The in vitro cytotoxicity and DNA alkylating ability of the simplest functional analogues of the seco CC-1065 alkylating subunit

Rodney H. White, Peter G. Parsons, Arungundrum S. Prakash, David J. Young

Research output: Contribution to journalArticle

Abstract

The p-hydroxyphenethyl halides 1(b-d) possess the minimum structural requirements for alkylating DNA with Ar-3′ participation and exhibit in vitro cytotoxicity and DNA alkylating ability/sequence selectivity which is diminished relative to more functionalised seco analogues of the antitumor agent CC-1065 alkylating subunit.

Original languageEnglish
Pages (from-to)1869-1874
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume5
Issue number16
DOIs
Publication statusPublished - 17 Aug 1995
Externally publishedYes

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