Using genomics to understand meticillin- and vancomycin-resistant Staphylococcus aureus infections

Stefano G. Giulieri, Steven Y.C. Tong, Deborah A. Williamson

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    Abstract

    Resistance to meticillin and vancomycin in Staphylococcus aureus significantly complicates the management of severe infections like bacteraemia, endocarditis or osteomyelitis. Here, we review the molecular mechanisms and genomic epidemiology of resistance to these agents, with a focus on how genomics has provided insights into the emergence and evolution of major meticillin-resistant S. aureus clones. We also provide insights on the use of bacterial whole-genome sequencing to inform management of S. aureus infections and for control of transmission at the hospital and in the community.

    Original languageEnglish
    Pages (from-to)1-15
    Number of pages15
    JournalMicrobial Genomics
    Volume6
    Issue number1
    DOIs
    Publication statusPublished - 1 Jan 2020

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