The 5-HTTLPR polymorphism of the serotonin transporter gene and child's sex moderate the relationship between disaster-related prenatal maternal stress and autism spectrum disorder traits

The QF2011 Queensland flood study

David P. Laplante, Gabrielle Simcock, Lei Cao-Lei, Maya Mouallem, Guillaume Elgbeili, Alain Brunet, Vanessa Cobham, Sue Kildea, Suzanne King

Research output: Contribution to journalArticleResearchpeer-review

Abstract

The 5-HTTLPR polymorphism of the serotonin transporter has been shown to play a role in autism spectrum disorders (ASD). Moreover, disaster-related prenatal maternal stress (PNMS) has also been shown to be associated with ASD. However, no study to date has examined whether these two factors, either individually or in combination, are predictive of ASD traits in the same sample. We hypothesized that children, particularly boys, with the LL genotype exposed to high levels of disaster-related PNMS would exhibit higher levels of ASD traits compared to boys with the LS or SS genotypes and girls regardless of genotype. Genotype and ASD levels obtained using the Australian normed Autism Spectrum Rating Scales - Short Form were available for 105 30-month-old children exposed to varying levels of PNMS following the 2011 Queensland Flood. For boys, higher ASD traits were associated with the 5-HTTLPR LL genotype in combination with either a negative maternal appraisal of the flood, or high levels of maternal composite subjective stress, PSTD-like or peritraumatic dissociation symptoms. For girls, maternal peritraumatic dissociation levels in combination with the 5-HTTLPR LS or SS genotype were associated with higher ASD traits. The present findings are the first to demonstrate that children's genotype moderates effects of disaster-related PNMS on ASD traits, with different pattern according to child sex.

Original languageEnglish
Pages (from-to)1395-1409
Number of pages15
JournalDevelopment and Psychopathology
Volume31
Issue number4
DOIs
Publication statusPublished - Oct 2019
Externally publishedYes

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Serotonin Plasma Membrane Transport Proteins
Queensland
Disasters
Mothers
Genotype
Genes
Dissociative Disorders
Autism Spectrum Disorder
Autistic Disorder

Cite this

Laplante, David P. ; Simcock, Gabrielle ; Cao-Lei, Lei ; Mouallem, Maya ; Elgbeili, Guillaume ; Brunet, Alain ; Cobham, Vanessa ; Kildea, Sue ; King, Suzanne. / The 5-HTTLPR polymorphism of the serotonin transporter gene and child's sex moderate the relationship between disaster-related prenatal maternal stress and autism spectrum disorder traits : The QF2011 Queensland flood study. In: Development and Psychopathology. 2019 ; Vol. 31, No. 4. pp. 1395-1409.
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abstract = "The 5-HTTLPR polymorphism of the serotonin transporter has been shown to play a role in autism spectrum disorders (ASD). Moreover, disaster-related prenatal maternal stress (PNMS) has also been shown to be associated with ASD. However, no study to date has examined whether these two factors, either individually or in combination, are predictive of ASD traits in the same sample. We hypothesized that children, particularly boys, with the LL genotype exposed to high levels of disaster-related PNMS would exhibit higher levels of ASD traits compared to boys with the LS or SS genotypes and girls regardless of genotype. Genotype and ASD levels obtained using the Australian normed Autism Spectrum Rating Scales - Short Form were available for 105 30-month-old children exposed to varying levels of PNMS following the 2011 Queensland Flood. For boys, higher ASD traits were associated with the 5-HTTLPR LL genotype in combination with either a negative maternal appraisal of the flood, or high levels of maternal composite subjective stress, PSTD-like or peritraumatic dissociation symptoms. For girls, maternal peritraumatic dissociation levels in combination with the 5-HTTLPR LS or SS genotype were associated with higher ASD traits. The present findings are the first to demonstrate that children's genotype moderates effects of disaster-related PNMS on ASD traits, with different pattern according to child sex.",
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The 5-HTTLPR polymorphism of the serotonin transporter gene and child's sex moderate the relationship between disaster-related prenatal maternal stress and autism spectrum disorder traits : The QF2011 Queensland flood study. / Laplante, David P.; Simcock, Gabrielle; Cao-Lei, Lei; Mouallem, Maya; Elgbeili, Guillaume; Brunet, Alain; Cobham, Vanessa; Kildea, Sue; King, Suzanne.

In: Development and Psychopathology, Vol. 31, No. 4, 10.2019, p. 1395-1409.

Research output: Contribution to journalArticleResearchpeer-review

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