Using genomics to understand meticillin- and vancomycin-resistant Staphylococcus aureus infections

Stefano G. Giulieri; Steven Y.C. Tong; Deborah A. Williamson

doi:10.1099/mgen.0.000324

Using genomics to understand meticillin- and vancomycin-resistant Staphylococcus aureus infections

Stefano G. Giulieri, Steven Y.C. Tong, Deborah A. Williamson

Global and Tropical Health

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Abstract

Resistance to meticillin and vancomycin in Staphylococcus aureus significantly complicates the management of severe infections like bacteraemia, endocarditis or osteomyelitis. Here, we review the molecular mechanisms and genomic epidemiology of resistance to these agents, with a focus on how genomics has provided insights into the emergence and evolution of major meticillin-resistant S. aureus clones. We also provide insights on the use of bacterial whole-genome sequencing to inform management of S. aureus infections and for control of transmission at the hospital and in the community.

Original language	English
Pages (from-to)	1-15
Number of pages	15
Journal	Microbial Genomics
Volume	6
Issue number	1
DOIs	https://doi.org/10.1099/mgen.0.000324
Publication status	Published - 1 Jan 2020

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26933114-oaFinal published version, 876 KBLicence: CC BY

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Using genomics to understand meticillin- and vancomycin-resistant Staphylococcus aureus infections

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