Toward the prevention of coronavirus infection: What role can polymers play?

X. Jiang; Z. Li; D. J. Young; M. Liu; C. Wu; Y. L. Wu; X. J. Loh

doi:10.1016/j.mtadv.2021.100140

Toward the prevention of coronavirus infection: What role can polymers play?

X. Jiang, Z. Li, D. J. Young, M. Liu, C. Wu, Y. L. Wu, X. J. Loh

CDU College of Engineering, IT and Environment

Research output: Contribution to journal › Review article › peer-review

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Abstract

Severe acute respiratory syndrome–associated coronavirus 2 has caused a global public health crisis with high rates of infection and mortality. Treatment and prevention approaches include vaccine development, the design of small-molecule antiviral drugs, and macromolecular neutralizing antibodies. Polymers have been designed for effective virus inhibition and as antiviral drug delivery carriers. This review summarizes recent progress and provides a perspective on polymer-based approaches for the treatment and prevention of coronavirus infection. These polymer-based partners include polyanion/polycations, dendritic polymers, macromolecular prodrugs, and polymeric drug delivery systems that have the potential to significantly improve the efficacy of antiviral therapeutics.

Original language	English
Article number	100140
Pages (from-to)	1-11
Number of pages	11
Journal	Materials Today Advances
Volume	10
Early online date	20 Mar 2021
DOIs	https://doi.org/10.1016/j.mtadv.2021.100140
Publication status	Published - Jun 2021

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10.1016/j.mtadv.2021.100140

41726086-oaFinal published version, 2.46 MBLicence: CC BY
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title = "Toward the prevention of coronavirus infection: What role can polymers play?",

abstract = "Severe acute respiratory syndrome–associated coronavirus 2 has caused a global public health crisis with high rates of infection and mortality. Treatment and prevention approaches include vaccine development, the design of small-molecule antiviral drugs, and macromolecular neutralizing antibodies. Polymers have been designed for effective virus inhibition and as antiviral drug delivery carriers. This review summarizes recent progress and provides a perspective on polymer-based approaches for the treatment and prevention of coronavirus infection. These polymer-based partners include polyanion/polycations, dendritic polymers, macromolecular prodrugs, and polymeric drug delivery systems that have the potential to significantly improve the efficacy of antiviral therapeutics.",

keywords = "Antiviral, Biomaterials, Drug delivery, Polyanion, Polycation",

author = "X. Jiang and Z. Li and Young, {D. J.} and M. Liu and C. Wu and Wu, {Y. L.} and Loh, {X. J.}",

note = "Funding Information: X.J. and Z.L. contributed equally to this work. This project is supported by the Natural Science Foundation of China ( 81773688 , U1903119 , 81971724 , and 81773661 ) and the National Major Scientific and Technological Special Project for {\textquoteleft}Significant New Drugs Development{\textquoteright} (No. 2020ZX09201005), and Agency for Science, Technology and Research (A∗STAR). Funding Information: X.J. and Z.L. contributed equally to this work. This project is supported by the Natural Science Foundation of China (81773688, U1903119, 81971724, and 81773661) and the National Major Scientific and Technological Special Project for ?Significant New Drugs Development? (No. 2020ZX09201005), and Agency for Science, Technology and Research (A?STAR). Publisher Copyright: {\textcopyright} 2021 The Authors Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",

year = "2021",

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doi = "10.1016/j.mtadv.2021.100140",

language = "English",

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AU - Young, D. J.

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AU - Wu, C.

AU - Wu, Y. L.

AU - Loh, X. J.

N1 - Funding Information: X.J. and Z.L. contributed equally to this work. This project is supported by the Natural Science Foundation of China ( 81773688 , U1903119 , 81971724 , and 81773661 ) and the National Major Scientific and Technological Special Project for ‘Significant New Drugs Development’ (No. 2020ZX09201005), and Agency for Science, Technology and Research (A∗STAR). Funding Information: X.J. and Z.L. contributed equally to this work. This project is supported by the Natural Science Foundation of China (81773688, U1903119, 81971724, and 81773661) and the National Major Scientific and Technological Special Project for ?Significant New Drugs Development? (No. 2020ZX09201005), and Agency for Science, Technology and Research (A?STAR). Publisher Copyright: © 2021 The Authors Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

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N2 - Severe acute respiratory syndrome–associated coronavirus 2 has caused a global public health crisis with high rates of infection and mortality. Treatment and prevention approaches include vaccine development, the design of small-molecule antiviral drugs, and macromolecular neutralizing antibodies. Polymers have been designed for effective virus inhibition and as antiviral drug delivery carriers. This review summarizes recent progress and provides a perspective on polymer-based approaches for the treatment and prevention of coronavirus infection. These polymer-based partners include polyanion/polycations, dendritic polymers, macromolecular prodrugs, and polymeric drug delivery systems that have the potential to significantly improve the efficacy of antiviral therapeutics.

AB - Severe acute respiratory syndrome–associated coronavirus 2 has caused a global public health crisis with high rates of infection and mortality. Treatment and prevention approaches include vaccine development, the design of small-molecule antiviral drugs, and macromolecular neutralizing antibodies. Polymers have been designed for effective virus inhibition and as antiviral drug delivery carriers. This review summarizes recent progress and provides a perspective on polymer-based approaches for the treatment and prevention of coronavirus infection. These polymer-based partners include polyanion/polycations, dendritic polymers, macromolecular prodrugs, and polymeric drug delivery systems that have the potential to significantly improve the efficacy of antiviral therapeutics.

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Toward the prevention of coronavirus infection: What role can polymers play?

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