The in vitro Antitumour Activity of Substituted Dibutyl-1,3,2-dioxastannolanes

S. C. Ng, Peter G. Parsons, K. Y. Sim, Carolyn J. Tranter, Rodney H. White, David J. Young

Research output: Contribution to journalArticle

Abstract

Six dibutyl-l,3,2-dioxastannolanes, including two enantiomeric pairs, exhibited greater in vitro antitumour activity towards a variety of human tumour cell lines than cisplatin but with little discrimination, suggesting hydrolysis to a common cytotoxic intermediate. A cell line hypersensitive to mitochondrial inhibitors (CI80-13S) was not sensitive to any of the test compounds, suggesting that cell mechanisms other than, or in addition to, mitochondrial function are targeted by tin antitumour agents. A pigmented melanoma cell line (MM418c5) was resistant to the test compounds, which were found to be sequestered by melanin. This resistance was not observed with triphenyltin hydroxide.

Original languageEnglish
Pages (from-to)577-581
Number of pages5
JournalApplied Organometallic Chemistry
Volume11
Issue number7
DOIs
Publication statusPublished - Jul 1997
Externally publishedYes

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