The in vitro cytotoxicity and DNA alkylating ability of the simplest functional analogues of the seco CC-1065 alkylating subunit

Rodney H. White, Peter G. Parsons, Arungundrum S. Prakash, David J. Young

Research output: Contribution to journal › Article › Research › peer-review

Abstract

The p-hydroxyphenethyl halides 1(b-d) possess the minimum structural requirements for alkylating DNA with Ar-3′ participation and exhibit in vitro cytotoxicity and DNA alkylating ability/sequence selectivity which is diminished relative to more functionalised seco analogues of the antitumor agent CC-1065 alkylating subunit.

Original languageEnglish
Pages (from-to)1869-1874
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume5
Issue number16
DOIs
Publication statusPublished - 17 Aug 1995
Externally publishedYes

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CC 1065
Cytotoxicity
DNA
Antineoplastic Agents
In Vitro Techniques

Cite this

White, Rodney H. ; Parsons, Peter G. ; Prakash, Arungundrum S. ; Young, David J. / The in vitro cytotoxicity and DNA alkylating ability of the simplest functional analogues of the seco CC-1065 alkylating subunit. In: Bioorganic and Medicinal Chemistry Letters. 1995 ; Vol. 5, No. 16. pp. 1869-1874.
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abstract = "The p-hydroxyphenethyl halides 1(b-d) possess the minimum structural requirements for alkylating DNA with Ar-3′ participation and exhibit in vitro cytotoxicity and DNA alkylating ability/sequence selectivity which is diminished relative to more functionalised seco analogues of the antitumor agent CC-1065 alkylating subunit.",
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White, RH, Parsons, PG, Prakash, AS & Young, DJ 1995, 'The in vitro cytotoxicity and DNA alkylating ability of the simplest functional analogues of the seco CC-1065 alkylating subunit', Bioorganic and Medicinal Chemistry Letters, vol. 5, no. 16, pp. 1869-1874. https://doi.org/10.1016/0960-894X(95)00310-P

The in vitro cytotoxicity and DNA alkylating ability of the simplest functional analogues of the seco CC-1065 alkylating subunit. / White, Rodney H.; Parsons, Peter G.; Prakash, Arungundrum S.; Young, David J.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 5, No. 16, 17.08.1995, p. 1869-1874.

Research output: Contribution to journal › Article › Research › peer-review

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T1 - The in vitro cytotoxicity and DNA alkylating ability of the simplest functional analogues of the seco CC-1065 alkylating subunit

AU - White, Rodney H.

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AU - Young, David J.

PY - 1995/8/17

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AB - The p-hydroxyphenethyl halides 1(b-d) possess the minimum structural requirements for alkylating DNA with Ar-3′ participation and exhibit in vitro cytotoxicity and DNA alkylating ability/sequence selectivity which is diminished relative to more functionalised seco analogues of the antitumor agent CC-1065 alkylating subunit.

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JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

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White RH, Parsons PG, Prakash AS, Young DJ. The in vitro cytotoxicity and DNA alkylating ability of the simplest functional analogues of the seco CC-1065 alkylating subunit. Bioorganic and Medicinal Chemistry Letters. 1995 Aug 17;5(16):1869-1874. https://doi.org/10.1016/0960-894X(95)00310-P

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