The changing epidemiology of Plasmodium vivax: Insights from conventional and novel surveillance tools

Sarah Auburn, Qin Cheng, Jutta Marfurt, Ric N. Price

Research output: Contribution to journalReview articlepeer-review

31 Citations (Scopus)
181 Downloads (Pure)

Abstract

Renewed efforts to eliminate malaria have had greater impact on Plasmodium falciparum AU : Pleasenotethatasp than Plasmodium vivax, a reflection of the fundamental differences in the biology of the parasite, its transmission dynamics, and ability to form dormant liver stages. • The main burden of P. vivax malaria is in young children residing in remote communities with poor access to healthcare services. • The decline in P. vivax malaria has led to an increasing proportion of the parasite reservoir occurring in asymptomatic and low-density P. vivax infections and heterogeneous patterns of parasite transmission. • Genetic tools to study the spatial and temporal patterns of P. vivax transmission in different endemicities and ultrasensitive PCR (uPCR)-based techniques are expanding our knowledge of the magnitude and biology of low-density P. vivax infections. • Serology offers alternative ways of detecting recent P. vivax infections and monitoring of the impact of public health interventions at very low endemicity.

Original languageEnglish
Article numbere1003560
JournalPLoS Medicine
Volume18
Issue number4
DOIs
Publication statusPublished - 23 Apr 2021

Bibliographical note

Funding Information:
RNP, SA and JM were supported by the Bill and Melinda Gates Foundation (OPP1054404). RNP is a Wellcome Trust Senior Fellow in Clinical Science (200909). SA also received support from an Australian Research Council Georgina Sweet Award for Women in Quantitative Biomedical Science. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Publisher Copyright:
© 2021 Auburn et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.

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