Tumor necrosis factor and lymphotoxin-α polymorphisms and severe malaria in African populations

Taane G. Clark, Mahamadou Diakite, Sarah Auburn, Susana Campino, Andrew E. Fry, Angela Green, Anna Richardson, Kerrin Small, Yik Y. Teo, Jonathan Wilson, Muminatou Jallow, Fatou Sisay-Joof, Margaret Pinder, Michael J. Griffiths, Norbert Peshu, Thomas N. Williams, Kevin Marsh, Malcolm E. Molyneux, Terrie E. Taylor, Kirk A. Rockett & 1 others Dominic P. Kwiatkowski

Research output: Contribution to journalArticleResearchpeer-review

Abstract

The tumor necrosis factor gene (TNF) and lymphotoxin-α gene (LTA) have long attracted attention as candidate genes for susceptibility traits for malaria, and several of their polymorphisms have been found to be associated with severe malaria (SM) phenotypes. In a large study involving > 10,000 individuals and encompassing 3 African populations, we found evidence to support the reported associations between the TNF -238 polymorphism and SM in The Gambia. However, no TNF/LTA polymorphisms were found to be associated with SM in cohorts in Kenya and Malawi. It has been suggested that the causal polymorphisms regulating the TNF and LTA responses may be located some distance from the genes. Therefore, more-detailed mapping of variants across TNF/LTA genes and their flanking regions in the Gambian and allied populations may need to be undertaken to find any causal polymorphisms.

Original languageEnglish
Pages (from-to)569-575
Number of pages7
JournalJournal of Infectious Diseases
Volume199
Issue number4
DOIs
Publication statusPublished - 2009
Externally publishedYes

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Lymphotoxin-alpha
Malaria
Tumor Necrosis Factor-alpha
Population
Genes
Gambia
Malawi
Kenya
Phenotype

Cite this

Clark, T. G., Diakite, M., Auburn, S., Campino, S., Fry, A. E., Green, A., ... Kwiatkowski, D. P. (2009). Tumor necrosis factor and lymphotoxin-α polymorphisms and severe malaria in African populations. Journal of Infectious Diseases, 199(4), 569-575. https://doi.org/10.1086/596320
Clark, Taane G. ; Diakite, Mahamadou ; Auburn, Sarah ; Campino, Susana ; Fry, Andrew E. ; Green, Angela ; Richardson, Anna ; Small, Kerrin ; Teo, Yik Y. ; Wilson, Jonathan ; Jallow, Muminatou ; Sisay-Joof, Fatou ; Pinder, Margaret ; Griffiths, Michael J. ; Peshu, Norbert ; Williams, Thomas N. ; Marsh, Kevin ; Molyneux, Malcolm E. ; Taylor, Terrie E. ; Rockett, Kirk A. ; Kwiatkowski, Dominic P. / Tumor necrosis factor and lymphotoxin-α polymorphisms and severe malaria in African populations. In: Journal of Infectious Diseases. 2009 ; Vol. 199, No. 4. pp. 569-575.
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title = "Tumor necrosis factor and lymphotoxin-α polymorphisms and severe malaria in African populations",
abstract = "The tumor necrosis factor gene (TNF) and lymphotoxin-α gene (LTA) have long attracted attention as candidate genes for susceptibility traits for malaria, and several of their polymorphisms have been found to be associated with severe malaria (SM) phenotypes. In a large study involving > 10,000 individuals and encompassing 3 African populations, we found evidence to support the reported associations between the TNF -238 polymorphism and SM in The Gambia. However, no TNF/LTA polymorphisms were found to be associated with SM in cohorts in Kenya and Malawi. It has been suggested that the causal polymorphisms regulating the TNF and LTA responses may be located some distance from the genes. Therefore, more-detailed mapping of variants across TNF/LTA genes and their flanking regions in the Gambian and allied populations may need to be undertaken to find any causal polymorphisms.",
author = "Clark, {Taane G.} and Mahamadou Diakite and Sarah Auburn and Susana Campino and Fry, {Andrew E.} and Angela Green and Anna Richardson and Kerrin Small and Teo, {Yik Y.} and Jonathan Wilson and Muminatou Jallow and Fatou Sisay-Joof and Margaret Pinder and Griffiths, {Michael J.} and Norbert Peshu and Williams, {Thomas N.} and Kevin Marsh and Molyneux, {Malcolm E.} and Taylor, {Terrie E.} and Rockett, {Kirk A.} and Kwiatkowski, {Dominic P.}",
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Clark, TG, Diakite, M, Auburn, S, Campino, S, Fry, AE, Green, A, Richardson, A, Small, K, Teo, YY, Wilson, J, Jallow, M, Sisay-Joof, F, Pinder, M, Griffiths, MJ, Peshu, N, Williams, TN, Marsh, K, Molyneux, ME, Taylor, TE, Rockett, KA & Kwiatkowski, DP 2009, 'Tumor necrosis factor and lymphotoxin-α polymorphisms and severe malaria in African populations', Journal of Infectious Diseases, vol. 199, no. 4, pp. 569-575. https://doi.org/10.1086/596320

Tumor necrosis factor and lymphotoxin-α polymorphisms and severe malaria in African populations. / Clark, Taane G.; Diakite, Mahamadou; Auburn, Sarah; Campino, Susana; Fry, Andrew E.; Green, Angela; Richardson, Anna; Small, Kerrin; Teo, Yik Y.; Wilson, Jonathan; Jallow, Muminatou; Sisay-Joof, Fatou; Pinder, Margaret; Griffiths, Michael J.; Peshu, Norbert; Williams, Thomas N.; Marsh, Kevin; Molyneux, Malcolm E.; Taylor, Terrie E.; Rockett, Kirk A.; Kwiatkowski, Dominic P.

In: Journal of Infectious Diseases, Vol. 199, No. 4, 2009, p. 569-575.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Tumor necrosis factor and lymphotoxin-α polymorphisms and severe malaria in African populations

AU - Clark, Taane G.

AU - Diakite, Mahamadou

AU - Auburn, Sarah

AU - Campino, Susana

AU - Fry, Andrew E.

AU - Green, Angela

AU - Richardson, Anna

AU - Small, Kerrin

AU - Teo, Yik Y.

AU - Wilson, Jonathan

AU - Jallow, Muminatou

AU - Sisay-Joof, Fatou

AU - Pinder, Margaret

AU - Griffiths, Michael J.

AU - Peshu, Norbert

AU - Williams, Thomas N.

AU - Marsh, Kevin

AU - Molyneux, Malcolm E.

AU - Taylor, Terrie E.

AU - Rockett, Kirk A.

AU - Kwiatkowski, Dominic P.

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