Trough Concentrations of Vancomycin: Adult therapeutic targets are not appropriate for Children

Claire L. Gordon, Chantelle Thompson, Jonathan R. Carapetis, John Turnidge, Charles Kilburn, Bart J. Currie

Research output: Contribution to journalReview articlepeer-review

39 Citations (Scopus)
127 Downloads (Pure)

Abstract

Despite the need for effective vancomycin therapy, there are few data guiding vancomycin monitoring in children. We reviewed retrospectively vancomycin use in children 1 month to 12 years of age. Initial and adjusted target trough vancomycin concentrations in serum were infrequently achieved regardless of the dosing schedule. Currently recommended trough concentrations need to be re-examined with a more detailed pharmacokinetic study in children.

Original languageEnglish
Pages (from-to)1269-1271
Number of pages3
JournalPediatric Infectious Disease Journal
Volume31
Issue number12
DOIs
Publication statusPublished - Dec 2012

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