Tracing the transmission of mpox through wastewater surveillance in Southeast Asia

Dhammika Leshan Wannigama; Mohan Amarasiri; Phatthranit Phattharapornjaroen; Cameron Hurst; Charin Modchang; Sudarat Chadsuthi; Suparinthon Anupong; Kazuhiko Miyanaga; Longzhu Cui; Wanwara Thuptimdang; S. M. Ali Hosseini Rad; Stefan Fernandez; Angkana T. Huang; Porames Vatanaprasan; Dylan John Jay; Thammakorn Saethang; Sirirat Luk-In; Robin James Storer; Puey Ounjai; Naveen Kumar Devanga Ragupathi; Phitsanuruk Kanthawee; Daisuke Sano; Takashi Furukawa; Kazunari Sei; Asada Leelahavanichkul; Talerngsak Kanjanabuch; Paul G. Higgins; Asuka Nanbo; Anthony Kicic; Andrew C. Singer; Tanittha Chatsuwan; Sam Trowsdale; Richard Siow; Kenji Shibuya; Shuichi Abe; Hitoshi Ishikawa; Parichart Hongsing

doi:10.1093/jtm/taad096

Tracing the transmission of mpox through wastewater surveillance in Southeast Asia

Dhammika Leshan Wannigama, Mohan Amarasiri, Phatthranit Phattharapornjaroen, Cameron Hurst, Charin Modchang, Sudarat Chadsuthi, Suparinthon Anupong, Kazuhiko Miyanaga, Longzhu Cui, Wanwara Thuptimdang, S. M. Ali Hosseini Rad, Stefan Fernandez, Angkana T. Huang, Porames Vatanaprasan, Dylan John Jay, Thammakorn Saethang, Sirirat Luk-In, Robin James Storer, Puey Ounjai, Naveen Kumar Devanga RagupathiPhitsanuruk Kanthawee, Daisuke Sano, Takashi Furukawa, Kazunari Sei, Asada Leelahavanichkul, Talerngsak Kanjanabuch, Paul G. Higgins, Asuka Nanbo, Anthony Kicic, Andrew C. Singer, Tanittha Chatsuwan, Sam Trowsdale, Richard Siow, Kenji Shibuya, Shuichi Abe, Hitoshi Ishikawa, Parichart Hongsing

Molly Wardaguga Research Centre

Research output: Contribution to journal › Letter › peer-review

12 Citations (Scopus)

Abstract

High population density and tourism in Southeast Asia increase the risk of mpox due to frequent interpersonal contacts. Our wastewater surveillance in six Southeast Asian countries revealed positive signals for Monkeypox virus (MPXV) DNA, indicating local transmission. This alerts clinicians and helps allocate resources like testing, vaccines and therapeutics in resource-limited countries.

Original language	English
Article number	taad096
Pages (from-to)	1-7
Number of pages	7
Journal	Journal of Travel Medicine
Volume	30
Issue number	5
DOIs	https://doi.org/10.1093/jtm/taad096
Publication status	Published - 1 Jul 2023

Bibliographical note

Funding Information:
D.L.W. was supported by Balvi Filantropic Fund and Chulalongkorn University (Second Century Fund-C2F Postdoctoral Fellowship), University of Western Australia (Overseas Research Experience Fellowship) and Yamagata Prefectural Central Hospital, Yamagata, Japan (Clinical Residency Fellowship). C.M. was supported by the Centre of Excellence in Mathematics, Ministry of Higher Education, Science, Research and Innovation, Thailand, Center of Excellence on Medical Biotechnology (CEMB), and Thailand Center of Excellence in Physics (ThEP). A.K. is a Rothwell Family Fellow. The funder(s) had no role in study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the article for publication. Acknowledgements

Funding Information:
D.L.W. was supported by Balvi Filantropic Fund and Chulalongkorn University (Second Century Fund-C2F Postdoctoral Fellowship), University of Western Australia (Overseas Research Experience Fellowship) and Yamagata Prefectural Central Hospital, Yamagata, Japan (Clinical Residency Fellowship). C.M. was supported by the Centre of Excellence in Mathematics, Ministry of Higher Education, Science, Research and Innovation, Thailand, Center of Excellence on Medical Biotechnology (CEMB), and Thailand Center of Excellence in Physics (ThEP). A.K. is a Rothwell Family Fellow. The funder(s) had no role in study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the article for publication. We thank all the volunteers who kindly supported with sample collection. Also, thanks to Dr Ong-orn Prasarnphanich at the United States Centers for Disease Control and Prevention (CDC) Thailand for technical support and the previous Chargé d’Affaires of the United States of America to Thailand (U.S. Embassy & Consulate in Thailand), Mr Michael Heath, for facilitating collaboration with the CDC and Armed Forces Research Institute of Medical Sciences (AFRIMS). We also thank the LGBTQIA+ community in Thailand, Lao PDR, Myanmar, Cambodia, Vietnam and Indonesia for generous support with sample collection, TEDxChiangMai team and Martin Venzky-Stalling for facilitating platform for collaboration, and marginalized, vulnerable indigenous communities in northern Thailand, Lao PDR, Myanmar, Cambodia, Vietnam and Indonesia for support with sample collection. Special thanks to Nuttawut Kietchaiyakorn for helping with the illustrations.

Publisher Copyright:
© 2023 International Society of Travel Medicine. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: [email protected].

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10.1093/jtm/taad096

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Wannigama, D. L., Amarasiri, M., Phattharapornjaroen, P., Hurst, C., Modchang, C., Chadsuthi, S., Anupong, S., Miyanaga, K., Cui, L., Thuptimdang, W., Ali Hosseini Rad, S. M., Fernandez, S., Huang, A. T., Vatanaprasan, P., Jay, D. J., Saethang, T., Luk-In, S., Storer, R. J., Ounjai, P., ... Hongsing, P. (2023). Tracing the transmission of mpox through wastewater surveillance in Southeast Asia. Journal of Travel Medicine, 30(5), 1-7. Article taad096. https://doi.org/10.1093/jtm/taad096

@article{a82b8b8ea1694100bbf4ce70023ab9d6,

title = "Tracing the transmission of mpox through wastewater surveillance in Southeast Asia",

abstract = "High population density and tourism in Southeast Asia increase the risk of mpox due to frequent interpersonal contacts. Our wastewater surveillance in six Southeast Asian countries revealed positive signals for Monkeypox virus (MPXV) DNA, indicating local transmission. This alerts clinicians and helps allocate resources like testing, vaccines and therapeutics in resource-limited countries.",

keywords = "mpox, Southeast Asia, surveillances, Tracing, transmission, wastewaters, WBE",

author = "Wannigama, {Dhammika Leshan} and Mohan Amarasiri and Phatthranit Phattharapornjaroen and Cameron Hurst and Charin Modchang and Sudarat Chadsuthi and Suparinthon Anupong and Kazuhiko Miyanaga and Longzhu Cui and Wanwara Thuptimdang and {Ali Hosseini Rad}, {S. M.} and Stefan Fernandez and Huang, {Angkana T.} and Porames Vatanaprasan and Jay, {Dylan John} and Thammakorn Saethang and Sirirat Luk-In and Storer, {Robin James} and Puey Ounjai and Ragupathi, {Naveen Kumar Devanga} and Phitsanuruk Kanthawee and Daisuke Sano and Takashi Furukawa and Kazunari Sei and Asada Leelahavanichkul and Talerngsak Kanjanabuch and Higgins, {Paul G.} and Asuka Nanbo and Anthony Kicic and Singer, {Andrew C.} and Tanittha Chatsuwan and Sam Trowsdale and Richard Siow and Kenji Shibuya and Shuichi Abe and Hitoshi Ishikawa and Parichart Hongsing",

note = "Funding Information: D.L.W. was supported by Balvi Filantropic Fund and Chulalongkorn University (Second Century Fund-C2F Postdoctoral Fellowship), University of Western Australia (Overseas Research Experience Fellowship) and Yamagata Prefectural Central Hospital, Yamagata, Japan (Clinical Residency Fellowship). C.M. was supported by the Centre of Excellence in Mathematics, Ministry of Higher Education, Science, Research and Innovation, Thailand, Center of Excellence on Medical Biotechnology (CEMB), and Thailand Center of Excellence in Physics (ThEP). A.K. is a Rothwell Family Fellow. The funder(s) had no role in study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the article for publication. Acknowledgements Funding Information: D.L.W. was supported by Balvi Filantropic Fund and Chulalongkorn University (Second Century Fund-C2F Postdoctoral Fellowship), University of Western Australia (Overseas Research Experience Fellowship) and Yamagata Prefectural Central Hospital, Yamagata, Japan (Clinical Residency Fellowship). C.M. was supported by the Centre of Excellence in Mathematics, Ministry of Higher Education, Science, Research and Innovation, Thailand, Center of Excellence on Medical Biotechnology (CEMB), and Thailand Center of Excellence in Physics (ThEP). A.K. is a Rothwell Family Fellow. The funder(s) had no role in study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the article for publication. We thank all the volunteers who kindly supported with sample collection. Also, thanks to Dr Ong-orn Prasarnphanich at the United States Centers for Disease Control and Prevention (CDC) Thailand for technical support and the previous Charg{\'e} d{\textquoteright}Affaires of the United States of America to Thailand (U.S. Embassy & Consulate in Thailand), Mr Michael Heath, for facilitating collaboration with the CDC and Armed Forces Research Institute of Medical Sciences (AFRIMS). We also thank the LGBTQIA+ community in Thailand, Lao PDR, Myanmar, Cambodia, Vietnam and Indonesia for generous support with sample collection, TEDxChiangMai team and Martin Venzky-Stalling for facilitating platform for collaboration, and marginalized, vulnerable indigenous communities in northern Thailand, Lao PDR, Myanmar, Cambodia, Vietnam and Indonesia for support with sample collection. Special thanks to Nuttawut Kietchaiyakorn for helping with the illustrations. Publisher Copyright: {\textcopyright} 2023 International Society of Travel Medicine. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: [email protected].",

year = "2023",

month = jul,

day = "1",

doi = "10.1093/jtm/taad096",

language = "English",

volume = "30",

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journal = "Journal of Travel Medicine",

issn = "1195-1982",

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Wannigama, DL, Amarasiri, M, Phattharapornjaroen, P, Hurst, C, Modchang, C, Chadsuthi, S, Anupong, S, Miyanaga, K, Cui, L, Thuptimdang, W, Ali Hosseini Rad, SM, Fernandez, S, Huang, AT, Vatanaprasan, P, Jay, DJ, Saethang, T, Luk-In, S, Storer, RJ, Ounjai, P, Ragupathi, NKD, Kanthawee, P, Sano, D, Furukawa, T, Sei, K, Leelahavanichkul, A, Kanjanabuch, T, Higgins, PG, Nanbo, A, Kicic, A, Singer, AC, Chatsuwan, T, Trowsdale, S, Siow, R, Shibuya, K, Abe, S, Ishikawa, H & Hongsing, P 2023, 'Tracing the transmission of mpox through wastewater surveillance in Southeast Asia', Journal of Travel Medicine, vol. 30, no. 5, taad096, pp. 1-7. https://doi.org/10.1093/jtm/taad096

TY - JOUR

T1 - Tracing the transmission of mpox through wastewater surveillance in Southeast Asia

AU - Wannigama, Dhammika Leshan

AU - Amarasiri, Mohan

AU - Phattharapornjaroen, Phatthranit

AU - Hurst, Cameron

AU - Modchang, Charin

AU - Chadsuthi, Sudarat

AU - Anupong, Suparinthon

AU - Miyanaga, Kazuhiko

AU - Cui, Longzhu

AU - Thuptimdang, Wanwara

AU - Ali Hosseini Rad, S. M.

AU - Fernandez, Stefan

AU - Huang, Angkana T.

AU - Vatanaprasan, Porames

AU - Jay, Dylan John

AU - Saethang, Thammakorn

AU - Luk-In, Sirirat

AU - Storer, Robin James

AU - Ounjai, Puey

AU - Ragupathi, Naveen Kumar Devanga

AU - Kanthawee, Phitsanuruk

AU - Sano, Daisuke

AU - Furukawa, Takashi

AU - Sei, Kazunari

AU - Leelahavanichkul, Asada

AU - Kanjanabuch, Talerngsak

AU - Higgins, Paul G.

AU - Nanbo, Asuka

AU - Kicic, Anthony

AU - Singer, Andrew C.

AU - Chatsuwan, Tanittha

AU - Trowsdale, Sam

AU - Siow, Richard

AU - Shibuya, Kenji

AU - Abe, Shuichi

AU - Ishikawa, Hitoshi

AU - Hongsing, Parichart

N1 - Funding Information: D.L.W. was supported by Balvi Filantropic Fund and Chulalongkorn University (Second Century Fund-C2F Postdoctoral Fellowship), University of Western Australia (Overseas Research Experience Fellowship) and Yamagata Prefectural Central Hospital, Yamagata, Japan (Clinical Residency Fellowship). C.M. was supported by the Centre of Excellence in Mathematics, Ministry of Higher Education, Science, Research and Innovation, Thailand, Center of Excellence on Medical Biotechnology (CEMB), and Thailand Center of Excellence in Physics (ThEP). A.K. is a Rothwell Family Fellow. The funder(s) had no role in study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the article for publication. Acknowledgements Funding Information: D.L.W. was supported by Balvi Filantropic Fund and Chulalongkorn University (Second Century Fund-C2F Postdoctoral Fellowship), University of Western Australia (Overseas Research Experience Fellowship) and Yamagata Prefectural Central Hospital, Yamagata, Japan (Clinical Residency Fellowship). C.M. was supported by the Centre of Excellence in Mathematics, Ministry of Higher Education, Science, Research and Innovation, Thailand, Center of Excellence on Medical Biotechnology (CEMB), and Thailand Center of Excellence in Physics (ThEP). A.K. is a Rothwell Family Fellow. The funder(s) had no role in study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the article for publication. We thank all the volunteers who kindly supported with sample collection. Also, thanks to Dr Ong-orn Prasarnphanich at the United States Centers for Disease Control and Prevention (CDC) Thailand for technical support and the previous Chargé d’Affaires of the United States of America to Thailand (U.S. Embassy & Consulate in Thailand), Mr Michael Heath, for facilitating collaboration with the CDC and Armed Forces Research Institute of Medical Sciences (AFRIMS). We also thank the LGBTQIA+ community in Thailand, Lao PDR, Myanmar, Cambodia, Vietnam and Indonesia for generous support with sample collection, TEDxChiangMai team and Martin Venzky-Stalling for facilitating platform for collaboration, and marginalized, vulnerable indigenous communities in northern Thailand, Lao PDR, Myanmar, Cambodia, Vietnam and Indonesia for support with sample collection. Special thanks to Nuttawut Kietchaiyakorn for helping with the illustrations. Publisher Copyright: © 2023 International Society of Travel Medicine. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: [email protected].

PY - 2023/7/1

Y1 - 2023/7/1

N2 - High population density and tourism in Southeast Asia increase the risk of mpox due to frequent interpersonal contacts. Our wastewater surveillance in six Southeast Asian countries revealed positive signals for Monkeypox virus (MPXV) DNA, indicating local transmission. This alerts clinicians and helps allocate resources like testing, vaccines and therapeutics in resource-limited countries.

AB - High population density and tourism in Southeast Asia increase the risk of mpox due to frequent interpersonal contacts. Our wastewater surveillance in six Southeast Asian countries revealed positive signals for Monkeypox virus (MPXV) DNA, indicating local transmission. This alerts clinicians and helps allocate resources like testing, vaccines and therapeutics in resource-limited countries.

KW - mpox

KW - Southeast Asia

KW - surveillances

KW - Tracing

KW - transmission

KW - wastewaters

KW - WBE

UR - http://www.scopus.com/inward/record.url?scp=85169847217&partnerID=8YFLogxK

U2 - 10.1093/jtm/taad096

DO - 10.1093/jtm/taad096

M3 - Letter

C2 - 37462504

AN - SCOPUS:85169847217

SN - 1195-1982

VL - 30

SP - 1

EP - 7

JO - Journal of Travel Medicine

JF - Journal of Travel Medicine

IS - 5

M1 - taad096

ER -

Tracing the transmission of mpox through wastewater surveillance in Southeast Asia

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