The in vitro cytotoxicity and DNA alkylating ability of the simplest functional analogues of the seco CC-1065 alkylating subunit

Rodney H. White; Peter G. Parsons; Arungundrum S. Prakash; David J. Young

doi:10.1016/0960-894X(95)00310-P

The in vitro cytotoxicity and DNA alkylating ability of the simplest functional analogues of the seco CC-1065 alkylating subunit

Rodney H. White, Peter G. Parsons, Arungundrum S. Prakash, David J. Young

Research output: Contribution to journal › Article › peer-review

Abstract

The p-hydroxyphenethyl halides 1(b-d) possess the minimum structural requirements for alkylating DNA with Ar-3′ participation and exhibit in vitro cytotoxicity and DNA alkylating ability/sequence selectivity which is diminished relative to more functionalised seco analogues of the antitumor agent CC-1065 alkylating subunit.

Original language	English
Pages (from-to)	1869-1874
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	5
Issue number	16
DOIs	https://doi.org/10.1016/0960-894X(95)00310-P
Publication status	Published - 17 Aug 1995
Externally published	Yes

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title = "The in vitro cytotoxicity and DNA alkylating ability of the simplest functional analogues of the seco CC-1065 alkylating subunit",

abstract = "The p-hydroxyphenethyl halides 1(b-d) possess the minimum structural requirements for alkylating DNA with Ar-3′ participation and exhibit in vitro cytotoxicity and DNA alkylating ability/sequence selectivity which is diminished relative to more functionalised seco analogues of the antitumor agent CC-1065 alkylating subunit.",

author = "White, {Rodney H.} and Parsons, {Peter G.} and Prakash, {Arungundrum S.} and Young, {David J.}",

year = "1995",

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AU - White, Rodney H.

AU - Parsons, Peter G.

AU - Prakash, Arungundrum S.

AU - Young, David J.

PY - 1995/8/17

Y1 - 1995/8/17

N2 - The p-hydroxyphenethyl halides 1(b-d) possess the minimum structural requirements for alkylating DNA with Ar-3′ participation and exhibit in vitro cytotoxicity and DNA alkylating ability/sequence selectivity which is diminished relative to more functionalised seco analogues of the antitumor agent CC-1065 alkylating subunit.

AB - The p-hydroxyphenethyl halides 1(b-d) possess the minimum structural requirements for alkylating DNA with Ar-3′ participation and exhibit in vitro cytotoxicity and DNA alkylating ability/sequence selectivity which is diminished relative to more functionalised seco analogues of the antitumor agent CC-1065 alkylating subunit.

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U2 - 10.1016/0960-894X(95)00310-P

DO - 10.1016/0960-894X(95)00310-P

M3 - Article

AN - SCOPUS:0029094625

VL - 5

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EP - 1874

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

IS - 16

ER -

The in vitro cytotoxicity and DNA alkylating ability of the simplest functional analogues of the seco CC-1065 alkylating subunit

Abstract

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