The burden of Invasive Bacterial Infections in Pemba, Zanibar

Kamala Thriemer, Benedikt Ley, Shaali Ame, Lorenz von Seidlein, Giok de Pak, Na Yoon Chang, Ramadhan Hashim, Wolfgang Hellmut Schmied, Clara Jana Lui BuschClara, Shanette Nixon, Anne Morrissey, Mahesh K. Puri, Mohammad Ali, R. Leon Ochiai, Thomas Wierzba, Mohammad S. Jiddawi, John D. Clemens, Said M. Ali, Jaqueline L. Deen

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    Abstract

    Background: We conducted a surveillance study to determine the leading causes of bloodstream infection in febrile patients seeking treatment at three district hospitals in Pemba Island, Zanzibar, Tanzania, an area with low malaria transmission.

    Methods: All patients above two months of age presenting to hospital with fever were screened, and blood was collected for microbiologic culture and malaria testing. Bacterial sepsis and malaria crude incidence rates were calculated for a one-year period and were adjusted for study participation and diagnostic sensitivity of blood culture.

    Results: Blood culture was performed on 2,209 patients. Among them, 166 (8%) samples yielded bacterial growth; 87 (4%) were considered as likely contaminants; and 79 (4%) as pathogenic bacteria. The most frequent pathogenic bacteria isolated were Salmonella Typhi (n = 46; 58%), followed by Streptococcus pneumoniae (n = 12; 15%). The crude bacteremia rate was 6/100,000 but when adjusted for potentially missed cases the rate may be as high as 163/100,000. Crude and adjusted rates for S. Typhi infections and malaria were 4 and 110/100,000 and 4 and 47/100,000, respectively. Twenty three (51%), 22 (49%) and 22 (49%) of the S.Typhi isolates were found to be resistant toward ampicillin, chloramphenicol and cotrimoxazole, respectively. Multidrug resistance (MDR) against the three antimicrobials was detected in 42% of the isolates.

    Conclusions: In the presence of very low malaria incidence we found high rates of S. Typhi and S. pneumoniae infections on Pemba Island, Zanzibar. Preventive measures such as vaccination could reduce the febrile disease burden.

    Original languageEnglish
    Article numbere30350
    Pages (from-to)1-9
    Number of pages9
    JournalPLoS One
    Volume7
    Issue number2
    DOIs
    Publication statusPublished - 17 Feb 2012

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    Thriemer, K., Ley, B., Ame, S., von Seidlein, L., de Pak, G., Chang, N. Y., Hashim, R., Schmied, W. H., BuschClara, C. J. L., Nixon, S., Morrissey, A., Puri, M. K., Ali, M., Ochiai, R. L., Wierzba, T., Jiddawi, M. S., Clemens, J. D., Ali, S. M., & Deen, J. L. (2012). The burden of Invasive Bacterial Infections in Pemba, Zanibar. PLoS One, 7(2), 1-9. [e30350]. https://doi.org/10.1371/journal.pone.0030350