number of crucial barriers to development. Considerable effort is needed by key players to bring current vaccine candidates through phase III clinical trials and there is a clear need to develop a roadmap for future development of current and new candidates.
AB - Streptococcus pyogenes is an important global pathogen, causing considerable morbidity and mortality, especially in low and middle income countries where rheumatic heart disease and invasive infections are common. There is a number of promising vaccine candidates, most notably those based on the M protein, the key virulence factor for the bacterium. Vaccines against Streptococcus pyogenes are considered as impeded vaccines because of a number of crucial barriers to development. Considerable effort is needed by key players to bring current vaccine candidates through phase III clinical trials and there is a clear need to develop a roadmap for future development of current and new candidates.
KW - Group A Streptococcus
KW - Rheumatic fever
KW - Streptococcus pyogenes
KW - Vaccine
UR - http://www.scopus.com/inward/record.url?scp=84962162202&partnerID=8YFLogxK
U2 - 10.1016/j.vaccine.2016.03.073
DO - 10.1016/j.vaccine.2016.03.073
M3 - Article
AN - SCOPUS:84962162202
VL - 34
SP - 2953
EP - 2958
JO - Vaccine
JF - Vaccine
SN - 0264-410X
IS - 26
ER -