The Treatment of Plasmodium knowlesi Malaria

Research output: Contribution to journalReview articleResearchpeer-review

Abstract

Plasmodium knowlesi occurs across Southeast Asia and is the most common cause of malaria in Malaysia. High parasitaemias can develop rapidly, and the risk of severe disease in adults is at least as high as in falciparum malaria. Prompt initiation of effective treatment is therefore essential. Intravenous artesunate is highly effective in severe knowlesi malaria and in those with moderately high parasitaemia but otherwise uncomplicated disease. Both chloroquine and artemisinin-combination therapy (ACT) are highly effective for uncomplicated knowlesi malaria, with faster parasite clearance times and lower anaemia rates with ACT. Given the difficulties with microscope diagnosis of P. knowlesi, a unified treatment strategy of ACT for all Plasmodium species is recommended in coendemic regions.

Original languageEnglish
Pages (from-to)242-253
Number of pages12
JournalTrends in Parasitology
Volume33
Issue number3
Early online date1 Oct 2016
DOIs
Publication statusPublished - Mar 2017

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Plasmodium knowlesi
Plasmodium malariae
Malaria
Parasitemia
Southeastern Asia
Plasmodium
Falciparum Malaria
Malaysia
Chloroquine
Anemia
Parasites
Therapeutics
artemisinine

Cite this

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title = "The Treatment of Plasmodium knowlesi Malaria",
abstract = "Plasmodium knowlesi occurs across Southeast Asia and is the most common cause of malaria in Malaysia. High parasitaemias can develop rapidly, and the risk of severe disease in adults is at least as high as in falciparum malaria. Prompt initiation of effective treatment is therefore essential. Intravenous artesunate is highly effective in severe knowlesi malaria and in those with moderately high parasitaemia but otherwise uncomplicated disease. Both chloroquine and artemisinin-combination therapy (ACT) are highly effective for uncomplicated knowlesi malaria, with faster parasite clearance times and lower anaemia rates with ACT. Given the difficulties with microscope diagnosis of P. knowlesi, a unified treatment strategy of ACT for all Plasmodium species is recommended in coendemic regions.",
keywords = "Artemisinin-combination therapy, Malaria, Plasmodium knowlesi, Treatment",
author = "Barber, {Bridget E.} and Grigg, {Matthew J.} and Timothy William and Yeo, {Tsin W.} and Anstey, {Nicholas M.}",
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The Treatment of Plasmodium knowlesi Malaria. / Barber, Bridget E.; Grigg, Matthew J.; William, Timothy; Yeo, Tsin W.; Anstey, Nicholas M.

In: Trends in Parasitology, Vol. 33, No. 3, 03.2017, p. 242-253.

Research output: Contribution to journalReview articleResearchpeer-review

TY - JOUR

T1 - The Treatment of Plasmodium knowlesi Malaria

AU - Barber, Bridget E.

AU - Grigg, Matthew J.

AU - William, Timothy

AU - Yeo, Tsin W.

AU - Anstey, Nicholas M.

PY - 2017/3

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AB - Plasmodium knowlesi occurs across Southeast Asia and is the most common cause of malaria in Malaysia. High parasitaemias can develop rapidly, and the risk of severe disease in adults is at least as high as in falciparum malaria. Prompt initiation of effective treatment is therefore essential. Intravenous artesunate is highly effective in severe knowlesi malaria and in those with moderately high parasitaemia but otherwise uncomplicated disease. Both chloroquine and artemisinin-combination therapy (ACT) are highly effective for uncomplicated knowlesi malaria, with faster parasite clearance times and lower anaemia rates with ACT. Given the difficulties with microscope diagnosis of P. knowlesi, a unified treatment strategy of ACT for all Plasmodium species is recommended in coendemic regions.

KW - Artemisinin-combination therapy

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KW - Plasmodium knowlesi

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