Abstract
The p-hydroxyphenethyl halides 1(b-d) possess the minimum structural requirements for alkylating DNA with Ar-3′ participation and exhibit in vitro cytotoxicity and DNA alkylating ability/sequence selectivity which is diminished relative to more functionalised seco analogues of the antitumor agent CC-1065 alkylating subunit.
Original language | English |
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Pages (from-to) | 1869-1874 |
Number of pages | 6 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 5 |
Issue number | 16 |
DOIs | |
Publication status | Published - 17 Aug 1995 |
Externally published | Yes |