Tracing Ancient Human Migrations into Sahul Using Hepatitis B Virus Genomes

Lilly K.W. Yuen, Margaret Littlejohn, Sebastián Duchêne, Rosalind Edwards, Sarah Bukulatjpi, Paula Binks, Kathy Jackson, Jane Davies, Joshua S. Davis, Steven Y.C. Tong, Stephen Locarnini

    Research output: Contribution to journalArticleResearchpeer-review

    Abstract

    The entry point and timing of ancient human migration into continental Sahul (the combined landmass of Australia, New Guinea, and Tasmania) are subject to debate. Unique strains of hepatitis B virus (HBV) are endemic among modern-day Australian Aboriginals (HBV/C4) and Indigenous Melanesians (HBV/C3). We postulated that HBV genomes could be used to infer human population movements because the main HBV transmission route in endemic populations is via mother-to-child for genotypes B and C infections. Phylogenetic and phylogeographic analyses of HBV genomes inferred the origin of HBV/C4 to be >59 thousand years ago (ka) (95% HPD: 34-85 ka), and most likely to have occurred on the Sunda Shelf (southeast extension of the continental shelf of Southeast Asia). Our analysis further suggested an age of >51 ka (95% Highest Posterior Density (HPD): 36-67 ka) for the most recent common ancestor of HBV/C4 in Australia, correlating with the arrival time of anatomically modern humans into Australia, with the entry point suggested along a southern route via Timor. While we also inferred the origin of HBC/C3 to be on the Sunda Shelf, our analyses suggested that it was carried into Melanesia by Indigenous Melanesians who migrated through New Guinea north of the highlands. These findings reveal that HBV genomes can be used to infer ancient human population movements.

    Original languageEnglish
    Pages (from-to)942-954
    Number of pages13
    JournalMolecular Biology and Evolution
    Volume36
    Issue number5
    Early online date19 Feb 2019
    DOIs
    Publication statusPublished - 1 May 2019

    Fingerprint

    Human Migration
    hepatitis
    Hepatitis B virus
    virus
    genome
    Genome
    New Guinea
    human population
    Melanesia
    Tasmania
    Timor
    Population
    human migration
    Southeastern Asia
    Indonesia
    virus transmission
    common ancestry
    arrival time
    South East Asia
    continental shelf

    Cite this

    Yuen, L. K. W., Littlejohn, M., Duchêne, S., Edwards, R., Bukulatjpi, S., Binks, P., ... Locarnini, S. (2019). Tracing Ancient Human Migrations into Sahul Using Hepatitis B Virus Genomes. Molecular Biology and Evolution, 36(5), 942-954. https://doi.org/10.1093/molbev/msz021
    Yuen, Lilly K.W. ; Littlejohn, Margaret ; Duchêne, Sebastián ; Edwards, Rosalind ; Bukulatjpi, Sarah ; Binks, Paula ; Jackson, Kathy ; Davies, Jane ; Davis, Joshua S. ; Tong, Steven Y.C. ; Locarnini, Stephen. / Tracing Ancient Human Migrations into Sahul Using Hepatitis B Virus Genomes. In: Molecular Biology and Evolution. 2019 ; Vol. 36, No. 5. pp. 942-954.
    @article{05d19f7285294f02b079a10c1e4cd2d7,
    title = "Tracing Ancient Human Migrations into Sahul Using Hepatitis B Virus Genomes",
    abstract = "The entry point and timing of ancient human migration into continental Sahul (the combined landmass of Australia, New Guinea, and Tasmania) are subject to debate. Unique strains of hepatitis B virus (HBV) are endemic among modern-day Australian Aboriginals (HBV/C4) and Indigenous Melanesians (HBV/C3). We postulated that HBV genomes could be used to infer human population movements because the main HBV transmission route in endemic populations is via mother-to-child for genotypes B and C infections. Phylogenetic and phylogeographic analyses of HBV genomes inferred the origin of HBV/C4 to be >59 thousand years ago (ka) (95{\%} HPD: 34-85 ka), and most likely to have occurred on the Sunda Shelf (southeast extension of the continental shelf of Southeast Asia). Our analysis further suggested an age of >51 ka (95{\%} Highest Posterior Density (HPD): 36-67 ka) for the most recent common ancestor of HBV/C4 in Australia, correlating with the arrival time of anatomically modern humans into Australia, with the entry point suggested along a southern route via Timor. While we also inferred the origin of HBC/C3 to be on the Sunda Shelf, our analyses suggested that it was carried into Melanesia by Indigenous Melanesians who migrated through New Guinea north of the highlands. These findings reveal that HBV genomes can be used to infer ancient human population movements.",
    keywords = "evolution, hepatitis B virus, human migration, Indigenous Australians",
    author = "Yuen, {Lilly K.W.} and Margaret Littlejohn and Sebasti{\'a}n Duch{\^e}ne and Rosalind Edwards and Sarah Bukulatjpi and Paula Binks and Kathy Jackson and Jane Davies and Davis, {Joshua S.} and Tong, {Steven Y.C.} and Stephen Locarnini",
    year = "2019",
    month = "5",
    day = "1",
    doi = "10.1093/molbev/msz021",
    language = "English",
    volume = "36",
    pages = "942--954",
    journal = "Molecular Biology and Evolution",
    issn = "0737-4038",
    publisher = "Oxford University Press",
    number = "5",

    }

    Yuen, LKW, Littlejohn, M, Duchêne, S, Edwards, R, Bukulatjpi, S, Binks, P, Jackson, K, Davies, J, Davis, JS, Tong, SYC & Locarnini, S 2019, 'Tracing Ancient Human Migrations into Sahul Using Hepatitis B Virus Genomes', Molecular Biology and Evolution, vol. 36, no. 5, pp. 942-954. https://doi.org/10.1093/molbev/msz021

    Tracing Ancient Human Migrations into Sahul Using Hepatitis B Virus Genomes. / Yuen, Lilly K.W.; Littlejohn, Margaret; Duchêne, Sebastián; Edwards, Rosalind; Bukulatjpi, Sarah; Binks, Paula; Jackson, Kathy; Davies, Jane; Davis, Joshua S.; Tong, Steven Y.C.; Locarnini, Stephen.

    In: Molecular Biology and Evolution, Vol. 36, No. 5, 01.05.2019, p. 942-954.

    Research output: Contribution to journalArticleResearchpeer-review

    TY - JOUR

    T1 - Tracing Ancient Human Migrations into Sahul Using Hepatitis B Virus Genomes

    AU - Yuen, Lilly K.W.

    AU - Littlejohn, Margaret

    AU - Duchêne, Sebastián

    AU - Edwards, Rosalind

    AU - Bukulatjpi, Sarah

    AU - Binks, Paula

    AU - Jackson, Kathy

    AU - Davies, Jane

    AU - Davis, Joshua S.

    AU - Tong, Steven Y.C.

    AU - Locarnini, Stephen

    PY - 2019/5/1

    Y1 - 2019/5/1

    N2 - The entry point and timing of ancient human migration into continental Sahul (the combined landmass of Australia, New Guinea, and Tasmania) are subject to debate. Unique strains of hepatitis B virus (HBV) are endemic among modern-day Australian Aboriginals (HBV/C4) and Indigenous Melanesians (HBV/C3). We postulated that HBV genomes could be used to infer human population movements because the main HBV transmission route in endemic populations is via mother-to-child for genotypes B and C infections. Phylogenetic and phylogeographic analyses of HBV genomes inferred the origin of HBV/C4 to be >59 thousand years ago (ka) (95% HPD: 34-85 ka), and most likely to have occurred on the Sunda Shelf (southeast extension of the continental shelf of Southeast Asia). Our analysis further suggested an age of >51 ka (95% Highest Posterior Density (HPD): 36-67 ka) for the most recent common ancestor of HBV/C4 in Australia, correlating with the arrival time of anatomically modern humans into Australia, with the entry point suggested along a southern route via Timor. While we also inferred the origin of HBC/C3 to be on the Sunda Shelf, our analyses suggested that it was carried into Melanesia by Indigenous Melanesians who migrated through New Guinea north of the highlands. These findings reveal that HBV genomes can be used to infer ancient human population movements.

    AB - The entry point and timing of ancient human migration into continental Sahul (the combined landmass of Australia, New Guinea, and Tasmania) are subject to debate. Unique strains of hepatitis B virus (HBV) are endemic among modern-day Australian Aboriginals (HBV/C4) and Indigenous Melanesians (HBV/C3). We postulated that HBV genomes could be used to infer human population movements because the main HBV transmission route in endemic populations is via mother-to-child for genotypes B and C infections. Phylogenetic and phylogeographic analyses of HBV genomes inferred the origin of HBV/C4 to be >59 thousand years ago (ka) (95% HPD: 34-85 ka), and most likely to have occurred on the Sunda Shelf (southeast extension of the continental shelf of Southeast Asia). Our analysis further suggested an age of >51 ka (95% Highest Posterior Density (HPD): 36-67 ka) for the most recent common ancestor of HBV/C4 in Australia, correlating with the arrival time of anatomically modern humans into Australia, with the entry point suggested along a southern route via Timor. While we also inferred the origin of HBC/C3 to be on the Sunda Shelf, our analyses suggested that it was carried into Melanesia by Indigenous Melanesians who migrated through New Guinea north of the highlands. These findings reveal that HBV genomes can be used to infer ancient human population movements.

    KW - evolution

    KW - hepatitis B virus

    KW - human migration

    KW - Indigenous Australians

    UR - http://www.scopus.com/inward/record.url?scp=85065656250&partnerID=8YFLogxK

    U2 - 10.1093/molbev/msz021

    DO - 10.1093/molbev/msz021

    M3 - Article

    VL - 36

    SP - 942

    EP - 954

    JO - Molecular Biology and Evolution

    JF - Molecular Biology and Evolution

    SN - 0737-4038

    IS - 5

    ER -

    Yuen LKW, Littlejohn M, Duchêne S, Edwards R, Bukulatjpi S, Binks P et al. Tracing Ancient Human Migrations into Sahul Using Hepatitis B Virus Genomes. Molecular Biology and Evolution. 2019 May 1;36(5):942-954. https://doi.org/10.1093/molbev/msz021