Status of research and development of vaccines for Streptococcus pyogenes

Andrew C. Steer, Jonathan R. Carapetis, James B. Dale, John D. Fraser, Michael F. Good, Luiza Guilherme, Nicole J. Moreland, Edward Kim Mulholland, Florian Schodel, Pierre R. Smeesters

Research output: Contribution to journalArticle

Abstract

Streptococcus pyogenes is an important global pathogen, causing considerable morbidity and mortality, especially in low and middle income countries where rheumatic heart disease and invasive infections are common. There is a number of promising vaccine candidates, most notably those based on the M protein, the key virulence factor for the bacterium. Vaccines against Streptococcus pyogenes are considered as impeded vaccines because of a number of crucial barriers to development. Considerable effort is needed by key players to bring current vaccine candidates through phase III clinical trials and there is a clear need to develop a roadmap for future development of current and new candidates.

Original languageEnglish
Pages (from-to)2953-2958
Number of pages6
JournalVaccine
Volume34
Issue number26
DOIs
Publication statusPublished - 3 Jun 2016
Externally publishedYes

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  • Cite this

    Steer, A. C., Carapetis, J. R., Dale, J. B., Fraser, J. D., Good, M. F., Guilherme, L., Moreland, N. J., Mulholland, E. K., Schodel, F., & Smeesters, P. R. (2016). Status of research and development of vaccines for Streptococcus pyogenes. Vaccine, 34(26), 2953-2958. https://doi.org/10.1016/j.vaccine.2016.03.073