Therapeutic potential of neurogenesis and melatonin regulation in Alzheimer's disease

Mazel Mihardja, Jaydeep Roy, Kan Yin Wong, Luca Aquili, Boon Chin Heng, Ying Shing Chan, Man Lung Fung, Lee Wei Lim

Research output: Contribution to journalReview article

Abstract

Alzheimer's disease (AD) is an age-related neurodegenerative disorder characterized by the hallmark pathologies of amyloid-beta plaques and neurofibrillary tangles. Symptoms of this devastating disease include behavioral changes and deterioration of higher cognitive functions. Impairment of neurogenesis has also been shown to occur in AD, which adversely impacts new neuronal cell growth, differentiation, and survival. This impairment possibly results from the cumulative effects of the various pathologies of AD. Preclinical studies have suggested that the administration of melatonin-the pineal hormone primarily responsible for the regulation of the circadian rhythm-targets the effects of AD pathologies and improves cognitive impairment. It is postulated that by mitigating the effect of these pathologies, melatonin can also rescue neurogenesis impairment. This review aims to explore the effect of AD pathologies on neurogenesis, as well as the mechanisms by which melatonin is able to ameliorate AD pathologies to potentially promote neurogenesis.

Original languageEnglish
Pages (from-to)43-62
Number of pages20
JournalAnnals of the New York Academy of Sciences
Volume1478
Issue number1
Early online date22 Jul 2020
DOIs
Publication statusPublished - 1 Oct 2020

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