Abstract
Prior to the introduction of Hemophilus influenzae type b (Hib) conjugate vaccines, Hib was the leading cause of bacterial meningitis in children under five years of age worldwide. In countries that have adopted Hib vaccination schedules, invasive disease has reduced markedly. Oro-naso pharyngeal carriage is recognized as the most significant source of infection. Hib carriage is significantly associated with poverty, such as overcrowding, poor ventilation in houses, lack of running water and high smoking rates. Additionally, many Indigenous minority groups report high rates of Hib carriage. A resurgence of Hib disease among Alaskan children in the 1990s, lead to a change in approach to eliminate Hib disease and carriage in high-risk populations. This new approach identifies strategies for eliminating Hib disease focusing on the reservoirs of colonization within families and communities. Monitoring Hib carriage continues to offer an early warning system, whereby intervention could prevent invasive disease resurgence.
| Original language | English |
|---|---|
| Pages (from-to) | 1254-1260 |
| Number of pages | 7 |
| Journal | Human Vaccines |
| Volume | 7 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - 1 Dec 2011 |
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The continuing role of Hemophilus influenzae type b carriage surveillance as a mechanism for early detection of invasive disease activity. / Jacups, Susan P.
In: Human Vaccines, Vol. 7, No. 12, 01.12.2011, p. 1254-1260.Research output: Contribution to journal › Review article › Research › peer-review
TY - JOUR
T1 - The continuing role of Hemophilus influenzae type b carriage surveillance as a mechanism for early detection of invasive disease activity
AU - Jacups, Susan P.
PY - 2011/12/1
Y1 - 2011/12/1
N2 - Prior to the introduction of Hemophilus influenzae type b (Hib) conjugate vaccines, Hib was the leading cause of bacterial meningitis in children under five years of age worldwide. In countries that have adopted Hib vaccination schedules, invasive disease has reduced markedly. Oro-naso pharyngeal carriage is recognized as the most significant source of infection. Hib carriage is significantly associated with poverty, such as overcrowding, poor ventilation in houses, lack of running water and high smoking rates. Additionally, many Indigenous minority groups report high rates of Hib carriage. A resurgence of Hib disease among Alaskan children in the 1990s, lead to a change in approach to eliminate Hib disease and carriage in high-risk populations. This new approach identifies strategies for eliminating Hib disease focusing on the reservoirs of colonization within families and communities. Monitoring Hib carriage continues to offer an early warning system, whereby intervention could prevent invasive disease resurgence.
AB - Prior to the introduction of Hemophilus influenzae type b (Hib) conjugate vaccines, Hib was the leading cause of bacterial meningitis in children under five years of age worldwide. In countries that have adopted Hib vaccination schedules, invasive disease has reduced markedly. Oro-naso pharyngeal carriage is recognized as the most significant source of infection. Hib carriage is significantly associated with poverty, such as overcrowding, poor ventilation in houses, lack of running water and high smoking rates. Additionally, many Indigenous minority groups report high rates of Hib carriage. A resurgence of Hib disease among Alaskan children in the 1990s, lead to a change in approach to eliminate Hib disease and carriage in high-risk populations. This new approach identifies strategies for eliminating Hib disease focusing on the reservoirs of colonization within families and communities. Monitoring Hib carriage continues to offer an early warning system, whereby intervention could prevent invasive disease resurgence.
KW - Alaskan
KW - Conjugate vaccine
KW - Haemophilus influenzae type b
KW - Hib
KW - Indigenous
KW - Vaccination
UR - http://www.scopus.com/inward/record.url?scp=84855179731&partnerID=8YFLogxK
U2 - 10.4161/hv.7.12.17979
DO - 10.4161/hv.7.12.17979
M3 - Review article
VL - 7
SP - 1254
EP - 1260
JO - Human Vaccines
JF - Human Vaccines
SN - 1554-8600
IS - 12
ER -