Abstract
Six dibutyl-l,3,2-dioxastannolanes, including two enantiomeric pairs, exhibited greater in vitro antitumour activity towards a variety of human tumour cell lines than cisplatin but with little discrimination, suggesting hydrolysis to a common cytotoxic intermediate. A cell line hypersensitive to mitochondrial inhibitors (CI80-13S) was not sensitive to any of the test compounds, suggesting that cell mechanisms other than, or in addition to, mitochondrial function are targeted by tin antitumour agents. A pigmented melanoma cell line (MM418c5) was resistant to the test compounds, which were found to be sequestered by melanin. This resistance was not observed with triphenyltin hydroxide.
Original language | English |
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Pages (from-to) | 577-581 |
Number of pages | 5 |
Journal | Applied Organometallic Chemistry |
Volume | 11 |
Issue number | 7 |
DOIs | |
Publication status | Published - Jul 1997 |
Externally published | Yes |