The in vitro Antitumour Activity of Substituted Dibutyl-1,3,2-dioxastannolanes

S. C. Ng; Peter G. Parsons; K. Y. Sim; Carolyn J. Tranter; Rodney H. White; David J. Young

doi:10.1002/(SICI)1099-0739(199707)11:7<577::AID-AOC612>3.0.CO;2-S

The in vitro Antitumour Activity of Substituted Dibutyl-1,3,2-dioxastannolanes

S. C. Ng, Peter G. Parsons, K. Y. Sim, Carolyn J. Tranter, Rodney H. White, David J. Young

Research output: Contribution to journal › Article › peer-review

Abstract

Six dibutyl-l,3,2-dioxastannolanes, including two enantiomeric pairs, exhibited greater in vitro antitumour activity towards a variety of human tumour cell lines than cisplatin but with little discrimination, suggesting hydrolysis to a common cytotoxic intermediate. A cell line hypersensitive to mitochondrial inhibitors (CI80-13S) was not sensitive to any of the test compounds, suggesting that cell mechanisms other than, or in addition to, mitochondrial function are targeted by tin antitumour agents. A pigmented melanoma cell line (MM418c5) was resistant to the test compounds, which were found to be sequestered by melanin. This resistance was not observed with triphenyltin hydroxide.

Original language	English
Pages (from-to)	577-581
Number of pages	5
Journal	Applied Organometallic Chemistry
Volume	11
Issue number	7
DOIs	https://doi.org/10.1002/(SICI)1099-0739(199707)11:7<577::AID-AOC612>3.0.CO;2-S
Publication status	Published - Jul 1997
Externally published	Yes

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title = "The in vitro Antitumour Activity of Substituted Dibutyl-1,3,2-dioxastannolanes",

abstract = "Six dibutyl-l,3,2-dioxastannolanes, including two enantiomeric pairs, exhibited greater in vitro antitumour activity towards a variety of human tumour cell lines than cisplatin but with little discrimination, suggesting hydrolysis to a common cytotoxic intermediate. A cell line hypersensitive to mitochondrial inhibitors (CI80-13S) was not sensitive to any of the test compounds, suggesting that cell mechanisms other than, or in addition to, mitochondrial function are targeted by tin antitumour agents. A pigmented melanoma cell line (MM418c5) was resistant to the test compounds, which were found to be sequestered by melanin. This resistance was not observed with triphenyltin hydroxide.",

keywords = "Antitumour, Dioxastannolanes, Human cell lines",

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AU - Ng, S. C.

AU - Parsons, Peter G.

AU - Sim, K. Y.

AU - Tranter, Carolyn J.

AU - White, Rodney H.

AU - Young, David J.

PY - 1997/7

Y1 - 1997/7

N2 - Six dibutyl-l,3,2-dioxastannolanes, including two enantiomeric pairs, exhibited greater in vitro antitumour activity towards a variety of human tumour cell lines than cisplatin but with little discrimination, suggesting hydrolysis to a common cytotoxic intermediate. A cell line hypersensitive to mitochondrial inhibitors (CI80-13S) was not sensitive to any of the test compounds, suggesting that cell mechanisms other than, or in addition to, mitochondrial function are targeted by tin antitumour agents. A pigmented melanoma cell line (MM418c5) was resistant to the test compounds, which were found to be sequestered by melanin. This resistance was not observed with triphenyltin hydroxide.

AB - Six dibutyl-l,3,2-dioxastannolanes, including two enantiomeric pairs, exhibited greater in vitro antitumour activity towards a variety of human tumour cell lines than cisplatin but with little discrimination, suggesting hydrolysis to a common cytotoxic intermediate. A cell line hypersensitive to mitochondrial inhibitors (CI80-13S) was not sensitive to any of the test compounds, suggesting that cell mechanisms other than, or in addition to, mitochondrial function are targeted by tin antitumour agents. A pigmented melanoma cell line (MM418c5) was resistant to the test compounds, which were found to be sequestered by melanin. This resistance was not observed with triphenyltin hydroxide.

KW - Antitumour

KW - Dioxastannolanes

KW - Human cell lines

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The in vitro Antitumour Activity of Substituted Dibutyl-1,3,2-dioxastannolanes

Abstract

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