The changing epidemiology of Plasmodium vivax: Insights from conventional and novel surveillance tools

Sarah Auburn, Qin Cheng, Jutta Marfurt, Ric N. Price

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    Abstract

    Renewed efforts to eliminate malaria have had greater impact on Plasmodium falciparum AU : Pleasenotethatasp than Plasmodium vivax, a reflection of the fundamental differences in the biology of the parasite, its transmission dynamics, and ability to form dormant liver stages. • The main burden of P. vivax malaria is in young children residing in remote communities with poor access to healthcare services. • The decline in P. vivax malaria has led to an increasing proportion of the parasite reservoir occurring in asymptomatic and low-density P. vivax infections and heterogeneous patterns of parasite transmission. • Genetic tools to study the spatial and temporal patterns of P. vivax transmission in different endemicities and ultrasensitive PCR (uPCR)-based techniques are expanding our knowledge of the magnitude and biology of low-density P. vivax infections. • Serology offers alternative ways of detecting recent P. vivax infections and monitoring of the impact of public health interventions at very low endemicity.

    Original languageEnglish
    Article numbere1003560
    JournalPLoS Medicine
    Volume18
    Issue number4
    DOIs
    Publication statusPublished - 23 Apr 2021

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