The in vitro cytotoxicity and DNA alkylating ability of the simplest functional analogues of the seco CC-1065 alkylating subunit

Rodney H. White; Peter G. Parsons; Arungundrum S. Prakash; David J. Young

doi:10.1016/0960-894X(95)00310-P

The in vitro cytotoxicity and DNA alkylating ability of the simplest functional analogues of the seco CC-1065 alkylating subunit

Rodney H. White, Peter G. Parsons, Arungundrum S. Prakash, David J. Young

Research output: Contribution to journal › Article

Abstract

The p-hydroxyphenethyl halides 1(b-d) possess the minimum structural requirements for alkylating DNA with Ar-3′ participation and exhibit in vitro cytotoxicity and DNA alkylating ability/sequence selectivity which is diminished relative to more functionalised seco analogues of the antitumor agent CC-1065 alkylating subunit.

Original language	English
Pages (from-to)	1869-1874
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	5
Issue number	16
DOIs	https://doi.org/10.1016/0960-894X(95)00310-P
Publication status	Published - 17 Aug 1995
Externally published	Yes

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10.1016/0960-894X(95)00310-P

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White, R. H., Parsons, P. G., Prakash, A. S., & Young, D. J. (1995). The in vitro cytotoxicity and DNA alkylating ability of the simplest functional analogues of the seco CC-1065 alkylating subunit. Bioorganic and Medicinal Chemistry Letters, 5(16), 1869-1874. https://doi.org/10.1016/0960-894X(95)00310-P

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