Systematic review and meta-analysis protocol for Fasciola DNA vaccines

Rama Jayaraj, Chellan Kumarasamy, David Piedrafita, Peter Smooker

    Research output: Contribution to journalArticlepeer-review


    Jayaraj R, Kumarasamy C, Piedrafita D, Smooker P., Systematic review and meta-analysis protocol for Fasciola DNA vaccines, Onl J Vet Res., 22 (6):518-525, 2018. We describe a systematic review and meta-analysis of immune response and protective efficacy of Fasciola DNA vaccines following PRISMA-P (2015) guidelines (Moher et al. 2015). Multiple databases of published articles were independently assessed for eligibility and meta-analysis to determine protection rate estimates and pooled odds Ratio with 95% confidence intervals. Heterogeneity was estimated by Higgins I2 statistic and publication bias via funnel plots. A narrative synthesis of systematic review was done where meta-analysis was not possible. Previous studies evaluated effectiveness of DNA encoding Fasciola vaccine candidates, but results are highly variable due to heterogeneity in vaccines and their protocols. We attempt to elucidate this observed heterogeneity for development of DNA vaccines against fascioliasis.
    Original languageEnglish
    Pages (from-to)517-524
    Number of pages8
    JournalOnline Journal of Veterinary Research
    Issue number6
    Publication statusPublished - 2018


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