Indonesia is a disaster-prone region facing multiple hazards. The impact has cost human casualties, injuries, damages to assets, environment and regional development. In order to protect the people and assets, the government has increased the capacity to face and anticipate disaster which is through a multi-hazard early warning system (MHEWS). The academic sector in Indonesia, especially prominent universities such as Institut Teknologi Bandung and Universitas Gajah Mada has contributed positively to the development of MHEWS and the Land Slide Early Warning System. This research aims to examine the role of universities in Indonesia related to the establishment of an MHEWS in Indonesia by answering what are the roles and the challenges. The research methodology is through a desk study and document review of government and organizations reports using qualitative and descriptive analysis. The findings of the research indicate the role of universities in the MHEWS is in line with the concept of tri dharma of universities which research, higher education and outreach. This means the role of universities to conduct research related to early warning systems, higher education through having program studies related to disaster management and outreach the role to train the community, organizations, and government through professional networks. Unfortunately, the involvement of the eastern part of Indonesian universities still needs to increase capacity, awareness, and access in utilizing the MHEWS at the local level.