The Treatment of Plasmodium knowlesi Malaria

Bridget E. Barber, Matthew J. Grigg, Timothy William, Tsin W. Yeo, Nicholas M. Anstey

    Research output: Contribution to journalReview articleResearchpeer-review

    Abstract

    Plasmodium knowlesi occurs across Southeast Asia and is the most common cause of malaria in Malaysia. High parasitaemias can develop rapidly, and the risk of severe disease in adults is at least as high as in falciparum malaria. Prompt initiation of effective treatment is therefore essential. Intravenous artesunate is highly effective in severe knowlesi malaria and in those with moderately high parasitaemia but otherwise uncomplicated disease. Both chloroquine and artemisinin-combination therapy (ACT) are highly effective for uncomplicated knowlesi malaria, with faster parasite clearance times and lower anaemia rates with ACT. Given the difficulties with microscope diagnosis of P. knowlesi, a unified treatment strategy of ACT for all Plasmodium species is recommended in coendemic regions.

    Original languageEnglish
    Pages (from-to)242-253
    Number of pages12
    JournalTrends in Parasitology
    Volume33
    Issue number3
    Early online date1 Oct 2016
    DOIs
    Publication statusPublished - Mar 2017

    Fingerprint

    Plasmodium knowlesi
    Plasmodium malariae
    Malaria
    Parasitemia
    Southeastern Asia
    Plasmodium
    Falciparum Malaria
    Malaysia
    Chloroquine
    Anemia
    Parasites
    Therapeutics
    artemisinine

    Cite this

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    title = "The Treatment of Plasmodium knowlesi Malaria",
    abstract = "Plasmodium knowlesi occurs across Southeast Asia and is the most common cause of malaria in Malaysia. High parasitaemias can develop rapidly, and the risk of severe disease in adults is at least as high as in falciparum malaria. Prompt initiation of effective treatment is therefore essential. Intravenous artesunate is highly effective in severe knowlesi malaria and in those with moderately high parasitaemia but otherwise uncomplicated disease. Both chloroquine and artemisinin-combination therapy (ACT) are highly effective for uncomplicated knowlesi malaria, with faster parasite clearance times and lower anaemia rates with ACT. Given the difficulties with microscope diagnosis of P. knowlesi, a unified treatment strategy of ACT for all Plasmodium species is recommended in coendemic regions.",
    keywords = "Artemisinin-combination therapy, Malaria, Plasmodium knowlesi, Treatment",
    author = "Barber, {Bridget E.} and Grigg, {Matthew J.} and Timothy William and Yeo, {Tsin W.} and Anstey, {Nicholas M.}",
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    The Treatment of Plasmodium knowlesi Malaria. / Barber, Bridget E.; Grigg, Matthew J.; William, Timothy; Yeo, Tsin W.; Anstey, Nicholas M.

    In: Trends in Parasitology, Vol. 33, No. 3, 03.2017, p. 242-253.

    Research output: Contribution to journalReview articleResearchpeer-review

    TY - JOUR

    T1 - The Treatment of Plasmodium knowlesi Malaria

    AU - Barber, Bridget E.

    AU - Grigg, Matthew J.

    AU - William, Timothy

    AU - Yeo, Tsin W.

    AU - Anstey, Nicholas M.

    PY - 2017/3

    Y1 - 2017/3

    N2 - Plasmodium knowlesi occurs across Southeast Asia and is the most common cause of malaria in Malaysia. High parasitaemias can develop rapidly, and the risk of severe disease in adults is at least as high as in falciparum malaria. Prompt initiation of effective treatment is therefore essential. Intravenous artesunate is highly effective in severe knowlesi malaria and in those with moderately high parasitaemia but otherwise uncomplicated disease. Both chloroquine and artemisinin-combination therapy (ACT) are highly effective for uncomplicated knowlesi malaria, with faster parasite clearance times and lower anaemia rates with ACT. Given the difficulties with microscope diagnosis of P. knowlesi, a unified treatment strategy of ACT for all Plasmodium species is recommended in coendemic regions.

    AB - Plasmodium knowlesi occurs across Southeast Asia and is the most common cause of malaria in Malaysia. High parasitaemias can develop rapidly, and the risk of severe disease in adults is at least as high as in falciparum malaria. Prompt initiation of effective treatment is therefore essential. Intravenous artesunate is highly effective in severe knowlesi malaria and in those with moderately high parasitaemia but otherwise uncomplicated disease. Both chloroquine and artemisinin-combination therapy (ACT) are highly effective for uncomplicated knowlesi malaria, with faster parasite clearance times and lower anaemia rates with ACT. Given the difficulties with microscope diagnosis of P. knowlesi, a unified treatment strategy of ACT for all Plasmodium species is recommended in coendemic regions.

    KW - Artemisinin-combination therapy

    KW - Malaria

    KW - Plasmodium knowlesi

    KW - Treatment

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    DO - 10.1016/j.pt.2016.09.002

    M3 - Review article

    VL - 33

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    EP - 253

    JO - Trends in Parasitology

    JF - Trends in Parasitology

    SN - 0169-4758

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    ER -