The epidemiology of invasive group A streptococcal disease in Victoria, Australia

K O'Grady, L Kelpie, Ross Andrews, Nigel Curtis, T NOLAN, G Selvaraj, J Passmore, F Oppedisano, J Carnie, Jonathan Carapetis

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    Abstract

    Objective: To estimate the incidence and severity of invasive group A streptococcal infection in Victoria, Australia. Design: Prospective active surveillance study. Setting: Public and private laboratories, hospitals and general practitioners throughout Victoria. Patients: People in Victoria diagnosed with group A streptococcal disease notified to the surveillance system between 1 March 2002 and 31 August 2004. Main outcome measure: Confirmed invasive group A streptococcal disease. Results: We identified 333 confirmed cases: an average annualised incidence rate of 2.7 (95% Cl, 2.3-3.2) per 100 000 population per year. Rates were highest in people aged 65 years and older and those younger than 5 years. The case-fatality rate was 7.8%. Streptococcal toxic shock syndrome occurred in 48 patients (14.4%), with a case-fatality rate of 23%. Thirty cases of necrotising fasciitis were reported; five (17%) of these patients died. Type 1 (23%) was the most frequently identified emm sequence type in all age groups. All tested isolates were susceptible to penicillin and clindamycin. Two isolates (4%) were resistant to erythromycin. Conclusion: The incidence of invasive group A streptococcal disease in temperate Australia is greater than previously appreciated and warrants greater public health attention, including its designation as a notifiable disease.
    Original languageEnglish
    Pages (from-to)565-569
    Number of pages5
    JournalMedical Journal of Australia
    Volume186
    Issue number11
    Publication statusPublished - 2007

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    O'Grady, K., Kelpie, L., Andrews, R., Curtis, N., NOLAN, T., Selvaraj, G., Passmore, J., Oppedisano, F., Carnie, J., & Carapetis, J. (2007). The epidemiology of invasive group A streptococcal disease in Victoria, Australia. Medical Journal of Australia, 186(11), 565-569.