The role of Kingella kingae in pre-school aged children with bone and joint infections

Laudi Olijve; Lahiru Amarasena; Emma Best; Christopher Blyth; Mirjam van den Boom; Asha Bowen; Penelope A. Bryant; Jim Buttery; Hazel C. Dobinson; Joshua Davis; Joshua Francis; Heidi Goldsmith; Elle Griffiths; Te Yu Hung; Julie Huynh; Alison Kesson; Andrea Meehan; Brendan McMullan; Clare Nourse; Pamela Palasanthiran; Rushi Penumarthy; Katie Pilkington; Janine Searle; Anya Stephenson; Rachel Webb; Jonathan Williman; Tony Walls

doi:10.1016/j.jinf.2021.06.028

The role of Kingella kingae in pre-school aged children with bone and joint infections

Laudi Olijve, Lahiru Amarasena, Emma Best, Christopher Blyth, Mirjam van den Boom, Asha Bowen, Penelope A. Bryant, Jim Buttery, Hazel C. Dobinson, Joshua Davis, Joshua Francis, Heidi Goldsmith, Elle Griffiths, Te Yu Hung, Julie Huynh, Alison Kesson, Andrea Meehan, Brendan McMullan, Clare Nourse, Pamela PalasanthiranRushi Penumarthy, Katie Pilkington, Janine Searle, Anya Stephenson, Rachel Webb, Jonathan Williman, Tony Walls

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Objectives: The Pre-school Osteoarticular Infection (POI) study aimed to describe the burden of disease, epidemiology, microbiology and treatment of acute osteoarticular infections (OAI) and the role of Kingella kingae in these infections.

Methods: Information about children 3–60 months of age who were hospitalized with an OAI to 11 different hospitals across Australia and New Zealand between January 2012 and December 2016 was collected retrospectively.

Results: A total of 907 cases (73%) were included. Blood cultures grew a likely pathogen in only 18% (140/781). The peak age of presentation was 12 to 24 months (466/907, 51%) and Kingella kingae was the most frequently detected microorganism in this age group (60/466, 13%). In the majority of cases, no microorganism was detected (517/907, 57%). Addition of PCR to culture increased detection rates of K. kingae. However, PCR was performed infrequently (63/907, 7%).

Conclusions: This large multi-national study highlights the need for more widespread use of molecular diagnostic techniques for accurate microbiological diagnosis of OAI in pre-school aged children. The data from this study supports the hypothesis that a substantial proportion of pre-school aged children with OAI and no organism identified may in fact have undiagnosed K. kingae infection. Improved detection of Kingella cases is likely to reduce the average length of antimicrobial treatment.

Original language	English
Pages (from-to)	321-331
Number of pages	11
Journal	Journal of Infection
Volume	83
Issue number	3
Early online date	28 Jun 2021
DOIs	https://doi.org/10.1016/j.jinf.2021.06.028
Publication status	Published - Sept 2021

Bibliographical note

Funding Information:
AB receives Investigator Award funding from the National Health and Medical Research Council ( 1175509 ). CCB receives Investigator Award funding from the National Health and Medical Research Council ( 1173163 ). PAB is in receipt of a Murdoch Children's Research Institute Clinician Scientist Fellowship, and a National Health and Medical Research Council Investigator Grant. JSD receives salary funding from Australia's National Health and Medical Research Council (Fellowship number 1160331 ). BM is funded by a PhD scholarship from the University of Melbourne. JRF Receives funding from Department of Foreign Affairs and Trade, Indo-Pacific centre for Health Security and UK Aid Fleming Fund.

Publisher Copyright:
© 2021

Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.

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10.1016/j.jinf.2021.06.028

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Olijve, L., Amarasena, L., Best, E., Blyth, C., van den Boom, M., Bowen, A., Bryant, P. A., Buttery, J., Dobinson, H. C., Davis, J., Francis, J., Goldsmith, H., Griffiths, E., Hung, T. Y., Huynh, J., Kesson, A., Meehan, A., McMullan, B., Nourse, C., ... Walls, T. (2021). The role of Kingella kingae in pre-school aged children with bone and joint infections. Journal of Infection, 83(3), 321-331. https://doi.org/10.1016/j.jinf.2021.06.028

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title = "The role of Kingella kingae in pre-school aged children with bone and joint infections",

abstract = "Objectives: The Pre-school Osteoarticular Infection (POI) study aimed to describe the burden of disease, epidemiology, microbiology and treatment of acute osteoarticular infections (OAI) and the role of Kingella kingae in these infections. Methods: Information about children 3–60 months of age who were hospitalized with an OAI to 11 different hospitals across Australia and New Zealand between January 2012 and December 2016 was collected retrospectively. Results: A total of 907 cases (73%) were included. Blood cultures grew a likely pathogen in only 18% (140/781). The peak age of presentation was 12 to 24 months (466/907, 51%) and Kingella kingae was the most frequently detected microorganism in this age group (60/466, 13%). In the majority of cases, no microorganism was detected (517/907, 57%). Addition of PCR to culture increased detection rates of K. kingae. However, PCR was performed infrequently (63/907, 7%). Conclusions: This large multi-national study highlights the need for more widespread use of molecular diagnostic techniques for accurate microbiological diagnosis of OAI in pre-school aged children. The data from this study supports the hypothesis that a substantial proportion of pre-school aged children with OAI and no organism identified may in fact have undiagnosed K. kingae infection. Improved detection of Kingella cases is likely to reduce the average length of antimicrobial treatment.",

keywords = "Child, Infections, Kingella kingae, Osteomyelitis, Septic arthritis",

author = "Laudi Olijve and Lahiru Amarasena and Emma Best and Christopher Blyth and {van den Boom}, Mirjam and Asha Bowen and Bryant, {Penelope A.} and Jim Buttery and Dobinson, {Hazel C.} and Joshua Davis and Joshua Francis and Heidi Goldsmith and Elle Griffiths and Hung, {Te Yu} and Julie Huynh and Alison Kesson and Andrea Meehan and Brendan McMullan and Clare Nourse and Pamela Palasanthiran and Rushi Penumarthy and Katie Pilkington and Janine Searle and Anya Stephenson and Rachel Webb and Jonathan Williman and Tony Walls",

note = "Funding Information: AB receives Investigator Award funding from the National Health and Medical Research Council ( 1175509 ). CCB receives Investigator Award funding from the National Health and Medical Research Council ( 1173163 ). PAB is in receipt of a Murdoch Children's Research Institute Clinician Scientist Fellowship, and a National Health and Medical Research Council Investigator Grant. JSD receives salary funding from Australia's National Health and Medical Research Council (Fellowship number 1160331 ). BM is funded by a PhD scholarship from the University of Melbourne. JRF Receives funding from Department of Foreign Affairs and Trade, Indo-Pacific centre for Health Security and UK Aid Fleming Fund. Publisher Copyright: {\textcopyright} 2021 Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",

year = "2021",

month = sep,

doi = "10.1016/j.jinf.2021.06.028",

language = "English",

volume = "83",

pages = "321--331",

journal = "Journal of Infection",

issn = "0163-4453",

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Olijve, L, Amarasena, L, Best, E, Blyth, C, van den Boom, M, Bowen, A, Bryant, PA, Buttery, J, Dobinson, HC, Davis, J, Francis, J, Goldsmith, H, Griffiths, E, Hung, TY, Huynh, J, Kesson, A, Meehan, A, McMullan, B, Nourse, C, Palasanthiran, P, Penumarthy, R, Pilkington, K, Searle, J, Stephenson, A, Webb, R, Williman, J & Walls, T 2021, 'The role of Kingella kingae in pre-school aged children with bone and joint infections', Journal of Infection, vol. 83, no. 3, pp. 321-331. https://doi.org/10.1016/j.jinf.2021.06.028

TY - JOUR

T1 - The role of Kingella kingae in pre-school aged children with bone and joint infections

AU - Olijve, Laudi

AU - Amarasena, Lahiru

AU - Best, Emma

AU - Blyth, Christopher

AU - van den Boom, Mirjam

AU - Bowen, Asha

AU - Bryant, Penelope A.

AU - Buttery, Jim

AU - Dobinson, Hazel C.

AU - Davis, Joshua

AU - Francis, Joshua

AU - Goldsmith, Heidi

AU - Griffiths, Elle

AU - Hung, Te Yu

AU - Huynh, Julie

AU - Kesson, Alison

AU - Meehan, Andrea

AU - McMullan, Brendan

AU - Nourse, Clare

AU - Palasanthiran, Pamela

AU - Penumarthy, Rushi

AU - Pilkington, Katie

AU - Searle, Janine

AU - Stephenson, Anya

AU - Webb, Rachel

AU - Williman, Jonathan

AU - Walls, Tony

N1 - Funding Information: AB receives Investigator Award funding from the National Health and Medical Research Council ( 1175509 ). CCB receives Investigator Award funding from the National Health and Medical Research Council ( 1173163 ). PAB is in receipt of a Murdoch Children's Research Institute Clinician Scientist Fellowship, and a National Health and Medical Research Council Investigator Grant. JSD receives salary funding from Australia's National Health and Medical Research Council (Fellowship number 1160331 ). BM is funded by a PhD scholarship from the University of Melbourne. JRF Receives funding from Department of Foreign Affairs and Trade, Indo-Pacific centre for Health Security and UK Aid Fleming Fund. Publisher Copyright: © 2021 Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/9

Y1 - 2021/9

N2 - Objectives: The Pre-school Osteoarticular Infection (POI) study aimed to describe the burden of disease, epidemiology, microbiology and treatment of acute osteoarticular infections (OAI) and the role of Kingella kingae in these infections. Methods: Information about children 3–60 months of age who were hospitalized with an OAI to 11 different hospitals across Australia and New Zealand between January 2012 and December 2016 was collected retrospectively. Results: A total of 907 cases (73%) were included. Blood cultures grew a likely pathogen in only 18% (140/781). The peak age of presentation was 12 to 24 months (466/907, 51%) and Kingella kingae was the most frequently detected microorganism in this age group (60/466, 13%). In the majority of cases, no microorganism was detected (517/907, 57%). Addition of PCR to culture increased detection rates of K. kingae. However, PCR was performed infrequently (63/907, 7%). Conclusions: This large multi-national study highlights the need for more widespread use of molecular diagnostic techniques for accurate microbiological diagnosis of OAI in pre-school aged children. The data from this study supports the hypothesis that a substantial proportion of pre-school aged children with OAI and no organism identified may in fact have undiagnosed K. kingae infection. Improved detection of Kingella cases is likely to reduce the average length of antimicrobial treatment.

AB - Objectives: The Pre-school Osteoarticular Infection (POI) study aimed to describe the burden of disease, epidemiology, microbiology and treatment of acute osteoarticular infections (OAI) and the role of Kingella kingae in these infections. Methods: Information about children 3–60 months of age who were hospitalized with an OAI to 11 different hospitals across Australia and New Zealand between January 2012 and December 2016 was collected retrospectively. Results: A total of 907 cases (73%) were included. Blood cultures grew a likely pathogen in only 18% (140/781). The peak age of presentation was 12 to 24 months (466/907, 51%) and Kingella kingae was the most frequently detected microorganism in this age group (60/466, 13%). In the majority of cases, no microorganism was detected (517/907, 57%). Addition of PCR to culture increased detection rates of K. kingae. However, PCR was performed infrequently (63/907, 7%). Conclusions: This large multi-national study highlights the need for more widespread use of molecular diagnostic techniques for accurate microbiological diagnosis of OAI in pre-school aged children. The data from this study supports the hypothesis that a substantial proportion of pre-school aged children with OAI and no organism identified may in fact have undiagnosed K. kingae infection. Improved detection of Kingella cases is likely to reduce the average length of antimicrobial treatment.

KW - Child

KW - Infections

KW - Kingella kingae

KW - Osteomyelitis

KW - Septic arthritis

UR - http://www.scopus.com/inward/record.url?scp=85111855430&partnerID=8YFLogxK

U2 - 10.1016/j.jinf.2021.06.028

DO - 10.1016/j.jinf.2021.06.028

M3 - Article

C2 - 34265316

AN - SCOPUS:85111855430

SN - 0163-4453

VL - 83

SP - 321

EP - 331

JO - Journal of Infection

JF - Journal of Infection

IS - 3

ER -

The role of Kingella kingae in pre-school aged children with bone and joint infections

Abstract

Bibliographical note

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