The use of high-dose insulin-glucose euglycemia in beta-blocker overdose: A case report

Colin B. Page; L. Peter Hacket; Geoffrey K. Isbister

doi:10.1007/BF03161225

The use of high-dose insulin-glucose euglycemia in beta-blocker overdose: A case report

Colin B. Page, L. Peter Hacket, Geoffrey K. Isbister

Global and Tropical Health

Research output: Contribution to journal › Article › peer-review

Abstract

The management of life-threatening beta-blocker toxicity and its associated low cardiac output state is clinically challenging. Previous case reports and case series describe the use of hyperinsulinemia/euglycemia therapy in mono-ingestions of calcium channel blockers and mixed ingestions, including calcium channel and beta-blockers. In this case report we describe the use of high-dose insulin (10 IU/kg per hour) in a case of massive metoprolol ingestion (5 g) in which hypotension was unresponsive to conventional therapies. Although the metoprolol concentrations measured in plasma were approximately 100-200 times therapeutic concentrations, the pharmacokinetics appeared to be similar to therapeutic metoprolol dosing.

Original language	English
Pages (from-to)	139-143
Number of pages	5
Journal	Journal of Medical Toxicology
Volume	5
Issue number	3
DOIs	https://doi.org/10.1007/BF03161225
Publication status	Published - 1 Sept 2009

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The use of high-dose insulin-glucose euglycemia in beta-blocker overdose: A case report

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