The suprachoroidal pathway: A new drug delivery route to the back of the eye

Uma Do J.P. Rai, Simon A. Young, Thilini R. Thrimawithana, Hamdy Abdelkader, Adam W.G. Alani, Barbara Pierscionek, Raid G. Alany

Research output: Contribution to journalReview articlepeer-review


The development of safe and convenient drug delivery strategies for treatment of posterior segment eye diseases is challenging. Although intravitreal injection has wide acceptance amongst clinicians, its use is associated with serious side-effects. Recently, the suprachoroidal space (SCS) has attracted the attention of ophthalmologists and pharmaceutical formulators as a potential site for drug administration and delivery to the posterior segment of the eye. This review highlights the major constraints of drug delivery to the posterior eye segment, key anatomical and physiological features of the SCS and drug delivery applications of this route with emphasis on microneedles along with future perspectives.

Original languageEnglish
Pages (from-to)491-495
Number of pages5
JournalDrug Discovery Today
Issue number4
Publication statusPublished - 1 Apr 2015
Externally publishedYes


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