The utility of elective flexible bronchoscopy to improve quality of life and clinical outcomes for children: A systematic review

Rahul J. Thomas, Stephanie T. Yerkovich, Vikas Goyal, Anne B. Chang, Cameron Rutter, Ian Brent Masters, Julie M. Marchant

    Research output: Contribution to journalReview articlepeer-review

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    Abstract

    Introduction: Elective flexible bronchoscopy (FB) is now widely available and standard practice for a variety of indications in children with respiratory conditions. However, there is limited evidence regarding the utility of elective FB in children. This systematic review (SRs) aimed to determine the utility of FB on its impact in clinical decision making and quality of life (QoL).

    Methods: We searched Pubmed, Cochrane central register of controlled trials, Embase, World Health Organization Clinical Trials Registry Platform and Cochrane database of SRs from inception to April 20, 2023. We included SRs and randomized controlled trials (RCTs) that used parallel group design (comparing use of elective FB vs. no FB, or a wait-list approach [early FB vs. usual wait FB]) in children aged ≤ 18 years. Our protocol was prospectively registered and used Cochrane methodology for systemic reviews of interventions. 

    Results: Our search identified 859 articles; 102 duplicates were removed, and 753 articles were excluded by title and abstract. Four full text articles were reviewed and subsequently excluded, as none met the inclusion criteria outlined in our patient, intervention, comparator, outcome measures framework.

    Conclusions: There is a paucity of high-quality RCT evidence to support the routine use of elective FB in children with respiratory conditions. However, available retrospective and a single prospective study demonstrate the high utility of FB in the elective pediatric setting.

    Registration: PROSPERO CRD42021291305.

    Original languageEnglish
    Pages (from-to)1-17
    Number of pages17
    JournalPediatric Pulmonology
    DOIs
    Publication statusE-pub ahead of print - 2024

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