Trough Concentrations of Vancomycin: Adult therapeutic targets are not appropriate for Children

Claire L. Gordon; Chantelle Thompson; Jonathan R. Carapetis; John Turnidge; Charles Kilburn; Bart J. Currie

doi:10.1097/INF.0b013e31826a3eaf

Trough Concentrations of Vancomycin: Adult therapeutic targets are not appropriate for Children

Claire L. Gordon, Chantelle Thompson, Jonathan R. Carapetis, John Turnidge, Charles Kilburn, Bart J. Currie

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Abstract

Despite the need for effective vancomycin therapy, there are few data guiding vancomycin monitoring in children. We reviewed retrospectively vancomycin use in children 1 month to 12 years of age. Initial and adjusted target trough vancomycin concentrations in serum were infrequently achieved regardless of the dosing schedule. Currently recommended trough concentrations need to be re-examined with a more detailed pharmacokinetic study in children.

Original language	English
Pages (from-to)	1269-1271
Number of pages	3
Journal	Pediatric Infectious Disease Journal
Volume	31
Issue number	12
DOIs	https://doi.org/10.1097/INF.0b013e31826a3eaf
Publication status	Published - Dec 2012

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AU - Kilburn, Charles

AU - Currie, Bart J.

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Trough Concentrations of Vancomycin: Adult therapeutic targets are not appropriate for Children

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