The in vitro Antitumour Activity of Substituted Dibutyl-1,3,2-dioxastannolanes

S. C. Ng; Peter G. Parsons; K. Y. Sim; Carolyn J. Tranter; Rodney H. White; David J. Young

doi:10.1002/(SICI)1099-0739(199707)11:7<577::AID-AOC612>3.0.CO;2-S

The in vitro Antitumour Activity of Substituted Dibutyl-1,3,2-dioxastannolanes

S. C. Ng, Peter G. Parsons, K. Y. Sim, Carolyn J. Tranter, Rodney H. White, David J. Young

Research output: Contribution to journal › Article

Abstract

Six dibutyl-l,3,2-dioxastannolanes, including two enantiomeric pairs, exhibited greater in vitro antitumour activity towards a variety of human tumour cell lines than cisplatin but with little discrimination, suggesting hydrolysis to a common cytotoxic intermediate. A cell line hypersensitive to mitochondrial inhibitors (CI80-13S) was not sensitive to any of the test compounds, suggesting that cell mechanisms other than, or in addition to, mitochondrial function are targeted by tin antitumour agents. A pigmented melanoma cell line (MM418c5) was resistant to the test compounds, which were found to be sequestered by melanin. This resistance was not observed with triphenyltin hydroxide.

Original language	English
Pages (from-to)	577-581
Number of pages	5
Journal	Applied Organometallic Chemistry
Volume	11
Issue number	7
DOIs	https://doi.org/10.1002/(SICI)1099-0739(199707)11:7<577::AID-AOC612>3.0.CO;2-S
Publication status	Published - Jul 1997
Externally published	Yes

Access to Document

10.1002/(SICI)1099-0739(199707)11:7<577::AID-AOC612>3.0.CO;2-S

Link to publication in Scopus

Fingerprint Dive into the research topics of 'The in vitro Antitumour Activity of Substituted Dibutyl-1,3,2-dioxastannolanes'. Together they form a unique fingerprint.

Cite this

@article{aca0d1c9b7c14a9aa2bf45c67312fc18,

title = "The in vitro Antitumour Activity of Substituted Dibutyl-1,3,2-dioxastannolanes",

abstract = "Six dibutyl-l,3,2-dioxastannolanes, including two enantiomeric pairs, exhibited greater in vitro antitumour activity towards a variety of human tumour cell lines than cisplatin but with little discrimination, suggesting hydrolysis to a common cytotoxic intermediate. A cell line hypersensitive to mitochondrial inhibitors (CI80-13S) was not sensitive to any of the test compounds, suggesting that cell mechanisms other than, or in addition to, mitochondrial function are targeted by tin antitumour agents. A pigmented melanoma cell line (MM418c5) was resistant to the test compounds, which were found to be sequestered by melanin. This resistance was not observed with triphenyltin hydroxide.",

keywords = "Antitumour, Dioxastannolanes, Human cell lines",

author = "Ng, {S. C.} and Parsons, {Peter G.} and Sim, {K. Y.} and Tranter, {Carolyn J.} and White, {Rodney H.} and Young, {David J.}",

year = "1997",

month = jul

doi = "10.1002/(SICI)1099-0739(199707)11:7<577::AID-AOC612>3.0.CO;2-S",

language = "English",

volume = "11",

pages = "577--581",

journal = "Applied Organometallic Chemistry",

issn = "0268-2605",

publisher = "John Wiley & Sons",

number = "7",

}

TY - JOUR

T1 - The in vitro Antitumour Activity of Substituted Dibutyl-1,3,2-dioxastannolanes

AU - Ng, S. C.

AU - Parsons, Peter G.

AU - Sim, K. Y.

AU - Tranter, Carolyn J.

AU - White, Rodney H.

AU - Young, David J.

PY - 1997/7

Y1 - 1997/7

N2 - Six dibutyl-l,3,2-dioxastannolanes, including two enantiomeric pairs, exhibited greater in vitro antitumour activity towards a variety of human tumour cell lines than cisplatin but with little discrimination, suggesting hydrolysis to a common cytotoxic intermediate. A cell line hypersensitive to mitochondrial inhibitors (CI80-13S) was not sensitive to any of the test compounds, suggesting that cell mechanisms other than, or in addition to, mitochondrial function are targeted by tin antitumour agents. A pigmented melanoma cell line (MM418c5) was resistant to the test compounds, which were found to be sequestered by melanin. This resistance was not observed with triphenyltin hydroxide.

AB - Six dibutyl-l,3,2-dioxastannolanes, including two enantiomeric pairs, exhibited greater in vitro antitumour activity towards a variety of human tumour cell lines than cisplatin but with little discrimination, suggesting hydrolysis to a common cytotoxic intermediate. A cell line hypersensitive to mitochondrial inhibitors (CI80-13S) was not sensitive to any of the test compounds, suggesting that cell mechanisms other than, or in addition to, mitochondrial function are targeted by tin antitumour agents. A pigmented melanoma cell line (MM418c5) was resistant to the test compounds, which were found to be sequestered by melanin. This resistance was not observed with triphenyltin hydroxide.

KW - Antitumour

KW - Dioxastannolanes

KW - Human cell lines

UR - http://www.scopus.com/inward/record.url?scp=0000991171&partnerID=8YFLogxK

U2 - 10.1002/(SICI)1099-0739(199707)11:7<577::AID-AOC612>3.0.CO;2-S

DO - 10.1002/(SICI)1099-0739(199707)11:7<577::AID-AOC612>3.0.CO;2-S

M3 - Article

AN - SCOPUS:0000991171

VL - 11

SP - 577

EP - 581

JO - Applied Organometallic Chemistry

JF - Applied Organometallic Chemistry

SN - 0268-2605

IS - 7

ER -