Vancomycin Exposure and Acute Kidney Injury Outcome: A Snapshot from the CAMERA2 Study

Jiajun Liu; Steven Y.C. Tong; Joshua S. Davis; Nathaniel J. Rhodes; Marc H. Scheetz

doi:10.1093/ofid/ofaa538

Vancomycin Exposure and Acute Kidney Injury Outcome: A Snapshot from the CAMERA2 Study

Jiajun Liu, Steven Y.C. Tong, Joshua S. Davis, Nathaniel J. Rhodes, Marc H. Scheetz

Menzies School of Health Research

Research output: Contribution to journal › Article › peer-review

Abstract

Among patients with methicillin-resistant Staphylococcus aureus (MRSA) bacteremia from a prospective randomized clinical trial, acute kidney injury (AKI) rates increased with increasing vancomycin exposure, even within the therapeutic range. AKI was independently more common for the (flu)cloxacillin group. Day 2 vancomycin AUC ≥470 mg·h/L was significantly associated with AKI, independent of (flu)cloxacillin receipt.

Original language	English
Article number	ofaa538
Pages (from-to)	1-5
Number of pages	5
Journal	Open Forum Infectious Diseases
Volume	7
Issue number	12
Early online date	Nov 2020
DOIs	https://doi.org/10.1093/ofid/ofaa538
Publication status	Published - Dec 2020

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ofaa538Final published version, 537 KBLicence: Other

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title = "Vancomycin Exposure and Acute Kidney Injury Outcome: A Snapshot from the CAMERA2 Study",

abstract = "Among patients with methicillin-resistant Staphylococcus aureus (MRSA) bacteremia from a prospective randomized clinical trial, acute kidney injury (AKI) rates increased with increasing vancomycin exposure, even within the therapeutic range. AKI was independently more common for the (flu)cloxacillin group. Day 2 vancomycin AUC ≥470 mg·h/L was significantly associated with AKI, independent of (flu)cloxacillin receipt. ",

keywords = "acute kidney injury, AUC, combination therapy, MRSA bacteremia, nephrotoxicity, pharmacokinetics, toxicodynamics, vancomycin, β-lactam",

author = "Jiajun Liu and Tong, {Steven Y.C.} and Davis, {Joshua S.} and Rhodes, {Nathaniel J.} and Scheetz, {Marc H.}",

note = "Publisher Copyright: {\textcopyright} 2020 The Author(s). Published by Oxford University Press on behalf of Infectious Diseases Society of America. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",

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AU - Rhodes, Nathaniel J.

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AB - Among patients with methicillin-resistant Staphylococcus aureus (MRSA) bacteremia from a prospective randomized clinical trial, acute kidney injury (AKI) rates increased with increasing vancomycin exposure, even within the therapeutic range. AKI was independently more common for the (flu)cloxacillin group. Day 2 vancomycin AUC ≥470 mg·h/L was significantly associated with AKI, independent of (flu)cloxacillin receipt.

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KW - AUC

KW - combination therapy

KW - MRSA bacteremia

KW - nephrotoxicity

KW - pharmacokinetics

KW - toxicodynamics

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KW - β-lactam

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Vancomycin Exposure and Acute Kidney Injury Outcome: A Snapshot from the CAMERA2 Study

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