The unsolved problem of otitis media in indigenous populations

a systematic review of upper respiratory and middle ear microbiology in indigenous children with otitis media

Andrea Coleman, Amanda Wood, Seweryn Bialasiewicz, Robert S. Ware, Robyn L. Marsh, Anders Cervin

    Research output: Contribution to journalReview articleResearchpeer-review

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    Abstract

    Background: Otitis media (OM) imposes a great burden of disease in indigenous populations around the world, despite a variety of treatment and prevention programs. Improved understanding of the pathogenesis of OM in indigenous populations is required to advance treatment and reduce prevalence.We conducted a systematic review of the literature exploring the upper airway and middle ear microbiota in relation to OM in indigenous children.


    Methods: Papers targeting microbiota in relation to OM in children< 18 years indigenous to Australia, New Zealand, North America, and Greenland were sought. MEDLINE, CINAHL, EMBASE, Cochrane Library, and Informit databases were searched using key words. Two independent reviewers screened titles, abstracts, and then full-text papers against inclusion criteria according to PRISMA guidelines.


    Results: Twenty-five papers considering indigenous Australian,Alaskan, and Greenlandic children were included. There were high rates of nasopharyngeal colonization with the three main otopathogens (Haemophilusinfluenzae, Streptococcus pneumoniae, and Moraxella catarrhalis) in indigenous children with OM. Middle ear samples had lower rates of otopathogen detection,although detection rates increased when molecular methods were used.Pseudomonas aeruginosa and Staphylococcus aureus were commonly detected in middle ear discharge of children with chronic suppurative OM. There was a significant heterogeneity between studies, particularly in microbiological methods, which were largely limited to culture-based detection of the main otopathogens.


    Conclusions: 
    There are high rates of otopathogen colonization in indigenous children with OM. Chronic suppurative OM appears to be associated with a different microbial profile.Beyond the main otopathogens, the data are limited. Further research is required to explore the entire upper respiratory tract/middle ear microbiota in relation to OM, with the inclusion of healthy indigenous peers as controls.

    Original languageEnglish
    Article number199
    Pages (from-to)1-15
    Number of pages15
    JournalMicrobiome
    Volume6
    DOIs
    Publication statusPublished - 5 Nov 2018

    Fingerprint

    Otitis Media
    Middle Ear
    Microbiology
    Population Groups
    Microbiota
    Suppurative Otitis Media
    Greenland
    Moraxella (Branhamella) catarrhalis
    North America
    Streptococcus pneumoniae
    New Zealand
    MEDLINE
    Respiratory System
    Pseudomonas aeruginosa
    Libraries
    Staphylococcus aureus
    Databases
    Guidelines
    Therapeutics
    Research

    Cite this

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    title = "The unsolved problem of otitis media in indigenous populations: a systematic review of upper respiratory and middle ear microbiology in indigenous children with otitis media",
    abstract = "Background: Otitis media (OM) imposes a great burden of disease in indigenous populations around the world, despite a variety of treatment and prevention programs. Improved understanding of the pathogenesis of OM in indigenous populations is required to advance treatment and reduce prevalence.We conducted a systematic review of the literature exploring the upper airway and middle ear microbiota in relation to OM in indigenous children.Methods: Papers targeting microbiota in relation to OM in children< 18 years indigenous to Australia, New Zealand, North America, and Greenland were sought. MEDLINE, CINAHL, EMBASE, Cochrane Library, and Informit databases were searched using key words. Two independent reviewers screened titles, abstracts, and then full-text papers against inclusion criteria according to PRISMA guidelines.Results: Twenty-five papers considering indigenous Australian,Alaskan, and Greenlandic children were included. There were high rates of nasopharyngeal colonization with the three main otopathogens (Haemophilusinfluenzae, Streptococcus pneumoniae, and Moraxella catarrhalis) in indigenous children with OM. Middle ear samples had lower rates of otopathogen detection,although detection rates increased when molecular methods were used.Pseudomonas aeruginosa and Staphylococcus aureus were commonly detected in middle ear discharge of children with chronic suppurative OM. There was a significant heterogeneity between studies, particularly in microbiological methods, which were largely limited to culture-based detection of the main otopathogens.Conclusions: There are high rates of otopathogen colonization in indigenous children with OM. Chronic suppurative OM appears to be associated with a different microbial profile.Beyond the main otopathogens, the data are limited. Further research is required to explore the entire upper respiratory tract/middle ear microbiota in relation to OM, with the inclusion of healthy indigenous peers as controls.",
    keywords = "Indigenous, Microbiota, Otitis media, Pediatrics, Systematic review",
    author = "Andrea Coleman and Amanda Wood and Seweryn Bialasiewicz and Ware, {Robert S.} and Marsh, {Robyn L.} and Anders Cervin",
    year = "2018",
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    language = "English",
    volume = "6",
    pages = "1--15",
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    The unsolved problem of otitis media in indigenous populations : a systematic review of upper respiratory and middle ear microbiology in indigenous children with otitis media. / Coleman, Andrea; Wood, Amanda; Bialasiewicz, Seweryn; Ware, Robert S.; Marsh, Robyn L.; Cervin, Anders.

    In: Microbiome, Vol. 6, 199, 05.11.2018, p. 1-15.

    Research output: Contribution to journalReview articleResearchpeer-review

    TY - JOUR

    T1 - The unsolved problem of otitis media in indigenous populations

    T2 - a systematic review of upper respiratory and middle ear microbiology in indigenous children with otitis media

    AU - Coleman, Andrea

    AU - Wood, Amanda

    AU - Bialasiewicz, Seweryn

    AU - Ware, Robert S.

    AU - Marsh, Robyn L.

    AU - Cervin, Anders

    PY - 2018/11/5

    Y1 - 2018/11/5

    N2 - Background: Otitis media (OM) imposes a great burden of disease in indigenous populations around the world, despite a variety of treatment and prevention programs. Improved understanding of the pathogenesis of OM in indigenous populations is required to advance treatment and reduce prevalence.We conducted a systematic review of the literature exploring the upper airway and middle ear microbiota in relation to OM in indigenous children.Methods: Papers targeting microbiota in relation to OM in children< 18 years indigenous to Australia, New Zealand, North America, and Greenland were sought. MEDLINE, CINAHL, EMBASE, Cochrane Library, and Informit databases were searched using key words. Two independent reviewers screened titles, abstracts, and then full-text papers against inclusion criteria according to PRISMA guidelines.Results: Twenty-five papers considering indigenous Australian,Alaskan, and Greenlandic children were included. There were high rates of nasopharyngeal colonization with the three main otopathogens (Haemophilusinfluenzae, Streptococcus pneumoniae, and Moraxella catarrhalis) in indigenous children with OM. Middle ear samples had lower rates of otopathogen detection,although detection rates increased when molecular methods were used.Pseudomonas aeruginosa and Staphylococcus aureus were commonly detected in middle ear discharge of children with chronic suppurative OM. There was a significant heterogeneity between studies, particularly in microbiological methods, which were largely limited to culture-based detection of the main otopathogens.Conclusions: There are high rates of otopathogen colonization in indigenous children with OM. Chronic suppurative OM appears to be associated with a different microbial profile.Beyond the main otopathogens, the data are limited. Further research is required to explore the entire upper respiratory tract/middle ear microbiota in relation to OM, with the inclusion of healthy indigenous peers as controls.

    AB - Background: Otitis media (OM) imposes a great burden of disease in indigenous populations around the world, despite a variety of treatment and prevention programs. Improved understanding of the pathogenesis of OM in indigenous populations is required to advance treatment and reduce prevalence.We conducted a systematic review of the literature exploring the upper airway and middle ear microbiota in relation to OM in indigenous children.Methods: Papers targeting microbiota in relation to OM in children< 18 years indigenous to Australia, New Zealand, North America, and Greenland were sought. MEDLINE, CINAHL, EMBASE, Cochrane Library, and Informit databases were searched using key words. Two independent reviewers screened titles, abstracts, and then full-text papers against inclusion criteria according to PRISMA guidelines.Results: Twenty-five papers considering indigenous Australian,Alaskan, and Greenlandic children were included. There were high rates of nasopharyngeal colonization with the three main otopathogens (Haemophilusinfluenzae, Streptococcus pneumoniae, and Moraxella catarrhalis) in indigenous children with OM. Middle ear samples had lower rates of otopathogen detection,although detection rates increased when molecular methods were used.Pseudomonas aeruginosa and Staphylococcus aureus were commonly detected in middle ear discharge of children with chronic suppurative OM. There was a significant heterogeneity between studies, particularly in microbiological methods, which were largely limited to culture-based detection of the main otopathogens.Conclusions: There are high rates of otopathogen colonization in indigenous children with OM. Chronic suppurative OM appears to be associated with a different microbial profile.Beyond the main otopathogens, the data are limited. Further research is required to explore the entire upper respiratory tract/middle ear microbiota in relation to OM, with the inclusion of healthy indigenous peers as controls.

    KW - Indigenous

    KW - Microbiota

    KW - Otitis media

    KW - Pediatrics

    KW - Systematic review

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    U2 - 10.1186/s40168-018-0577-2

    DO - 10.1186/s40168-018-0577-2

    M3 - Review article

    VL - 6

    SP - 1

    EP - 15

    JO - Microbiome

    JF - Microbiome

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